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Keyword: aneuploidy
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Articles
Biochem Soc Trans (2019) 47 (1): 425-432.
Published: 07 February 2019
... the sperm head. Generally, screening for overall DNA damage is relatively commonplace in clinics, but aneuploidy assessment is less so and nuclear organisation studies form the basis of academic research. Several studies have focussed on the role of chromosome segregation, nuclear organisation and...
Articles
Biochem Soc Trans (2010) 38 (6): 1698-1703.
Published: 24 November 2010
... chromosome rearrangements prone to bridge at mitotic anaphase. Resolution of chromatin bridge intermediates is likely to contribute greatly to the generation of segmental chromosome amplification events, unbalanced chromosome rearrangements and whole chromosome aneuploidy. Accordingly, telomere-driven...
Articles
Biochem Soc Trans (2010) 38 (6): 1681-1686.
Published: 24 November 2010
... separation of sister chromatids, leading to aneuploidy in aged oocytes and embryos derived from them, cannot be traced back to a single disturbance and mechanism. Instead, analysis of recombination patterns of meiotic chromosomes of spread oocytes from embryonal ovary, and of origins and exchange patterns of...
Articles
Biochem Soc Trans (2010) 38 (6): 1715-1721.
Published: 24 November 2010
...Floris Foijer Chromosome instability (CIN) is the process that leads to aneuploidy, a known hallmark of human tumours for over a century. Nowadays, it is believed that CIN promotes tumorigenesis by shuffling the genome into a malignant order through translocations, amplifications, deletions...
Articles
Biochem Soc Trans (2010) 38 (6): 1650-1654.
Published: 24 November 2010
...Sandra S. Wise; John Pierce Wise, Sr Aneuploidy has recently been proposed as an initiating event for carcinogenesis. There is significant evidence that carcinogenic metals induce aneuploidy. Here we review the mechanisms for how carcinogenic metals may induce aneuploidy and the evidence that...
Articles
Biochem Soc Trans (2010) 38 (6): 1691-1697.
Published: 24 November 2010
... summarized according to endpoint and particle type. These studies show that there are interactions between different types of NMs and tubulins in both acellular and cellular systems. For several types of NMs, the multi-walled carbon nanotubes, amorphous SiO 2 , TiO 2 and CoCr, an induction of aneuploidy was...
Articles
Biochem Soc Trans (2009) 37 (5): 971-975.
Published: 21 September 2009
... kinases in maintaining chromosomal stability. 1 email g.j.p.l.kops@umcutrecht.nl 15 4 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 aneuploidy chromosome kinase kinetochore mitotic checkpoint segregation spindle Faithful segregation of...
Articles
Biochem Soc Trans (2009) 37 (4): 910-913.
Published: 22 July 2009
...John H. Bannon; Margaret M. Mc Gee The role of aneuploidy in tumorigenesis remains poorly understood, although the two have been known to be linked for more than 100 years. Recent studies indicate that aneuploidy can promote tumour cell growth and cell death and that the cellular outcome is...
Articles
Biochem Soc Trans (2006) 34 (4): 583-586.
Published: 21 July 2006
... Nup98, which convert into mitotic checkpoint proteins in M-phase, further prevent chromosome missegregation by assembling into a complex with APC Cdh1 and delaying APC Cdh1 -mediated ubiquitination of securin. Disruption of Mad2, BubR1, Bub3 or Rae1 in mice results in substantial aneuploidy in somatic...