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Keyword: angiogenesis
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Articles
Biochem Soc Trans (2019) 47 (5): 1543-1555.
Published: 11 October 2019
... matrix constituents in regulating tumor angiogenesis and provide up-to-date information concerning their primary mechanisms of action. Correspondence: Maurizo Mongiat ( mmongiat@cro.it ) or Renato V. Iozzo ( renato.iozzo@jefferson.edu ) 9 7 2019 22 8 2019 23 9 2019 © 2019 The...
Articles
Biochem Soc Trans (2018) 46 (6): 1673-1680.
Published: 04 December 2018
... under the Creative Commons Attribution License 4.0 (CC BY) . angiogenesis cadherins cell adhesion endothelial cells signalling Blood vessels form complex branched networks consisting of arteries, capillaries and veins that supply oxygen and nutrients to all body tissues [ 1 ]. The...
Articles
Biochem Soc Trans (2016) 44 (4): 1142-1149.
Published: 15 August 2016
...Amaya García de Vinuesa; Matteo Bocci; Kristian Pietras; Peter ten Dijke Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway...
Articles
Biochem Soc Trans (2014) 42 (6): 1569-1575.
Published: 17 November 2014
... compilation © 2014 Biochemical Society 2014 angiogenesis bevacizumab endothelial cell (EC) resistance vascular endothelial growth factor (VEGF) A high level of vascularization was observed in human tumours more than a century ago and the hypothesis that tumours release growth factors to...
Articles
Biochem Soc Trans (2014) 42 (6): 1601-1607.
Published: 17 November 2014
... angiogenesis or compromising the function or stability of pre-existing tumour blood vessels. The vascular endothelial growth factor (VEGF) signalling axis remains the most widely studied, with biological and small-molecule therapeutics now registered for clinical use. However, despite these successes, the...
Articles
Biochem Soc Trans (2014) 42 (6): 1665-1670.
Published: 17 November 2014
... stimulated the Wnt5a/sFlt-1 pathway through enhancing NF-κB signalling. These studies show a novel role for Glrx in post-ischaemic neovascularization, which could define a potential target for therapy of impaired angiogenesis in pathological conditions including diabetes. 1 To whom correspondence...
Articles
Biochem Soc Trans (2014) 42 (6): 1643-1646.
Published: 17 November 2014
... development; however, under conditions of challenge or insult, several phenotypes have emerged. Angiogenesis is an important process both in development and in wound healing, but also in pathologies such as cancer and chronic inflammatory conditions. In the present paper, we summarize the main studies...
Articles
Biochem Soc Trans (2014) 42 (6): 1563-1568.
Published: 17 November 2014
...Thaned Kangsamaksin; Ian W. Tattersall; Jan Kitajewski The Notch signalling pathway is a key regulator of developmental and tumour angiogenesis. Inhibition of Delta-like 4 (Dll4)-mediated Notch signalling results in hyper-sprouting, demonstrating that Notch regulates tip-stalk cell identity in...
Articles
Biochem Soc Trans (2014) 42 (6): 1623-1628.
Published: 17 November 2014
...Anastasia Lampropoulou; Christiana Ruhrberg Blood vessel formation during vertebrate development relies on a process called angiogenesis and is essential for organ growth and tissue viability. In addition, angiogenesis leads to pathological blood vessel growth in diseases with tissue ischaemia...
Articles
Biochem Soc Trans (2014) 42 (6): 1596-1600.
Published: 17 November 2014
...Gordon C. Jayson; Gavin J. Miller; Steen U. Hansen; Marek Barath; John M. Gardiner; Egle Avizienyte Angiogenesis has emerged as a novel target for anti-cancer therapies through randomized clinical trials that tested the benefit of adding vascular endothelial growth factor (VEGF) inhibitors to...
Articles
Biochem Soc Trans (2014) 42 (6): 1658-1664.
Published: 17 November 2014
... regulator of angiogenesis. In this mini-review, we present an overview of the current literature on ELTD1 and present bioinformatics data showing ELTD1's sequence conservation, its expression in cancer cell lines and its mutational frequency in human cancers. Additionally, we present sequence homology...
Articles
Biochem Soc Trans (2014) 42 (6): 1629-1636.
Published: 17 November 2014
...Jaimy Saif; Costanza Emanueli miRNAs are highly conserved non-coding RNA molecules that negatively control gene expression by binding to target mRNAs promoting their degradation. A multitude of miRNAs have been reported to be involved in angiogenesis and vascular remodelling. In the present review...
