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Keywords: alternative splicing
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Articles
Biochem Soc Trans (2023) 51 (3): 1097–1109.
Published: 14 June 2023
...Jessica M. Derham; Auinash Kalsotra Alternative splicing is a broad and evolutionarily conserved mechanism to diversify gene expression and functionality. The process relies on RNA binding proteins (RBPs) to recognize and bind target sequences in pre-mRNAs, which allows for the inclusion...
Articles
Biochem Soc Trans (2023) 51 (3): 1191–1199.
Published: 24 May 2023
... in human cancer more frequently than any other oncogene. The KRAS pre-mRNA is alternatively spliced to generate two transcripts, KRAS4A and KRAS4B , that encode distinct proto-oncoproteins that differ almost exclusively in their C-terminal hypervariable regions (HVRs) that controls subcellular trafficking...
Articles
Biochem Soc Trans (2023) 51 (3): 1121–1129.
Published: 05 May 2023
... Society 2023 alternative splicing exon-junction complexes nonsense-mediated decay RNA decay translation There are two variations of the NMD pathway that recognize and degrade PTC-containing transcripts: (1) EJC-dependent NMD, which relies on the retention of EJCs near splice sites...
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Biochem Soc Trans (2023) 51 (1): 31–39.
Published: 25 January 2023
... ( karel.riha@ceitec.muni.cz ) or Vivek K. Raxwal ( vivek.raxwal@ceitec.muni.cz ) 14 11 2022 11 1 2023 13 1 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 alternative splicing Arabidopsis thaliana nonsense-mediated decay...
Articles
Biochem Soc Trans (2016) 44 (5): 1185–1200.
Published: 19 October 2016
... will then discuss molecular principles by which regulatory mechanisms, such as alternative splicing and asymmetric localization of transcripts that encode disordered regions, can increase the functional versatility of proteins. Finally, I will discuss how disordered regions contribute to human disease...
Articles
Biochem Soc Trans (2016) 44 (5): 1417–1425.
Published: 19 October 2016
...); published by Portland Press Limited on behalf of the Biochemical Society 2016 alternative splicing eukaryotic gene expression HIV RNA metabolism SR proteins Human immunodeficiency virus type 1 (HIV-1) is a member of the retrovirus family of positive-strand RNA viruses that reverse...
Articles
Articles
Biochem Soc Trans (2016) 44 (4): 1066–1072.
Published: 15 August 2016
... targets in the CNS (central nervous system). 1 To whom correspondence should be addressed (email ingrid.ehrmann@ncl.ac.uk ). 31 3 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 alternative splicing CNS (central nervous...
Articles
Biochem Soc Trans (2016) 44 (4): 1079–1085.
Published: 15 August 2016
... being a ‘splicing noise’, co-expression is often established through co-ordinated activity of specific cis -elements and trans -acting factors. Further work in this area may uncover new biological functions of alternative splicing (AS) and generate important insights into mechanisms allowing different...
Articles
Biochem Soc Trans (2015) 43 (6): 1241–1246.
Published: 27 November 2015
... of the downstream N-ras gene, is tissue and developmental stage-dependent and is repressed by c-Myc and Max (Myc associated factor X). Alternative splicing gives rise to six transcript variants, which include three different 5′-UTRs. The transcripts are further diversified by the use of three alternative...
Articles
Biochem Soc Trans (2014) 42 (4): 1141–1146.
Published: 11 August 2014
...Mikael Feracci; Jaelle Foot; Cyril Dominguez STAR (signal transduction and activation of RNA) proteins are a family of RNA-binding proteins that regulate post-transcriptional gene regulation events at various levels, such as pre-mRNA alternative splicing, RNA export, translation and stability. Most...
Articles
Biochem Soc Trans (2014) 42 (4): 1196–1205.
Published: 11 August 2014
...Christopher R. Sibley Alternative splicing is universally accredited for expanding the information encoded within the transcriptome. In recent years, several tightly regulated alternative splicing events have been reported which do not lead to generation of protein products, but lead to unstable...
Articles
Biochem Soc Trans (2014) 42 (4): 1147–1151.
