... compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) amyloid precursor protein (APP) human pathology intraneuronal amyloid β-peptide (intraneuronal Aβ) neuron loss Figure 2 Schematic drawing of the generation of Aβ pE3–42 oligomers...

... spectroscopy showed iron levels to be increased almost 2-fold in single SN neurons in PD (mean neuronal iron 2838 compared with 1611 arbitrary pixel units by imaging, P <0.0001) [ 2 ]. amyloid precursor protein (APP) copper ferritin iron oxidative stress zinc Ferritin is the universal...

... significant amount present in cholesterol-rich microdomains (rafts) within the PM (plasma membrane) where it associates with APP [ 13 , 20 , 22 – 24 ]. β-site amyloid precursor protein-cleaving enzyme (BACE) amyloid precursor protein (APP) Golgi-associated γ-adaptin ear homology domain ADP-ribosylation...

... activity in control and AD brain, considering further the expression of BACE2 in the human brain. 1 To whom correspondence should be addressed (email [email protected] ). 19 2 2007 © 2007 Biochemical Society 2007 amyloid precursor protein (APP) aspartyl protease β-site amyloid...

.... 1 To whom correspondence should be addressed (email [email protected] ). 5 10 2006 © 2007 The Biochemical Society 2007 Alzheimer's disease β-amyloid-cleaving enzyme (BACE) amyloid precursor protein (APP) amyloid precursor-like protein (APLP) γ-secretase therapy...

... responses. Here, I briefly review our current understanding of the biochemical properties and physiological roles of JIP proteins. 1 email [email protected] 19 6 2006 © 2006 The Biochemical Society 2006 amyloid precursor protein (APP) brain c-Jun N-terminal...

... in BACE expression, in post-mortem brain tissue and platelets from individuals with AD. Alzheimer's disease (AD) amyloid precursor protein (APP) β-site amyloid precursor protein-cleaving enzyme (BACE) cholesterol platelet post-mortem brain protease An increase in β-secretase activity would...

... protein (APP) BACE1 (β-secretase 1) fibrillogenesis glycosaminoglycan (GAG) heparan sulphate (HS) AD is characterized by amyloid brain deposits of Aβ (amyloid β-peptide), formed by the cleavage of APP (amyloid precursor protein) APP by β- and γ-secretase. γ-Secretase cleaves the membrane-bound...