Articles
Biochem Soc Trans (2014) 42 (6): 1608-1615.
Published: 17 November 2014
... angiogenesis inhibitors can only arise from two efforts. First, through the identification of better targets, preferably specifically expressed in the tumour vasculature. Secondly, through the development of combination therapies. The present review highlights the current efforts and challenges in trying to...
Articles
Biochem Soc Trans (2014) 42 (6): 1584-1589.
Published: 17 November 2014
... cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function. 1 To whom correspondence should be addressed (email...
Articles
Biochem Soc Trans (2014) 42 (6): 1590-1595.
Published: 17 November 2014
... years, studies in β3-integrin-knockout mice have shed some light on possible explanations for disappointing clinical outcomes. However, studying angiogenesis in β3-integrin-knockout mice is a blunt tool to investigate β3-integrin's role in pathological angiogenesis. Since establishing our laboratory at...
Articles
Biochem Soc Trans (2014) 42 (5): 1429-1434.
Published: 18 September 2014
... expression die embryonically and show severe neuronal and cardiovascular defects. Even though the contribution of NRP1 to vascular development has been mainly ascribed to its function as a VEGF-A receptor, recent evidence suggests that NRP1 contributes to angiogenesis through VEGF-independent mechanisms. In...
Articles
Biochem Soc Trans (2014) 42 (5): 1378-1382.
Published: 18 September 2014
...@qmul.ac.uk ) . 14 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis cilium endothelial cell phosphatidylinositol 3-phosphate (PI3K) phosphoinositide 3-kinase (PI3K) trafficking Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that...
Articles
Biochem Soc Trans (2014) 42 (3): 697-701.
Published: 22 May 2014
... angiogenesis muscle atrophy neuroprotection neurotrophic factor regeneration Peripheral nerve injuries, defined as those that affect any nerves outside the central nervous system, have been reported to affect 2.8% of trauma patients [ 1 ]. Injuries can range from compression of the nerve with no...
Articles
Biochem Soc Trans (2013) 41 (1): 273-276.
Published: 29 January 2013
... on tumour biology. Of particular interest is the potential role of extracellular vesicles as orchestrators of common features of the malignant tumour microenvironment, e.g. coagulation activation and angiogenesis. 1 To whom correspondence should be addressed (email Mattias.Belting...
Articles
Biochem Soc Trans (2012) 40 (1): 20-25.
Published: 19 January 2012
... such as NRPs (neuropilins) associate with the ligand–receptor signalling complex and modulate the output. Therapeutics to block several of the VEGF signalling components as well as NRP function have been developed with the aim of halting blood vessel formation, angiogenesis, in diseases that involve...
Articles
Biochem Soc Trans (2012) 40 (1): 251-256.
Published: 19 January 2012
... understanding the role of ERK5 in cancer. 1 To whom correspondence should be addressed (email pamela.lochhead@babraham.ac.uk ). 25 7 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiogenesis cancer extracellular-signal-regulated kinase 5 (ERK5) microRNA...
Articles
Biochem Soc Trans (2011) 39 (6): 1551-1555.
Published: 21 November 2011
...Stuart Egginton; Roy Bicknell Capillaries have been recognized for over a century as one of the most important components in regulating tissue oxygen transport, and their formation or angiogenesis a pivotal element of tissue remodelling during development and adaptation. Clinical interest stems...
Articles
Biochem Soc Trans (2011) 39 (6): 1583-1591.
Published: 21 November 2011
... which are beginning to generate insights into these questions. 1 email i.zachary@ucl.ac.uk 5 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis endothelium neuropilin-1 platelet-derived growth factor (PDGF) receptor tyrosine kinase...
Articles
Biochem Soc Trans (2011) 39 (6): 1592-1596.
Published: 21 November 2011
...Harprit Singh; Tariq A. Tahir; Deborah O.A. Alawo; Eyad Issa; Nicholas P.J. Brindle The angiopoietins act through the endothelial receptor tyrosine kinase Tie2 to regulate vessel maturation in angiogenesis and control quiescence and stability of established vessels. The activating ligand, Ang1...
Articles
Biochem Soc Trans (2011) 39 (6): 1628-1632.
Published: 21 November 2011
...Thomas Gustafsson Exercise-induced angiogenesis in skeletal muscle involves both non-sprouting and sprouting angiogenesis and results from the integrated responses of multiple systems and stimuli. VEGF-A (vascular endothelial growth factor A) levels are increased in exercised muscle and have been...