Published: 11 August 2014
... Society 2014 alternative splicing ELAV/Hu family proteins nucleocytoplasmic shuttling phosphorylation RNA-binding protein ELAV (embryonic lethal/abnormal visual system)/Hu family proteins are important regulators of neuronal RNA processing and are implicated in alternative splicing...
Articles
Biochem Soc Trans (2014) 42 (4): 1152–1158.
Published: 11 August 2014
... alternative splicing Drosophila gene expression RNA recognition motif RS domain Tra2 Tra2 proteins are nuclear RNA-binding proteins involved in splicing regulation ( Figure 1 A). Tra2 proteins are conserved across the animal kingdom. Invertebrates have a single Tra2 protein copy (of which...
Articles
Biochem Soc Trans (2014) 42 (4): 1180–1183.
Published: 11 August 2014
... alternative splicing regulation and steroid receptors transcriptional activity. Its ability to regulate specific splicing profiles depending on context has been related to different expression levels of the RBFOX2 protein itself and that of other splicing regulatory proteins involved in the shared modulation...
Articles
Biochem Soc Trans (2013) 41 (6): 1593–1597.
Published: 20 November 2013
... are part of localized mRNPs in all neuronal dendrites and in some axons, most notably of the spinal cord motor neurons [ 18 ]. ALS amyotrophic lateral sclerosis AS alternative splicing CNS central nervous system FUS fused in sarcoma hnRNP heterogeneous nuclear...
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Biochem Soc Trans (2013) 41 (6): 1532–1535.
Published: 20 November 2013
..., distribution and reproduction in any medium, provided the original work is properly cited. alternative splicing Alu element disease evolution intron transposable element The non-coding sequence (i.e. the sequence that does not code for proteins) represents 98% of our genome. The primary...
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Articles
Biochem Soc Trans (2012) 40 (4): 773–777.
Published: 20 July 2012
... expression to ensure efficient virus replication. For example, the viral transcription factor E2 can directly up-regulate, in an epithelial differentiation-dependent manner, cellular SRSFs [SR (serine/arginine-rich) splicing factors] that control constitutive and alternative splicing. Changes in alternative...
Articles
Biochem Soc Trans (2012) 40 (4): 804–809.
Published: 20 July 2012
...Yash Hemani; Matthias Soller Alternative splicing of pre-mRNA is a major mechanism to increase protein diversity in higher eukaryotes. Dscam , the Drosophila homologue of human DSCAM (Down's syndrome cell adhesion molecule), generates up to 38016 isoforms through mutually exclusive splicing in four...
Articles
Biochem Soc Trans (2012) 40 (4): 870–874.
Published: 20 July 2012
...Rachel M. Hagen; Michael R. Ladomery AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice variants of cancer-associated genes have...
Articles
Biochem Soc Trans (2012) 40 (4): 677–680.
Published: 20 July 2012
...Michael Niblock; Jean-Marc Gallo Six tau isoforms differing in their affinity for microtubules are produced by alternative splicing from the MAPT (microtubule-associated protein tau) gene in adult human brain. Several MAPT mutations causing the familial tauopathy, FTDP-17 (frontotemporal dementia...
Articles
Biochem Soc Trans (2012) 40 (4): 815–820.
Published: 20 July 2012
... with four RRM (RNA recognition motif) domains. PTB is involved in numerous post-transcriptional steps in gene expression in both the nucleus and cytoplasm, but has been best characterized as a regulatory repressor of some ASEs (alternative splicing events), and as an activator of translation driven by IRESs...
Articles
Biochem Soc Trans (2011) 39 (6): 1710–1714.
Published: 21 November 2011
... 2011 alternative splicing laminopathy microRNA (miRNA) progeria senescence tumour suppressor The nuclear envelope is a complex structure that surrounds and protects the genome, playing essential roles in its regulation, organization and maintenance [ 1 ]. The nuclear envelope...
Articles
Biochem Soc Trans (2010) 38 (4): 1122–1124.
Published: 26 July 2010
... © 2010 Biochemical Society 2010 alternative polyadenylation alternative splicing embryonic lethal abnormal visual system (ELAV) nervous system development RNA-binding proteins comprise a major class in the proteome of eukaryotes. Important functions for RNA-binding proteins...
