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Keywords: amyloid
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Articles
Biochem Soc Trans (2021) 49 (2): 977–985.
Published: 30 April 2021
...Marcus Fändrich; Matthias Schmidt Systemic amyloidosis is defined as a protein misfolding disease in which the amyloid is not necessarily deposited within the same organ that produces the fibril precursor protein. There are different types of systemic amyloidosis, depending on the protein...
Articles
Biochem Soc Trans (2020) 48 (2): 379–397.
Published: 20 April 2020
... vice versa. Redox signalling has been shown to play roles in almost every step of protein aggregation and amyloid formation, from aggregation initiation to the rapid oligomerization of large amyloids, which tend to be less toxic than oligomeric prefibrillar aggregates. We explore the hypothesis that...
Articles
Biochem Soc Trans (2018) 46 (4): 829–842.
Published: 09 July 2018
... the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . amyloid mitochondria mitophagy neurodegeneration tau proteins α-synuclein The energetic requirements of neuronal excitability, synaptic activity and plasticity are extensive...
Articles
Biochem Soc Trans (2014) 42 (5): 1286–1290.
Published: 18 September 2014
...Plamena R. Angelova; Andrey Y. Abramov Alzheimer's disease (AD) is a neurodegenerative disease characterized by the aggregation of amyloid β-peptide (Aβ) into β-sheet-rich fibrils. Although plaques containing Aβ fibrils have been viewed as the conventional hallmark of AD, recent research implicates...
Articles
Biochem Soc Trans (2014) 42 (5): 1316–1320.
Published: 18 September 2014
... elusive, as they seem to adopt different functions dependent on disease progression and the extent of accompanying parenchymal inflammation. Astrocytes may contribute to the clearance of amyloid β-peptide (Aβ) and restrict the spread of inflammation in the brain. Conversely, they may contribute to...
Articles
Biochem Soc Trans (2013) 41 (6): 1509–1512.
Published: 20 November 2013
... Biochemical Society 2013 amyloid Gaucher disease glucocerebrosidase lysosome Parkinson’s disease α-synuclein GCase (glucocerebrosidase), a 497-residue lysosomal hydrolase, cleaves the β-glucosyl linkage of GlcCer (glucosylceramide) to glucose and ceramide [ 1 ]. To date, over 300 mutations...
Articles
Biochem Soc Trans (2012) 40 (5): 1032–1037.
Published: 19 September 2012
... be addressed to either of these authors (email nsdgroot@mrc-lmb.cam.ac.uk or madanm@mrc-lmb.cam.ac.uk ). 10 7 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 amyloid chaperone evolution protein aggregation During evolution, cells have been...
Articles
Biochem Soc Trans (2012) 40 (5): 950–954.
Published: 19 September 2012
...-berlin.de ). 11 4 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 amyloid in-cell nuclear magnetic resonance (in-cell NMR) intrinsically disordered protein (IDP) α-synuclein tetramer α-Synuclein is expressed abundantly in brain dopaminergic neurons and...
Includes: Supplementary data
Articles
Biochem Soc Trans (2012) 40 (4): 721–727.
Published: 20 July 2012
... fibrils of the Aβ (amyloid β-peptide) and tau protein accumulate in specific brain regions. This is associated with the progressive destruction of synaptic circuits controlling memory and higher mental function. The primary signalling mechanisms that (i) become defective in AD to alter the normal...
Articles
Biochem Soc Trans (2011) 39 (5): 1359–1364.
Published: 21 September 2011
...Li-Jun Chen; Elizabeth B. Sawyer; Sarah Perrett Ure2, a regulator of nitrogen metabolism, is the protein determinant of the [ URE3 ] prion state in Saccharomyces cerevisiae . Upon conversion into the prion form, Ure2 undergoes a heritable conformational change to an amyloid-like aggregated state...
Articles
Biochem Soc Trans (2010) 38 (4): 996–1000.
Published: 26 July 2010
...Jean-Pierre Brion; Kunie Ando; Céline Heraud; Karelle Leroy NFTs (neurofibrillary tangles) in Alzheimer's disease and in tauopathies are hallmark neuropathological lesions whose relationship with neuronal dysfunction, neuronal death and with other lesions [such as Aβ (amyloid β-peptide) pathology...