Articles
Biochem Soc Trans (2011) 39 (6): 1597-1600.
Published: 21 November 2011
...Clare Hetheridge; Georgia Mavria; Harry Mellor Angiogenesis is a complex process that involves multiple cellular events. In addition to receiving inputs from a range of stimulatory and inhibitory factors, endothelial cells undergoing angiogenesis make multiple interactions with the extracellular...
Articles
Biochem Soc Trans (2011) 39 (6): 1659-1666.
Published: 21 November 2011
... the ENG (endoglin) or the ACVRL1 (activin receptor-like kinase 1) gene. Both genes are essential for angiogenesis during development and mice that are homozygous for mutations in Eng or Acvrl1 die in mid-gestation from vascular defects. Recent development of conditional mouse models in which the Eng...
Articles
Biochem Soc Trans (2011) 39 (6): 1601-1605.
Published: 21 November 2011
... were also found to be expressed in endothelial cells in the late 1990s. The early endothelial focus of PPARs was PPARγ, the molecular target for the insulin-sensitizing thiazolidinedione/glitazone class of drugs. Activation of PPARγ was shown to inhibit angiogenesis in vitro and in models of...
Articles
Biochem Soc Trans (2011) 39 (6): 1560-1564.
Published: 21 November 2011
...Andreas Bikfalvi; Michel Moenner; Sophie Javerzat; Sophie North; Martin Hagedorn Angiogenesis has become a major target in cancer therapy. However, current therapeutic strategies have their limitations and raise several problems. In most tumours, anti-angiogenesis treatment targeting VEGF (vascular...
Articles
Biochem Soc Trans (2011) 39 (6): 1565-1570.
Published: 21 November 2011
... functions other than those associated with the nervous system, and indeed many studies have now indicated that Sema3 proteins and their receptors play a role in angiogenesis. The present review specifically focuses on recent evidence for this role in both physiological and pathological angiogenesis. 1...
Articles
Biochem Soc Trans (2011) 39 (6): 1606-1611.
Published: 21 November 2011
... reports of its role in endothelial cells and angiogenesis. 1 To whom correspondence should be addressed (email v.heath@bham.ac.uk ). 10 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 actomyosin contractility angiogenesis endothelium focal adhesion...
Articles
Biochem Soc Trans (2011) 39 (6): 1571-1575.
Published: 21 November 2011
...’. 2 To whom correspondence should be addressed (email r.bicknell@bham.ac.uk ). 23 9 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis C-type lectin 14A (CLEC14A) endothelial cell-specific chemotaxis regulator (ECSCR) roundabout 4 (Robo4...
Articles
Biochem Soc Trans (2011) 39 (6): 1649-1653.
Published: 21 November 2011
... destabilization of this plaque. Cellular and molecular approaches are studied by in vitro assay of activated endothelial cells and in in vivo models of neovascularization. Chemokines are a large family of small secreted proteins that have been shown to play a critical role in the regulation of angiogenesis during...
Articles
Biochem Soc Trans (2011) 39 (6): 1612-1618.
Published: 21 November 2011
...Chern Ein Oon; Adrian L. Harris Notch signalling is a key pathway controlling angiogenesis in normal tissues and tumours. This has become a major focus of development of anticancer therapy, but to develop this appropriately, we need further understanding of the mechanisms of regulation of Dll4...
Articles
Biochem Soc Trans (2011) 39 (5): 1376-1381.
Published: 21 September 2011
...Wei Zhuo; Xiaomin Song; Hao Zhou; Yongzhang Luo ADI (arginine deiminase), an enzyme that hydrolyses arginine, has been reported as an anti-angiogenesis agent. However, its molecular mechanism is unclear. We have demonstrated for the first time that ADI modulates the angiogenic activity of...
Includes: Supplementary data
Articles
Biochem Soc Trans (2011) 39 (2): 688-693.
Published: 22 March 2011
... correspondence should be addressed (email evelyn.murphy@ucd.ie ). 29 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 acute inflammation angiogenesis chronic inflammation cytokine macrophage polarization nuclear receptor Chronic inflammation and...
Articles
Biochem Soc Trans (2009) 37 (6): 1233-1236.
Published: 19 November 2009
..., controlling arterial cell specification and tip versus stalk cell selection. During sprouting angiogenesis, tip cell formation is the default response to VEGF (vascular endothelial growth factor), whereas the stalk cell phenotype is acquired through Dll4/Notch-mediated lateral inhibition. Precisely how Notch...
