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Keywords: angiogenesis
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Articles
Extracellular matrix: the gatekeeper of tumor angiogenesis
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1543–1555.
Published: 11 October 2019
... matrix constituents in regulating tumor angiogenesis and provide up-to-date information concerning their primary mechanisms of action. Figure 3. Multimerin-2 in gastric cancer. ( A ) Immunofluorescence analysis of Multimerin-2 expression (MMRN2, green) in the vessels of the normal and NEOPLASTIC...
Articles
The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1673–1680.
Published: 04 December 2018
...; however, the vast majority of vessels are formed through a process referred to as angiogenesis, where new vessels sprout from the pre-existing vasculature. As development progresses, vessels undergo active remodelling to ultimately form a stable, mature vessel network. Vasculogenesis, angiogenesis...
Articles
Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1142–1149.
Published: 15 August 2016
...Amaya García de Vinuesa; Matteo Bocci; Kristian Pietras; Peter ten Dijke Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway...
Articles
Redefining the role(s) of endothelial αvβ3-integrin in angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1590–1595.
Published: 17 November 2014
... the years, studies in β3-integrin-knockout mice have shed some light on possible explanations for disappointing clinical outcomes. However, studying angiogenesis in β3-integrin-knockout mice is a blunt tool to investigate β3-integrin's role in pathological angiogenesis. Since establishing our laboratory...
Articles
Notch functions in developmental and tumour angiogenesis by diverse mechanisms 1
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1563–1568.
Published: 17 November 2014
...Thaned Kangsamaksin; Ian W. Tattersall; Jan Kitajewski The Notch signalling pathway is a key regulator of developmental and tumour angiogenesis. Inhibition of Delta-like 4 (Dll4)-mediated Notch signalling results in hyper-sprouting, demonstrating that Notch regulates tip-stalk cell identity...
Articles
Neuropilin regulation of angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1623–1628.
Published: 17 November 2014
...Anastasia Lampropoulou; Christiana Ruhrberg Blood vessel formation during vertebrate development relies on a process called angiogenesis and is essential for organ growth and tissue viability. In addition, angiogenesis leads to pathological blood vessel growth in diseases with tissue ischaemia...
Articles
The development of anti-angiogenic heparan sulfate oligosaccharides
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1596–1600.
Published: 17 November 2014
...Gordon C. Jayson; Gavin J. Miller; Steen U. Hansen; Marek Barath; John M. Gardiner; Egle Avizienyte Angiogenesis has emerged as a novel target for anti-cancer therapies through randomized clinical trials that tested the benefit of adding vascular endothelial growth factor (VEGF) inhibitors...
Articles
A review of ELTD1, a pro-angiogenic adhesion GPCR
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1658–1664.
Published: 17 November 2014
... regulator of angiogenesis. In this mini-review, we present an overview of the current literature on ELTD1 and present bioinformatics data showing ELTD1's sequence conservation, its expression in cancer cell lines and its mutational frequency in human cancers. Additionally, we present sequence homology...
Articles
miRNAs in post-ischaemic angiogenesis and vascular remodelling
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1629–1636.
Published: 17 November 2014
...Jaimy Saif; Costanza Emanueli miRNAs are highly conserved non-coding RNA molecules that negatively control gene expression by binding to target mRNAs promoting their degradation. A multitude of miRNAs have been reported to be involved in angiogenesis and vascular remodelling. In the present review...
Articles
Exploring the role of endothelium in the tumour response to anti-angiogenic therapy
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1569–1575.
Published: 17 November 2014
... ). 12 6 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis bevacizumab endothelial cell (EC) resistance vascular endothelial growth factor (VEGF) A high level of vascularization was observed in human tumours more than a century ago...
Articles
Mechanisms that influence tumour response to VEGF-pathway inhibitors
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1601–1607.
Published: 17 November 2014
...Neil R. Smith; Stephen R. Wedge; Aurelien Pommier; Simon T. Barry There has been significant investment in developing novel therapies to target solid tumour vasculature. Different technical approaches have been utilized with the aim of inhibiting tumour angiogenesis or compromising the function...
Articles
Syndecans in angiogenesis and endothelial cell biology
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1643–1646.
Published: 17 November 2014
... development; however, under conditions of challenge or insult, several phenotypes have emerged. Angiogenesis is an important process both in development and in wound healing, but also in pathologies such as cancer and chronic inflammatory conditions. In the present paper, we summarize the main studies...
Articles
Regulation of neovascularization by S-glutathionylation via the Wnt5a/sFlt-1 pathway
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1665–1670.
Published: 17 November 2014
... stimulated the Wnt5a/sFlt-1 pathway through enhancing NF-κB signalling. These studies show a novel role for Glrx in post-ischaemic neovascularization, which could define a potential target for therapy of impaired angiogenesis in pathological conditions including diabetes. VEGF is the major factor...
