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Keywords: alternative splicing
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (5): 1417–1425.
Published: 19 October 2016
... elongation by several mechanisms, including phosphorylating the C-terminal domain of RNA polymerase II. alternative splicing eukaryotic gene expression HIV RNA metabolism SR proteins © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 6...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (5): 1185–1200.
Published: 19 October 2016
... will then discuss molecular principles by which regulatory mechanisms, such as alternative splicing and asymmetric localization of transcripts that encode disordered regions, can increase the functional versatility of proteins. Finally, I will discuss how disordered regions contribute to human disease...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1066–1072.
Published: 15 August 2016
... targets in the CNS (central nervous system). 1 To whom correspondence should be addressed (email ingrid.ehrmann@ncl.ac.uk ). 31 3 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 alternative splicing CNS (central nervous...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1079–1085.
Published: 15 August 2016
... being a ‘splicing noise’, co-expression is often established through co-ordinated activity of specific cis -elements and trans -acting factors. Further work in this area may uncover new biological functions of alternative splicing (AS) and generate important insights into mechanisms allowing different...
Articles
Miguel B. Coelho, David B. Ascher, Clare Gooding, Emma Lang, Hannah Maude, David Turner, Miriam Llorian, Douglas E.V. Pires, Jan Attig, Christopher W.J. Smith
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1058–1065.
Published: 15 August 2016
... © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 alternative splicing heterogeneous nuclear ribonucleoprotein (hnRNP) Matrin3 polypyrimidine tract binding protein PTB RNA Polypyrimidine tract binding protein 1 (PTBP1) acts widely...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (6): 1241–1246.
Published: 27 November 2015
... of the downstream N-ras gene, is tissue and developmental stage-dependent and is repressed by c-Myc and Max (Myc associated factor X). Alternative splicing gives rise to six transcript variants, which include three different 5′-UTRs. The transcripts are further diversified by the use of three alternative...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1141–1146.
Published: 11 August 2014
...Mikael Feracci; Jaelle Foot; Cyril Dominguez STAR (signal transduction and activation of RNA) proteins are a family of RNA-binding proteins that regulate post-transcriptional gene regulation events at various levels, such as pre-mRNA alternative splicing, RNA export, translation and stability. Most...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1196–1205.
Published: 11 August 2014
...Christopher R. Sibley Alternative splicing is universally accredited for expanding the information encoded within the transcriptome. In recent years, several tightly regulated alternative splicing events have been reported which do not lead to generation of protein products, but lead to unstable...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1147–1151.
Published: 11 August 2014
... affects cellular localization of ELAV/Hu proteins and their binding to RNA. 15 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 alternative splicing ELAV/Hu family proteins nucleocytoplasmic shuttling phosphorylation RNA-binding protein ELAV (embryonic...
Articles
Andrew Best, Caroline Dalgliesh, Mahsa Kheirollahi-Kouhestani, Marina Danilenko, Ingrid Ehrmann, Alison Tyson-Capper, David J. Elliott
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1152–1158.
Published: 11 August 2014
... alternative splicing Drosophila gene expression RNA recognition motif RS domain Tra2 Cassette exons are the most frequent form of alternative splicing in human and mouse cells. A key feature of several Tra2 protein-regulated exons are multiple individual Tra2-binding sites within the target RNA...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1180–1183.
Published: 11 August 2014
... alternative splicing regulation and steroid receptors transcriptional activity. Its ability to regulate specific splicing profiles depending on context has been related to different expression levels of the RBFOX2 protein itself and that of other splicing regulatory proteins involved in the shared modulation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1532–1535.
Published: 20 November 2013
... Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) ( http://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. alternative splicing Alu...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1593–1597.
Published: 20 November 2013
....it ). 12 7 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 alternative splicing amyotrophic lateral sclerosis (ALS) fused in sarcoma (FUS) motor neuron disease RNA metabolism spinal muscular atrophy (SMA) survival of motor neuron (SMN) ALS amyotrophic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 768–772.
