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1-37 of 37
Keywords: alternative splicing
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Articles
The discovery, function, and regulation of epithelial splicing regulatory proteins (ESRP) 1 and 2
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1097–1109.
Published: 14 June 2023
...Jessica M. Derham; Auinash Kalsotra Alternative splicing is a broad and evolutionarily conserved mechanism to diversify gene expression and functionality. The process relies on RNA binding proteins (RBPs) to recognize and bind target sequences in pre-mRNAs, which allows for the inclusion...
Articles
Differential functions of the KRAS splice variants
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1191–1199.
Published: 24 May 2023
... in human cancer more frequently than any other oncogene. The KRAS pre-mRNA is alternatively spliced to generate two transcripts, KRAS4A and KRAS4B , that encode distinct proto-oncoproteins that differ almost exclusively in their C-terminal hypervariable regions (HVRs) that controls subcellular trafficking...
Articles
The long and short of EJC-independent nonsense-mediated RNA decay
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1121–1129.
Published: 05 May 2023
... sarcoma virus TCV turnip crinkle virus uORFs upstream ORFs alternative splicing exon-junction complexes nonsense-mediated decay RNA decay translation References 1 Brogna , S. , McLeod , T. and Petric , M. (2016) The meaning of NMD: translate...
Articles
The biological functions of nonsense-mediated mRNA decay in plants: RNA quality control and beyond
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 31–39.
Published: 25 January 2023
... ( [email protected] ) or Vivek K. Raxwal ( [email protected] ) 14 11 2022 11 1 2023 13 1 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 alternative splicing Arabidopsis thaliana nonsense-mediated decay...
Articles
Control of HIV-1 gene expression by SR proteins
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (5): 1417–1425.
Published: 19 October 2016
..., and translation. Due to their importance in regulating HIV-1 gene expression, SR proteins and their regulatory factors are potential antiviral drug targets. HIV-1 relies on alternative splicing and intron retention to express its nine genes using at least four splice donors (SDs) and eight splice acceptors (SAs...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (5): 1185–1200.
Published: 19 October 2016
... will then discuss molecular principles by which regulatory mechanisms, such as alternative splicing and asymmetric localization of transcripts that encode disordered regions, can increase the functional versatility of proteins. Finally, I will discuss how disordered regions contribute to human disease...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1079–1085.
Published: 15 August 2016
... being a ‘splicing noise’, co-expression is often established through co-ordinated activity of specific cis -elements and trans -acting factors. Further work in this area may uncover new biological functions of alternative splicing (AS) and generate important insights into mechanisms allowing different...
Articles
STARs in the CNS
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1066–1072.
Published: 15 August 2016
... targets in the CNS (central nervous system). 1 To whom correspondence should be addressed (email [email protected] ). 31 3 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 alternative splicing CNS (central nervous...
Articles
Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins
Available to PurchaseMiguel B. Coelho, David B. Ascher, Clare Gooding, Emma Lang, Hannah Maude, David Turner, Miriam Llorian, Douglas E.V. Pires, Jan Attig, Christopher W.J. Smith
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1058–1065.
Published: 15 August 2016
... © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 alternative splicing heterogeneous nuclear ribonucleoprotein (hnRNP) Matrin3 polypyrimidine tract binding protein PTB RNA Polypyrimidine tract binding protein 1 (PTBP1) acts widely...
Articles
Regulation of the expression and activity of Unr in mammalian cells
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (6): 1241–1246.
Published: 27 November 2015
... of the downstream N-ras gene, is tissue and developmental stage-dependent and is repressed by c-Myc and Max (Myc associated factor X). Alternative splicing gives rise to six transcript variants, which include three different 5′-UTRs. The transcripts are further diversified by the use of three alternative...
Articles
RBFOX2 protein domains and cellular activities
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1180–1183.
Published: 11 August 2014
... alternative splicing regulation and steroid receptors transcriptional activity. Its ability to regulate specific splicing profiles depending on context has been related to different expression levels of the RBFOX2 protein itself and that of other splicing regulatory proteins involved in the shared modulation...
Articles
Structural investigations of the RNA-binding properties of STAR proteins
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1141–1146.
Published: 11 August 2014
...Mikael Feracci; Jaelle Foot; Cyril Dominguez STAR (signal transduction and activation of RNA) proteins are a family of RNA-binding proteins that regulate post-transcriptional gene regulation events at various levels, such as pre-mRNA alternative splicing, RNA export, translation and stability. Most...
Articles
Regulation of gene expression through production of unstable mRNA isoforms
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1196–1205.
Published: 11 August 2014
...Christopher R. Sibley Alternative splicing is universally accredited for expanding the information encoded within the transcriptome. In recent years, several tightly regulated alternative splicing events have been reported which do not lead to generation of protein products, but lead to unstable...
Articles
Regulation of ELAV/Hu RNA-binding proteins by phosphorylation
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1147–1151.
Published: 11 August 2014
... contributed equally to this work. 2 To whom correspondence should be addressed (email [email protected] ). 15 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 alternative splicing ELAV/Hu family proteins nucleocytoplasmic shuttling phosphorylation...