Articles
The emerging quest for the optimal angiostatic combination therapy
Available to PurchaseArjan W. Griffioen, Andrea Weiss, Robert H. Berndsen, U. Kulsoom Abdul, Marije T. te Winkel, Patrycja Nowak-Sliwinska
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1608–1615.
Published: 17 November 2014
... angiogenesis inhibitors can only arise from two efforts. First, through the identification of better targets, preferably specifically expressed in the tumour vasculature. Secondly, through the development of combination therapies. The present review highlights the current efforts and challenges in trying...
Articles
The role of ERK5 in endothelial cell function
Available to PurchaseGopika N. Nithianandarajah-Jones, Bettina Wilm, Christopher E.P. Goldring, Jürgen Müller, Michael J. Cross
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1584–1589.
Published: 17 November 2014
... cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function. 1 To whom correspondence should be addressed (email...
Articles
New insight into the intracellular roles of class II phosphoinositide 3-kinases
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (5): 1378–1382.
Published: 18 September 2014
... retinal angiogenesis and increased apoptosis in retinas upon tamoxifen administration, consistent with in vitro data. These data indicate that PI3K-C2α is also critical for postnatal physiological angiogenesis [ 10 ]. 1 To whom correspondence should be addressed (email [email protected]...
Articles
Neuropilin-1 enforces extracellular matrix signalling via ABL1 to promote angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (5): 1429–1434.
Published: 18 September 2014
... expression die embryonically and show severe neuronal and cardiovascular defects. Even though the contribution of NRP1 to vascular development has been mainly ascribed to its function as a VEGF-A receptor, recent evidence suggests that NRP1 contributes to angiogenesis through VEGF-independent mechanisms...
Articles
Regenerative effects of adipose-tissue-derived stem cells for treatment of peripheral nerve injuries
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (3): 697–701.
Published: 22 May 2014
... alternative to the nerve graft. 7 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 adipose-tissue-derived stem cell angiogenesis muscle atrophy neuroprotection neurotrophic factor regeneration Angiogenesis has long been recognized as being critical...
Articles
Role of extracellular membrane vesicles in intercellular communication of the tumour microenvironment
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 273–276.
Published: 29 January 2013
... on tumour biology. Of particular interest is the potential role of extracellular vesicles as orchestrators of common features of the malignant tumour microenvironment, e.g. coagulation activation and angiogenesis. 1 To whom correspondence should be addressed (email [email protected]...
Articles
Neuropilin signalling in angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 20–25.
Published: 19 January 2012
... such as NRPs (neuropilins) associate with the ligand–receptor signalling complex and modulate the output. Therapeutics to block several of the VEGF signalling components as well as NRP function have been developed with the aim of halting blood vessel formation, angiogenesis, in diseases that involve tissue...
Articles
ERK5 and its role in tumour development
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 251–256.
Published: 19 January 2012
... ] as a framework, discuss the evidence for ERK5 activation by oncogenes and consider the mechanisms that regulate ERK5 protein levels. © The Authors Journal compilation © 2012 Biochemical Society 2012 angiogenesis cancer extracellular-signal-regulated kinase 5 (ERK5) microRNA (miRNA) migration...
Articles
Angiogenic properties of the chemokine RANTES/CCL5
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1649–1653.
Published: 21 November 2011
... in the destabilization of this plaque. Cellular and molecular approaches are studied by in vitro assay of activated endothelial cells and in in vivo models of neovascularization. Chemokines are a large family of small secreted proteins that have been shown to play a critical role in the regulation of angiogenesis during...
Articles
The role of RhoJ in endothelial cell biology and angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1606–1611.
Published: 21 November 2011
... reports of its role in endothelial cells and angiogenesis. 1 To whom correspondence should be addressed (email [email protected] ). 10 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 actomyosin contractility angiogenesis endothelium focal adhesion...
Articles
Shear stress, tip cells and regulators of endothelial migration
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1571–1575.
Published: 21 November 2011
... correspondence should be addressed (email [email protected] ). Figure 1 Low shear stress induces expression of Robo4 and CLEC14A and initiates a tip cell phenotype from a phalanx cell Sprouting angiogenesis: formation of new blood vessels through degradation of basement membrane by proteases...
Articles
New pathways and mechanisms regulating and responding to Delta-like ligand 4–Notch signalling in tumour angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1612–1618.
Published: 21 November 2011
...Chern Ein Oon; Adrian L. Harris Notch signalling is a key pathway controlling angiogenesis in normal tissues and tumours. This has become a major focus of development of anticancer therapy, but to develop this appropriately, we need further understanding of the mechanisms of regulation of Dll4...
Articles
Advances in the Cellular and Molecular Biology of Angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1551–1555.
