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Keywords: amyotrophic lateral sclerosis
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Biochem Soc Trans (2024) 52 (3): 961–972.
Published: 30 May 2024
...Macy L. Sprunger; Meredith E. Jackrel The dysfunction of many RNA-binding proteins (RBPs) that are heavily disordered, including TDP-43 and FUS, are implicated in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). These proteins serve many important roles in the cell...
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Biochem Soc Trans (2023) 51 (2): 797–809.
Published: 06 April 2023
...Mario K. Shammas; Tzu-Hsiang Huang; Derek P. Narendra In the last decade, dominant mutations in the mitochondrial protein CHCHD10 (p.R15L and p.S59L) and its paralog CHCHD2 (p.T61I) were shown to cause familial amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), respectively...
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Biochem Soc Trans (2020) 48 (4): 1795–1806.
Published: 14 August 2020
...Gareth S.A. Wright The efficacy of superoxide dismutase-1 (SOD1) folding impacts neuronal loss in motor system neurodegenerative diseases. Mutations can prevent SOD1 post-translational processing leading to misfolding and cytoplasmic aggregation in familial amyotrophic lateral sclerosis (ALS...
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Biochem Soc Trans (2014) 42 (5): 1270–1274.
Published: 18 September 2014
...Laura Ferraiuolo Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting the motor nerves. At present, there is no effective therapy for this devastating disease and only one Food and Drug Administration (FDA)-approved drug, riluzole, is known to moderately extend...
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Biochem Soc Trans (2014) 42 (5): 1291–1301.
Published: 18 September 2014
... ) . 29 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 Alzheimer’s disease amyotrophic lateral sclerosis glia Huntington’s disease neurodegeneration Parkinson’s disease Neuroglia, represented by highly heterogeneous population of non-excitable cells...
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