Articles
Tra2 protein biology and mechanisms of splicing control
Available to PurchaseAndrew Best, Caroline Dalgliesh, Mahsa Kheirollahi-Kouhestani, Marina Danilenko, Ingrid Ehrmann, Alison Tyson-Capper, David J. Elliott
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1152–1158.
Published: 11 August 2014
... alternative splicing Drosophila gene expression RNA recognition motif RS domain Tra2 Figure 3 Model exons regulated by Tra2 ( A ) Splicing activation of the human HIPK3T exon is activated by 4 Tra2-responsive ESEs. ( B ) Activation of the female-specific 3′ splice site in the fruitfly...
Articles
The intriguing case of motor neuron disease: ALS and SMA come closer
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1593–1597.
Published: 20 November 2013
... of the lower motor neurons [ 10 ]. ALS amyotrophic lateral sclerosis AS alternative splicing CNS central nervous system FUS fused in sarcoma hnRNP heterogeneous nuclear ribonucleoprotein LSm like-Sm MND motor neuron disease(s) mRNP messenger...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1532–1535.
Published: 20 November 2013
.../ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. alternative splicing Alu element disease evolution intron transposable element The non-coding sequence (i.e. the sequence that does not code for proteins...
Articles
BRCA1 exon 11 alternative splicing, multiple functions and the association with cancer
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 768–772.
Published: 20 July 2012
...Claudia Tammaro; Michela Raponi; David I. Wilson; Diana Baralle BRCA1 (breast cancer early-onset 1) alternative splicing levels are regulated in a cell-cycle- and cell-type-specific manner, with splice variants being present in different proportions in tumour cell lines as well as in normal mammary...
Articles
Human papillomavirus gene expression is controlled by host cell splicing factors
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 773–777.
Published: 20 July 2012
... expression to ensure efficient virus replication. For example, the viral transcription factor E2 can directly up-regulate, in an epithelial differentiation-dependent manner, cellular SRSFs [SR (serine/arginine-rich) splicing factors] that control constitutive and alternative splicing. Changes in alternative...
Articles
Mechanisms of Drosophila Dscam mutually exclusive splicing regulation
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 804–809.
Published: 20 July 2012
...Yash Hemani; Matthias Soller Alternative splicing of pre-mRNA is a major mechanism to increase protein diversity in higher eukaryotes. Dscam , the Drosophila homologue of human DSCAM (Down's syndrome cell adhesion molecule), generates up to 38016 isoforms through mutually exclusive splicing in four...
Articles
Role of splice variants in the metastatic progression of prostate cancer
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 870–874.
Published: 20 July 2012
...Rachel M. Hagen; Michael R. Ladomery AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice variants of cancer-associated genes have...
Articles
Tau alternative splicing in familial and sporadic tauopathies
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 677–680.
Published: 20 July 2012
...Michael Niblock; Jean-Marc Gallo Six tau isoforms differing in their affinity for microtubules are produced by alternative splicing from the MAPT (microtubule-associated protein tau) gene in adult human brain. Several MAPT mutations causing the familial tauopathy, FTDP-17 (frontotemporal dementia...
Articles
Defining the roles and interactions of PTB
Available to PurchasePanagiota Kafasla, Ian Mickleburgh, Miriam Llorian, Miguel Coelho, Clare Gooding, Dmitry Cherny, Amar Joshi, Olga Kotik-Kogan, Stephen Curry, Ian C. Eperon, Richard J. Jackson, Christopher W.J. Smith
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 815–820.
Published: 20 July 2012
... with four RRM (RNA recognition motif) domains. PTB is involved in numerous post-transcriptional steps in gene expression in both the nucleus and cytoplasm, but has been best characterized as a regulatory repressor of some ASEs (alternative splicing events), and as an activator of translation driven by IRESs...
Articles
Cell autonomous and systemic factors in progeria development
Available to PurchaseFernando G. Osorio, Alejandro P. Ugalde, Guillermo Mariño, Xose S. Puente, José M.P. Freije, Carlos López-Otín
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1710–1714.
Published: 21 November 2011
... Society 2011 alternative splicing laminopathy microRNA (miRNA) progeria senescence tumour suppressor The nuclear envelope is a complex structure that surrounds and protects the genome, playing essential roles in its regulation, organization and maintenance [ 1 ]. The nuclear envelope...
Articles
Determinants of ELAV gene-specific regulation
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1122–1124.
Published: 26 July 2010
... ]. 1 To whom correspondence should be addressed (email [email protected] ). 23 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 alternative polyadenylation alternative splicing embryonic lethal abnormal visual system (ELAV) nervous system development...
Articles
Regulation of plant gene expression by alternative splicing
Available to PurchaseCraig G. Simpson, Sujatha Manthri, Katarzyna Dorota Raczynska, Maria Kalyna, Dominika Lewandowska, Branislav Kusenda, Monika Maronova, Zofia Szweykowska-Kulinska, Artur Jarmolowski, Andrea Barta, John W.S. Brown
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 667–671.