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Biochem Soc Trans (2009) 37 (6): 1311–1315.
Published: 19 November 2009
...Cathy J. Jensen; Brian J. Oldfield; Justin P. Rubio Splicing is a post-transcriptional modification of RNA during which introns are removed and exons are joined. Most of the mammalian genes undergo constitutive and alternative splicing events. In addition to the strong signals of the splice sites...
Articles
Biochem Soc Trans (2009) 37 (6): 1278–1280.
Published: 19 November 2009
..., that applications of new biochemical techniques followed by high-throughput sequencing will continue to provide important insights into the mechanisms of neuronal post-transcriptional regulation. alternative splicing cross-linking and immunoprecipitation (CLIP) microRNA (miRNA) ribosome profiling synaptic...
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Biochem Soc Trans (2008) 36 (4): 641–647.
Published: 22 July 2008
... regulates these disparate processes. 1 To whom correspondence should be addressed (email anne.willis@nottingham.ac.uk ). 31 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 alternative splicing internal ribosome entry site (IRES) IRES trans -acting...
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Biochem Soc Trans (2008) 36 (3): 497–501.
Published: 21 May 2008
...-promoting protein complex including the conserved NMD factors UPF (up-frameshift) 1–3. 1 email oliver.muehlemann@izb.unibe.ch 7 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 alternative splicing exon junction complex gene expression nonsense-mediated...
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Biochem Soc Trans (2008) 36 (3): 502–504.
Published: 21 May 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 alternative polyadenylation alternative splicing embryonic lethal abnormal visual system (ELAV) erect wing gene ( ewg gene) evolution nervous system development ELAV (embryonic lethal abnormal visual system) from Drosophila...
Articles
Biochem Soc Trans (2008) 36 (3): 508–510.
Published: 21 May 2008
...Craig G. Simpson; Dominika Lewandowska; John Fuller; Monika Maronova; Maria Kalyna; Diane Davidson; Jim McNicol; Dorota Raczynska; Artur Jarmolowski; Andrea Barta; John W.S. Brown The impact of AS (alternative splicing) is well-recognized in animal systems as a key regulator of gene expression...
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Biochem Soc Trans (2008) 36 (3): 511–513.
Published: 21 May 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 Affymetrix GeneChip alternative polyadenylation alternative splicing microarray post-transcriptional processing RNA Microarrays are pervasive technology, widely used in the life sciences to measure genome-wide transcriptional...
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Biochem Soc Trans (2007) 35 (1): 89–90.
Published: 22 January 2007
... by intracellular Mg 2+ ions. Besides these rather common features, in which TRPM3 channels resemble the closely related channels TRPM6 and TRPM7, TRPM3 channels have several unique characteristics. The TRPM3 gene encodes a plethora of different proteins owing to alternative splicing and alternative exon usage. One...
Articles
Biochem Soc Trans (2005) 33 (3): 457–460.
Published: 01 June 2005
...R. Spellman; A. Rideau; A. Matlin; C. Gooding; F. Robinson; N. McGlincy; S.N. Grellscheid; J. Southby; M. Wollerton; C.W.J. Smith PTB (polypyrimidine tract-binding protein) is a repressive regulator of alternative splicing. We have investigated the role of PTB in three model alternative splicing...
Articles
Biochem Soc Trans (2005) 33 (3): 443–446.
Published: 01 June 2005
... of post-transcriptional gene expression. 1 To whom correspondence should be addressed (email Javier.Caceres@hgu.mrc.ac.uk ). 13 1 2005 © 2005 The Biochemical Society 2005 alternative splicing pre-mRNA splicing RNA processing RS domain small nuclear ribonucleoprotein (RNP...
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Biochem Soc Trans (2001) 29 (2): 171–176.
Published: 01 May 2001
... receptors, laminin and neural cell-adhesion molecules. Three major classes of UNC-52/perlecan isoforms are produced through alternative splicing, and these distinct proteins exhibit complex spatial and temporal expression patterns throughout development. The unc-52 gene plays an essential role...