Published: 21 November 2011
...Stuart Egginton; Roy Bicknell Capillaries have been recognized for over a century as one of the most important components in regulating tissue oxygen transport, and their formation or angiogenesis a pivotal element of tissue remodelling during development and adaptation. Clinical interest stems...
Articles
How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1583–1591.
Published: 21 November 2011
... or chemoattraction in VEGF-treated ECs [ 9 – 13 ]. angiogenesis endothelium neuropilin-1 platelet-derived growth factor (PDGF) receptor tyrosine kinase vascular endothelial growth factor (VEGF) NRP (neuropilin) 1 and the related molecule NRP2 are receptors for two unrelated types of polypeptide...
Articles
Molecular control of angiopoietin signalling
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1592–1596.
Published: 21 November 2011
...Harprit Singh; Tariq A. Tahir; Deborah O.A. Alawo; Eyad Issa; Nicholas P.J. Brindle The angiopoietins act through the endothelial receptor tyrosine kinase Tie2 to regulate vessel maturation in angiogenesis and control quiescence and stability of established vessels. The activating ligand, Ang1...
Articles
Vascular remodelling in human skeletal muscle
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1628–1632.
Published: 21 November 2011
...Thomas Gustafsson Exercise-induced angiogenesis in skeletal muscle involves both non-sprouting and sprouting angiogenesis and results from the integrated responses of multiple systems and stimuli. VEGF-A (vascular endothelial growth factor A) levels are increased in exercised muscle and have been...
Articles
Uses of the in vitro endothelial–fibroblast organotypic co-culture assay in angiogenesis research
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1597–1600.
Published: 21 November 2011
...Clare Hetheridge; Georgia Mavria; Harry Mellor Angiogenesis is a complex process that involves multiple cellular events. In addition to receiving inputs from a range of stimulatory and inhibitory factors, endothelial cells undergoing angiogenesis make multiple interactions with the extracellular...
Articles
Angiogenesis regulation by TGFβ signalling: clues from an inherited vascular disease
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1659–1666.
Published: 21 November 2011
... the ENG (endoglin) or the ACVRL1 (activin receptor-like kinase 1) gene. Both genes are essential for angiogenesis during development and mice that are homozygous for mutations in Eng or Acvrl1 die in mid-gestation from vascular defects. Recent development of conditional mouse models in which the Eng...
Articles
PPARs and angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1601–1605.
Published: 21 November 2011
..., but were also found to be expressed in endothelial cells in the late 1990s. The early endothelial focus of PPARs was PPARγ, the molecular target for the insulin-sensitizing thiazolidinedione/glitazone class of drugs. Activation of PPARγ was shown to inhibit angiogenesis in vitro and in models...
Articles
Inhibition of angiogenesis and the angiogenesis/invasion shift
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1560–1564.
Published: 21 November 2011
...Andreas Bikfalvi; Michel Moenner; Sophie Javerzat; Sophie North; Martin Hagedorn Angiogenesis has become a major target in cancer therapy. However, current therapeutic strategies have their limitations and raise several problems. In most tumours, anti-angiogenesis treatment targeting VEGF (vascular...
Articles
Class 3 semaphorins and their receptors in physiological and pathological angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1565–1570.
Published: 21 November 2011
... functions other than those associated with the nervous system, and indeed many studies have now indicated that Sema3 proteins and their receptors play a role in angiogenesis. The present review specifically focuses on recent evidence for this role in both physiological and pathological angiogenesis...
Articles
Arginine deiminase modulates endothelial tip cells via excessive synthesis of reactive oxygen species
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1376–1381.
Published: 21 September 2011
...Wei Zhuo; Xiaomin Song; Hao Zhou; Yongzhang Luo ADI (arginine deiminase), an enzyme that hydrolyses arginine, has been reported as an anti-angiogenesis agent. However, its molecular mechanism is unclear. We have demonstrated for the first time that ADI modulates the angiogenic activity...
Includes: Supplementary data
Articles
Inflammation: a role for NR4A orphan nuclear receptors?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (2): 688–693.
Published: 22 March 2011
... [email protected] ). 29 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 acute inflammation angiogenesis chronic inflammation cytokine macrophage polarization nuclear receptor Polarization and priming of immune cells are of significant importance...
Articles
The role of neuropilins in cell signalling
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1171–1178.
Published: 19 November 2009
... partners. 1 To whom correspondence should be addressed (email [email protected] ). 25 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis cancer neuron semaphorin vascular endothelial growth factor (VEGF) NRP1 (neuropilin-1...
Articles
ERK5 and the regulation of endothelial cell function
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1254–1259.
Published: 19 November 2009
... is required for preventing apoptosis, mediating shear-stress signalling, regulating hypoxia, tumour angiogenesis and cell migration. This review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function. 1 To whom correspondence should be addressed (email...