Articles
Biochem Soc Trans (2009) 37 (6): 1184-1188.
Published: 19 November 2009
... pathways to cellular events. 1 To whom correspondence should be addressed (email h.mellor@bristol.ac.uk ). 28 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis intracellular trafficking vascular endothelial growth factor (VEGF...
Articles
Biochem Soc Trans (2009) 37 (6): 1207-1213.
Published: 19 November 2009
... associated with abnormal angiogenesis (cancer, diabetic retinopathy, retinal vein occlusion, the Denys–Drash syndrome and pre-eclampsia). Administration of recombinant VEGF 165 b inhibits ocular angiogenesis in mouse models of retinopathy and age-related macular degeneration, and colorectal carcinoma and...
Articles
Biochem Soc Trans (2009) 37 (6): 1214-1217.
Published: 19 November 2009
... critical role in endothelial biology and angiogenesis. Two such genes are the roundabout receptor Robo4 and the ECSCR (endothelial-cell-specific chemotaxis regulator). Endothelial cells express both Robo1 and Robo4, which we have knocked down using siRNA (small interfering RNA) and then studied the effect...
Articles
Biochem Soc Trans (2009) 37 (6): 1189-1192.
Published: 19 November 2009
...Nader Rahimi Regulation of angiogenesis is often viewed as a balance between pro-angiogenic and anti-angiogenic factors, and when the balance shifts in favour of angiogenesis stimulators, an angiogenic switch turns on the normally inactive endothelial cells to grow new blood vessels. Recent studies...
Articles
Biochem Soc Trans (2009) 37 (6): 1171-1178.
Published: 19 November 2009
... partners. 1 To whom correspondence should be addressed (email i.zachary@ucl.ac.uk ). 25 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis cancer neuron semaphorin vascular endothelial growth factor (VEGF) NRP1 (neuropilin-1) and the...
Articles
Biochem Soc Trans (2009) 37 (6): 1254-1259.
Published: 19 November 2009
... is required for preventing apoptosis, mediating shear-stress signalling, regulating hypoxia, tumour angiogenesis and cell migration. This review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function. 1 To whom correspondence should be addressed (email...
Articles
Biochem Soc Trans (2009) 37 (6): 1179-1183.
Published: 19 November 2009
...Caroline P.D. Wheeler-Jones; Charlotte Farrar; Elena Garonna COX (cyclo-oxygenase)-2 and members of the PAR (protease-activated receptor) family (PARs 1–4) are highly overexpressed in a number of angiogenesis-dependent pathologies, including advanced atherosclerosis and cancer. An appreciation of...
Articles
Biochem Soc Trans (2009) 37 (6): 1193-1197.
Published: 19 November 2009
... utilized by endothelial cells to sense a key cytokine in vascular tissues. 1 To whom correspondence should be addressed (email s.ponnambalam@leeds.ac.uk ). 6 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis proteolysis receptor...
Articles
Biochem Soc Trans (2009) 37 (6): 1243-1247.
Published: 19 November 2009
... associated with abnormal angiogenesis but the mechanisms are poorly understood. Recent studies show that altering ADMA metabolism in vivo and in vitro modulates the activity of Rho GTPases, key regulators of actin dynamics, endothelial cell motility and angiogenesis. In the present review, we consider this...
Articles
Biochem Soc Trans (2009) 37 (6): 1167-1170.
Published: 19 November 2009
... basis of VEGF resistance in diabetes mellitus. 1 email j.waltenberger@mumc.nl 7 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis arteriogenesis diabetes mellitus endothelial dysfunction signal transduction vascular endothelial growth...
Articles
Biochem Soc Trans (2009) 37 (6): 1198-1200.
Published: 19 November 2009
...Seppo Ylä-Herttuala Therapeutic angiogenesis is a promising new concept for the treatment of myocardial and peripheral ischaemia. Members of the VEGF (vascular endothelial growth factor) family are among the most powerful modulators of angiogenesis. They regulate vascular growth and maintenance...
Articles
Biochem Soc Trans (2009) 37 (6): 1248-1253.
Published: 19 November 2009
...Anna M. Randi; Andrea Sperone; Nicola H. Dryden; Graeme M. Birdsey Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally...
Articles
Biochem Soc Trans (2008) 36 (4): 629-631.
Published: 22 July 2008
... adult cancer. 1 To whom correspondence should be addressed (email Joerg.Hartkamp@manchester.ac.uk ). 28 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 angiogenesis apoptosis development oncogene Wilms' tumour suppressor (WT1) The WT1...