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1-14 of 14
Keywords: amyloid β-peptide (Aβ)
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Articles
Mechanisms of small-molecule binding to intrinsically disordered proteins
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1004–1008.
Published: 19 September 2012
... [email protected] ). 11 4 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 amyloid β-peptide (Aβ) intrinsically disordered protein c-Myc small molecule α-synuclein The cell machinery is controlled by a large number of interactions between proteins...
Articles
Twice is better: highlights of the second meeting focused on tau biology and pathology
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 641–643.
Published: 20 July 2012
.... Organized and Edited by Amritpal Mudher (Southampton, U.K.) and Makis Skoulakis (BSRC Alexander Fleming, Greece). © The Authors Journal compilation © 2012 Biochemical Society 2012 Alzheimer's disease amyloid β-peptide (Aβ) tau tauopathy Aβ amyloid β-peptide AD Alzheimer's...
Articles
Luminescent conjugated poly- and oligo-thiophenes: optical ligands for spectral assignment of a plethora of protein aggregates
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 704–710.
Published: 20 July 2012
... the promising results obtained for the recently presented LCOs. 1 To whom correspondence should be addressed (email [email protected] ). 8 2 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 amyloid β-peptide (Aβ) conjugated polymer luminescent conjugated...
Articles
Hippocampal synaptic activity, pattern separation and episodic-like memory: implications for mouse models of Alzheimer's disease pathology
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 902–909.
Published: 20 July 2011
... and the frontal cortex respectively (see [ 42 ] for a recent review). 2 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) dentate gyrus (DG) episodic-like memory hippocampal synaptic activity pattern separation...
Articles
Models of Dementia: an introductory overview
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 851–856.
Published: 20 July 2011
... of the field in general. 1 To whom correspondence should be addressed (email [email protected] ). 13 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease amyloid β-peptide (Aβ) dementia disease model molecular pathology...
Articles
The amyloid cascade hypothesis has misled the pharmaceutical industry
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 920–923.
Published: 20 July 2011
... Alzheimer's disease amyloid β-peptide (Aβ) amyloid cascade hypothesis dementia pharmaceutical industry I strongly urge you all to consider more than the amyloid cascade hypothesis in order to understand what is really going on in idiopathic disease. John Hardy : I am here to talk about...
Articles
Axon–glial disruption: the link between vascular disease and Alzheimer's disease?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 881–885.
Published: 20 July 2011
... The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) axon–glial integrity hypoperfusion vascular disease white matter The integrity of the white matter is critical in regulating efficient neuronal communication and maintaining...
Articles
‘Alzheimer-like’ pathology in a murine model of arterial hypertension
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 939–944.
Published: 20 July 2011
... ). 6 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) arterial hypertension lipopolysaccharide murine model AD is the leading cause of dementia in the elderly and, although some treatments help...
Articles
Intraneuronal Aβ as a trigger for neuron loss: can this be translated into human pathology?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 857–861.
Published: 20 July 2011
... compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) amyloid precursor protein (APP) human pathology intraneuronal amyloid β-peptide (intraneuronal Aβ) neuron loss Figure 2 Schematic drawing of the generation of Aβ pE3–42 oligomers...
Articles
Systemic inflammation and Alzheimer's disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 898–901.
Published: 20 July 2011
...) amyloid β-peptide (Aβ) central nervous system (CNS) microglial cell systemic inflammation 1 To whom correspondence should be addressed (email [email protected] ). In humans, evidence of communication between systemic inflammation and the CNS (central nervous system) is visible in a range...
Articles
Pathways linking Aβ and tau pathologies
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 993–995.
Published: 26 July 2010
.... CHIP, C-terminus of Hsc70 (heat-shock cognate 70)-interacting protein. 1 To whom correspondence should be addressed (email [email protected] ). 26 1 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 Alzheimer's disease amyloid β-peptide (Aβ...
Articles
Neuroinflammatory changes increase the impact of stressors on neuronal function
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 303–307.
Published: 20 January 2009
.... Deuther-Conrad W. Gartner U. Munch G. β-Amyloid peptide potentiates inflammatory responses induced by lipopolysaccharide, interferon-γ and ‘advanced glycation endproducts’ in a murine microglia cell line Eur. J. Neurosci. 2003 17 813 821 aging amyloid β-peptide (Aβ...
Articles
Synaptic memory mechanisms: Alzheimer's disease amyloid β-peptide-induced dysfunction
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1219–1223.
Published: 25 October 2007
... and synaptic LTD. Alzheimer's disease amyloid β-peptide (Aβ) glutamatergic transmission hippocampus integrin long-term potentiation (LTP) synaptic memory tumour necrosis factor α (TNFα) In striking contrast, TNFα has a disruptive effect on the induction of LTP in the hippocampus ([ 20 – 22...
Articles
Survival signalling in Alzheimer's disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1277–1282.
Published: 25 October 2006
... will be further reviewed below. Alzheimer's disease amyloid β-peptide (Aβ) cytosolic phospholipase A 2 docosahexaenoic acid (DHA) neuron survival soluble amyloid precursor protein (sAPPα) AD (Alzheimer's disease) represents a unique dysfunction and deterioration of the evolutionarily higher...