Articles
Protease-activated receptors, cyclo-oxygenases and pro-angiogenic signalling in endothelial cells
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1179–1183.
Published: 19 November 2009
...Caroline P.D. Wheeler-Jones; Charlotte Farrar; Elena Garonna COX (cyclo-oxygenase)-2 and members of the PAR (protease-activated receptor) family (PARs 1–4) are highly overexpressed in a number of angiogenesis-dependent pathologies, including advanced atherosclerosis and cancer. An appreciation...
Articles
VEGFRs and Notch: a dynamic collaboration in vascular patterning
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1233–1236.
Published: 19 November 2009
..., controlling arterial cell specification and tip versus stalk cell selection. During sprouting angiogenesis, tip cell formation is the default response to VEGF (vascular endothelial growth factor), whereas the stalk cell phenotype is acquired through Dll4/Notch-mediated lateral inhibition. Precisely how Notch...
Articles
VEGF receptor trafficking in angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1184–1188.
Published: 19 November 2009
... pathways to cellular events. 1 To whom correspondence should be addressed (email [email protected] ). 28 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis intracellular trafficking vascular endothelial growth factor (VEGF...
Articles
The anti-angiogenic isoforms of VEGF in health and disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1207–1213.
Published: 19 November 2009
... associated with abnormal angiogenesis (cancer, diabetic retinopathy, retinal vein occlusion, the Denys–Drash syndrome and pre-eclampsia). Administration of recombinant VEGF 165 b inhibits ocular angiogenesis in mouse models of retinopathy and age-related macular degeneration, and colorectal carcinoma...
Articles
Gene therapy with vascular endothelial growth factors
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1198–1200.
Published: 19 November 2009
...Seppo Ylä-Herttuala Therapeutic angiogenesis is a promising new concept for the treatment of myocardial and peripheral ischaemia. Members of the VEGF (vascular endothelial growth factor) family are among the most powerful modulators of angiogenesis. They regulate vascular growth and maintenance...
Articles
Functionally defining the endothelial transcriptome, from Robo4 to ECSCR
Available to PurchaseAna Raquel Verissimo, John M.J. Herbert, Victoria L. Heath, John A. Legg, Helen Sheldon, Maud Andre, Rajeeb Kumar Swain, Roy Bicknell
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1214–1217.
Published: 19 November 2009
... a critical role in endothelial biology and angiogenesis. Two such genes are the roundabout receptor Robo4 and the ECSCR (endothelial-cell-specific chemotaxis regulator). Endothelial cells express both Robo1 and Robo4, which we have knocked down using siRNA (small interfering RNA) and then studied the effect...
Articles
A role for protein ubiquitination in VEGFR-2 signalling and angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1189–1192.
Published: 19 November 2009
...Nader Rahimi Regulation of angiogenesis is often viewed as a balance between pro-angiogenic and anti-angiogenic factors, and when the balance shifts in favour of angiogenesis stimulators, an angiogenic switch turns on the normally inactive endothelial cells to grow new blood vessels. Recent studies...
Articles
VEGF-A-stimulated signalling in endothelial cells via a dual receptor tyrosine kinase system is dependent on co-ordinated trafficking and proteolysis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1193–1197.
Published: 19 November 2009
... to sense a key cytokine in vascular tissues. 6 7 2009 Molecular and Cellular Mechanisms of Angiogenesis: Biochemical Society Focused Meeting held at University of Chester, Chester, U.K., 15–17 July 2009. Organized and Edited by Ian Zachary (University College London, U.K.) and Sreenivasan...
Articles
The DDAH/ADMA pathway in the control of endothelial cell migration and angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1243–1247.
Published: 19 November 2009
... associated with abnormal angiogenesis but the mechanisms are poorly understood. Recent studies show that altering ADMA metabolism in vivo and in vitro modulates the activity of Rho GTPases, key regulators of actin dynamics, endothelial cell motility and angiogenesis. In the present review, we consider...
Articles
VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1167–1170.
Published: 19 November 2009
... basis of VEGF resistance in diabetes mellitus. 7 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis arteriogenesis diabetes mellitus endothelial dysfunction signal transduction vascular endothelial growth factor (VEGF) 1 email...
Articles
Regulation of angiogenesis by ETS transcription factors
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1248–1253.
Published: 19 November 2009
...Anna M. Randi; Andrea Sperone; Nicola H. Dryden; Graeme M. Birdsey Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally...
Articles
The role of the Wilms' tumour-suppressor protein WT1 in apoptosis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (4): 629–631.
Published: 22 July 2008
...-inducible factor)-1 [ 37 ]. Furthermore, WT1 is involved in endothelial cell proliferation, vascular formation and migration, indicating that it might be a general marker for angiogenesis [ 38 ]. The fact that oncogenic WT1 expression seems to be tumour-specific makes it a good target for therapeutic...
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