... of animal models, which will be fundamental to our complete understanding of AD. 1 To whom correspondence should be addressed (email [email protected] ). 2 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease amyloid β-peptide...

... accumulation of Aβ (amyloid β-peptide), a central event in AD (Alzheimer's disease) synaptic dysfunctions. Structural alterations introduced by site-specific modifications linked to protein aging may affect Aβ production, polymerization and clearance, and therefore play a pivotal role in the pathogenesis...

... in order to determine whether these cholesterol- and isoprenoid-mediated effects are mediated via BACE. amyloid β-peptide β-site amyloid precursor protein-cleaving enzyme (BACE) cholesterol farnesylation palmitoylation β-secretase The production of Aβ (amyloid β-peptide) and its...