Articles
Biochem Soc Trans (2010) 38 (4): 988–992.
Published: 26 July 2010
... and amyloid in this disease. 1 To whom correspondence should be addressed (email a.mudher@soton.ac.uk ). 26 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 Alzheimer's disease amyloid Drosophila microtubule tauopathy wnt / wingless...
Articles
Biochem Soc Trans (2009) 37 (4): 671–676.
Published: 22 July 2009
... able to take on conformations other than their native fold to form long fibres known as amyloid. In vivo , these are associated with misfolding diseases, such as Alzheimer's disease, Type 2 diabetes and the amyloidoses. In vitro , peptide assembly leads to amyloid-like fibres that have high stability...
Articles
Biochem Soc Trans (2008) 36 (6): 1293–1298.
Published: 19 November 2008
...David Allsop; Jennifer Mayes; Susan Moore; Atef Masad; Brian J. Tabner Using a method based on ESR spectroscopy and spin-trapping, we have shown that Aβ (amyloid β-peptide) (implicated in Alzheimer's disease), α-synuclein (implicated in Parkinson's disease), ABri (British dementia peptide...
Articles
Biochem Soc Trans (2007) 35 (5): 985–990.
Published: 25 October 2007
... amyloid proteins involved in neurodegenerative diseases. It is anticipated that the use of SSNMR in drug discovery will become more widespread in the wake of advances in hardware and methodological developments. 1 email middleda@liv.ac.uk 25 6 2007 © The Authors Journal compilation...
Articles
Biochem Soc Trans (2007) 35 (3): 571–573.
Published: 22 May 2007
...C. Dingwall The amyloidogenic processing pathway of the APP (amyloid precursor protein) generates Aβ (amyloid β-peptide), the major constituent in Alzheimer's disease senile plaques. This processing is catalysed by two unusual membrane-localized aspartic proteinases, β-secretase [BACE1 (β-site APP...
Articles
Biochem Soc Trans (2005) 33 (5): 1106–1110.
Published: 26 October 2005
... cells transfected with α-synuclein (A53T), a familial PD-associated mutation. 1 To whom correspondence should be addressed (email o.elagnaf@uaeu.ac.ae ). 10 8 2005 © 2005 The Biochemical Society 2005 amyloid fibril Parkinson's disease β-sheet-breaker peptide α-synuclein...
Articles
Biochem Soc Trans (2005) 33 (5): 1082–1086.
Published: 26 October 2005
... are present, but in the absence of mature amyloid fibrils. The generation of ROS during early-stage protein aggregation may be a common, fundamental molecular mechanism underlying the pathogenesis of oxidative damage, neurodegeneration and cell death in several different neurodegenerative diseases...
Articles
Biochem Soc Trans (2005) 33 (4): 553–558.
Published: 01 August 2005
...M.N. Pangalos; S.J. Jacobsen; P.H. Reinhart AD (Alzheimer's disease) is characterized neuropathologically by the presence of amyloid plaques, neurofibrillary tangles and profound grey matter loss. The ‘amyloid’ hypothesis postulates that the toxic Aβ (amyloid β) peptide, enzymatically derived from...
Articles
Biochem Soc Trans (2003) 31 (3): 723–727.
Published: 01 June 2003
... neurotoxic Alzheimer's amyloid peptide. The only known homologue of ACE, termed ACE2, is critical to cardiovascular function, but its physiological substrates and precise metabolic roles remain to be elucidated. Other members of these growing metallopeptidase families await further characterization and...
Articles
Biochem Soc Trans (2002) 30 (4): 559–565.
Published: 01 August 2002
...O. M. A. EI-Agnaf; G. B. Irvine Fibrillar deposits of α-synuclein occur in several neurodegenerative diseases. Two mutant forms of α-synuclein have been associated with early-onset Parkinson's disease, and a fragment has been identified as the non-amyloid-β peptide component of Alzheimer's disease...
Articles
Biochem Soc Trans (2001) 29 (4): 617–623.
Published: 01 August 2001
...W. E. Müller; C. Kirsch; G. P. Eckert β-Amyloid (Aβ) protein is the major constituent of senile plaques and cerebrovascular deposits characteristic of Alzheimer's disease (AD). The causal relationship between Aβ and AD-specific lesions like neurodegeneration and atrophy is still not known. The...