Published: 22 March 2010
...Craig G. Simpson; Sujatha Manthri; Katarzyna Dorota Raczynska; Maria Kalyna; Dominika Lewandowska; Branislav Kusenda; Monika Maronova; Zofia Szweykowska-Kulinska; Artur Jarmolowski; Andrea Barta; John W.S. Brown AS (alternative splicing) is a post-transcriptional process which regulates gene...
Articles
Splicing, cis genetic variation and disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1311–1315.
Published: 19 November 2009
...Cathy J. Jensen; Brian J. Oldfield; Justin P. Rubio Splicing is a post-transcriptional modification of RNA during which introns are removed and exons are joined. Most of the mammalian genes undergo constitutive and alternative splicing events. In addition to the strong signals of the splice sites...
Articles
High-throughput sequencing methods to study neuronal RNA–protein interactions
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1278–1280.
Published: 19 November 2009
... of ribosomes or other large RNPs, it might become possible to draw RNA maps that guide the activity of RBPs in many different aspects of RNA processing and regulation. © The Authors Journal compilation © 2009 Biochemical Society 2009 alternative splicing cross-linking and immunoprecipitation...
Articles
Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (4): 641–647.
Published: 22 July 2008
... compilation © 2008 Biochemical Society 2008 alternative splicing internal ribosome entry site (IRES) IRES trans -acting factor (ITAF) polypyrimidine-tract-binding protein (PTB) RNA-binding protein RNA recognition motif (RRM) PTB (polypyrimidine-tract-binding protein), also referred...
Articles
Recognition of nonsense mRNA: towards a unified model
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 497–501.
Published: 21 May 2008
... phosphorylation would be shortened and the balance between PABP action (NMD suppression) and UPF1 action (NMD promotion) would tilt towards NMD. 1 email [email protected] 7 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 alternative splicing...
Articles
Regulation of the ELAV target ewg : insights from an evolutionary perspective
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 502–504.
Published: 21 May 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 alternative polyadenylation alternative splicing embryonic lethal abnormal visual system (ELAV) erect wing gene ( ewg gene) evolution nervous system development ELAV (embryonic lethal abnormal visual system) from...
Articles
Alternative splicing in plants
Available to PurchaseCraig G. Simpson, Dominika Lewandowska, John Fuller, Monika Maronova, Maria Kalyna, Diane Davidson, Jim McNicol, Dorota Raczynska, Artur Jarmolowski, Andrea Barta, John W.S. Brown
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 508–510.
Published: 21 May 2008
...Craig G. Simpson; Dominika Lewandowska; John Fuller; Monika Maronova; Maria Kalyna; Diane Davidson; Jim McNicol; Dorota Raczynska; Artur Jarmolowski; Andrea Barta; John W.S. Brown The impact of AS (alternative splicing) is well-recognized in animal systems as a key regulator of gene expression...
Articles
The use of Affymetrix GeneChips as a tool for studying alternative forms of RNA
Available to PurchaseAndrew P. Harrison, Joanna Rowsell, Renata da Silva Camargo, William B. Langdon, Maria Stalteri, Graham J.G. Upton, Jose M. Arteaga-Salas
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 511–513.
Published: 21 May 2008
... affect detection of gene expression by Affymetrix GeneChip® arrays Appl. Bioinformatics 2006 5 249 253 Affymetrix GeneChip alternative polyadenylation alternative splicing microarray post-transcriptional processing RNA Microarrays are pervasive technology, widely used...
Articles
TRPM3, a biophysical enigma?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 89–90.
Published: 22 January 2007
... by intracellular Mg 2+ ions. Besides these rather common features, in which TRPM3 channels resemble the closely related channels TRPM6 and TRPM7, TRPM3 channels have several unique characteristics. The TRPM3 gene encodes a plethora of different proteins owing to alternative splicing and alternative exon usage. One...
Articles
Multiple roles of arginine/serine-rich splicing factors in RNA processing
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (3): 443–446.
Published: 01 June 2005
... of post-transcriptional gene expression. 1 To whom correspondence should be addressed (email [email protected] ). 13 1 2005 © 2005 The Biochemical Society 2005 alternative splicing pre-mRNA splicing RNA processing RS domain small nuclear ribonucleoprotein (RNP...
Articles
Regulation of alternative splicing by PTB and associated factors
Available to PurchaseR. Spellman, A. Rideau, A. Matlin, C. Gooding, F. Robinson, N. McGlincy, S.N. Grellscheid, J. Southby, M. Wollerton, C.W.J. Smith
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (3): 457–460.
Published: 01 June 2005
...R. Spellman; A. Rideau; A. Matlin; C. Gooding; F. Robinson; N. McGlincy; S.N. Grellscheid; J. Southby; M. Wollerton; C.W.J. Smith PTB (polypyrimidine tract-binding protein) is a repressive regulator of alternative splicing. We have investigated the role of PTB in three model alternative splicing...
Articles
UNC-52/perlecan isoform diversity and function in Caenorhabditis elegans
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (2): 171–176.
Published: 01 May 2001
... receptors, laminin and neural cell-adhesion molecules. Three major classes of UNC-52/perlecan isoforms are produced through alternative splicing, and these distinct proteins exhibit complex spatial and temporal expression patterns throughout development. The unc-52 gene plays an essential role...