Published: 20 July 2012
...Claudia Tammaro; Michela Raponi; David I. Wilson; Diana Baralle BRCA1 (breast cancer early-onset 1) alternative splicing levels are regulated in a cell-cycle- and cell-type-specific manner, with splice variants being present in different proportions in tumour cell lines as well as in normal mammary...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 773–777.
Published: 20 July 2012
... expression to ensure efficient virus replication. For example, the viral transcription factor E2 can directly up-regulate, in an epithelial differentiation-dependent manner, cellular SRSFs [SR (serine/arginine-rich) splicing factors] that control constitutive and alternative splicing. Changes in alternative...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 804–809.
Published: 20 July 2012
...Yash Hemani; Matthias Soller Alternative splicing of pre-mRNA is a major mechanism to increase protein diversity in higher eukaryotes. Dscam , the Drosophila homologue of human DSCAM (Down's syndrome cell adhesion molecule), generates up to 38016 isoforms through mutually exclusive splicing in four...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 870–874.
Published: 20 July 2012
...Rachel M. Hagen; Michael R. Ladomery AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice variants of cancer-associated genes have...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 677–680.
Published: 20 July 2012
...Michael Niblock; Jean-Marc Gallo Six tau isoforms differing in their affinity for microtubules are produced by alternative splicing from the MAPT (microtubule-associated protein tau) gene in adult human brain. Several MAPT mutations causing the familial tauopathy, FTDP-17 (frontotemporal dementia...
Articles
Panagiota Kafasla, Ian Mickleburgh, Miriam Llorian, Miguel Coelho, Clare Gooding, Dmitry Cherny, Amar Joshi, Olga Kotik-Kogan, Stephen Curry, Ian C. Eperon, Richard J. Jackson, Christopher W.J. Smith
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 815–820.
Published: 20 July 2012
... with four RRM (RNA recognition motif) domains. PTB is involved in numerous post-transcriptional steps in gene expression in both the nucleus and cytoplasm, but has been best characterized as a regulatory repressor of some ASEs (alternative splicing events), and as an activator of translation driven by IRESs...
Articles
Fernando G. Osorio, Alejandro P. Ugalde, Guillermo Mariño, Xose S. Puente, José M.P. Freije, Carlos López-Otín
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1710–1714.
Published: 21 November 2011
... envelope proteins and chromatin [ 4 ]. In humans, three genes named LMNA , LMNB1 and LMNB2 encode nuclear lamins. Whereas the two B-type lamins are encoded by two independent genes, LMNB1 and LMNB2 , the LMNA gene encodes lamin A and lamin C proteins by alternative splicing. Mutations in A-type...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1122–1124.
Published: 26 July 2010
... proteins comprise a major class in the proteome of eukaryotes. Important functions for RNA-binding proteins are indicated in the brain, since alternative splicing is particularly prominent in this organ [ 1 ]. A prominent family of prototype RNA-binding proteins expressed in neurons are comprised by ELAV...
Articles
Craig G. Simpson, Sujatha Manthri, Katarzyna Dorota Raczynska, Maria Kalyna, Dominika Lewandowska, Branislav Kusenda, Monika Maronova, Zofia Szweykowska-Kulinska, Artur Jarmolowski, Andrea Barta, John W.S. Brown
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 667–671.
Published: 22 March 2010
...Craig G. Simpson; Sujatha Manthri; Katarzyna Dorota Raczynska; Maria Kalyna; Dominika Lewandowska; Branislav Kusenda; Monika Maronova; Zofia Szweykowska-Kulinska; Artur Jarmolowski; Andrea Barta; John W.S. Brown AS (alternative splicing) is a post-transcriptional process which regulates gene...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1311–1315.
Published: 19 November 2009
...Cathy J. Jensen; Brian J. Oldfield; Justin P. Rubio Splicing is a post-transcriptional modification of RNA during which introns are removed and exons are joined. Most of the mammalian genes undergo constitutive and alternative splicing events. In addition to the strong signals of the splice sites...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1278–1280.
Published: 19 November 2009
...-lmb.cam.ac.uk alternative splicing cross-linking and immunoprecipitation (CLIP) microRNA (miRNA) ribosome profiling synaptic plasticity UV-cross-linking Diverse post-transcriptional mechanisms allow a cell to precisely control the proteins to be synthesized at different cellular locations...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (4): 641–647.
Published: 22 July 2008
... of β-tropomyosin exon 3 has been shown to be dependent on the recruitment of the co-repressor Raver1 by PTB [ 35 , 38 – 40 ]. There are three main isoforms of PTB that are the result of alternative splicing [ 18 , 19 ]. PTB1 is the shortest isoform consisting of 531 amino acids, while PTB2...
Articles
Craig G. Simpson, Dominika Lewandowska, John Fuller, Monika Maronova, Maria Kalyna, Diane Davidson, Jim McNicol, Dorota Raczynska, Artur Jarmolowski, Andrea Barta, John W.S. Brown
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 508–510.
Published: 21 May 2008
...Craig G. Simpson; Dominika Lewandowska; John Fuller; Monika Maronova; Maria Kalyna; Diane Davidson; Jim McNicol; Dorota Raczynska; Artur Jarmolowski; Andrea Barta; John W.S. Brown The impact of AS (alternative splicing) is well-recognized in animal systems as a key regulator of gene expression...
Articles
Andrew P. Harrison, Joanna Rowsell, Renata da Silva Camargo, William B. Langdon, Maria Stalteri, Graham J.G. Upton, Jose M. Arteaga-Salas
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 511–513.
Published: 21 May 2008
... polyadenylation alternative splicing microarray post-transcriptional processing RNA Microarrays are pervasive technology, widely used in the life sciences to measure genome-wide transcriptional output in many organisms, phenotypes and tissues. A high-density oligonucleotide microarray...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 497–501.
Published: 21 May 2008
...-promoting protein complex including the conserved NMD factors UPF (up-frameshift) 1–3. 1 email oliver.muehlemann@izb.unibe.ch 7 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 alternative splicing exon junction complex gene expression nonsense-mediated...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 502–504.
Published: 21 May 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 alternative polyadenylation alternative splicing embryonic lethal abnormal visual system (ELAV) erect wing gene ( ewg gene) evolution nervous system development ELAV (embryonic lethal abnormal visual system) from...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 89–90.
Published: 22 January 2007
... by intracellular Mg 2+ ions. Besides these rather common features, in which TRPM3 channels resemble the closely related channels TRPM6 and TRPM7, TRPM3 channels have several unique characteristics. The TRPM3 gene encodes a plethora of different proteins owing to alternative splicing and alternative exon usage. One...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (3): 443–446.
Published: 01 June 2005
... of post-transcriptional gene expression. 1 To whom correspondence should be addressed (email Javier.Caceres@hgu.mrc.ac.uk ). 13 1 2005 © 2005 The Biochemical Society 2005 alternative splicing pre-mRNA splicing RNA processing RS domain small nuclear ribonucleoprotein (RNP...
Articles
R. Spellman, A. Rideau, A. Matlin, C. Gooding, F. Robinson, N. McGlincy, S.N. Grellscheid, J. Southby, M. Wollerton, C.W.J. Smith
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (3): 457–460.
Published: 01 June 2005
...R. Spellman; A. Rideau; A. Matlin; C. Gooding; F. Robinson; N. McGlincy; S.N. Grellscheid; J. Southby; M. Wollerton; C.W.J. Smith PTB (polypyrimidine tract-binding protein) is a repressive regulator of alternative splicing. We have investigated the role of PTB in three model alternative splicing...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (2): 171–176.
Published: 01 May 2001
... receptors, laminin and neural cell-adhesion molecules. Three major classes of UNC-52/perlecan isoforms are produced through alternative splicing, and these distinct proteins exhibit complex spatial and temporal expression patterns throughout development. The unc-52 gene plays an essential role...
