..., autolysins initiate emergency processes, including programmed cell death (PCD), in which a subpopulation dies to benefit the community by providing nutrients ( Figure 3 ) [ 83 , 84 ]. PCD indirectly contributes to antibiotic resistance through ‘necrosignals’ released after lysis. For example, release...

... ) 30 4 2024 3 6 2024 4 6 2024 © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 antibiotic hyper-resistance antibiotic resistance isoleucyl-tRNA synthetase mupirocin protein synthesis Mupirocin (pseudomonic acid...

...Callaghan Cylke; Fangwei Si; Shiladitya Banerjee Characterizing the physiological response of bacterial cells to antibiotic treatment is crucial for the design of antibacterial therapies and for understanding the mechanisms of antibiotic resistance. While the effects of antibiotics are commonly...

... to different repair pathway choices, heterogeneity in DNA damage responses, and ultimately diversity in cell fates. antibiotic resistance DNA replication and recombination DNA synthesis and repair mutagenesis phenotypic heterogeneity single-cell analysis The maintenance of genome integrity...

... of neighbouring promoters. We suggest that many bacterial promoters might be susceptible to similar position-dependent effects and we review recent data showing that the expression of mobile genes encoding antibiotic-resistance determinants is also location-dependent, both when carried on a bacterial chromosome...

...Ciara Tyrrell; Catherine M. Burgess; Fiona P. Brennan; Fiona Walsh Antibiotic resistance is currently one of the greatest threats to human health. The global overuse of antibiotics in human medicine and in agriculture has resulted in the proliferation and dissemination of a multitude of antibiotic...

.... As a result, both types of mutations reduce RMP-binding affinity [ 48 ]. antibiotic resistance antibiotics mechanism of action of antibiotics rifampicin RNA polymerase transcription Antibiotic resistant infections represent a growing threat to human life. However, few novel antibiotics have...

... such as Crohn's disease. 1 To whom correspondence should be addressed (email [email protected] ). 14 9 2012 © 2012 The Authors Journal 2012 antibiotic resistance biofilm colicin Crohn's disease Pseudomonas pyocin Antibiotic resistance is recognized...

... to host and antibiotic selection pressure, and this is achieved by point mutations. Almost all antibiotic resistance emerges in this way, and data from clinical and in vitro studies indicate that M. tuberculosis exists with pre-existent mutants that remain as a small proportion of the population because...

... ). Enzyme Mechanism – A Structural Perspective, a Biochemical Society Focused Meeting held at St. Andrews University, 12–14 January 2003 16 December 2002 © 2003 Biochemical Society 2003 acetyltransferase aminoglycoside antibiotic resistance Mycobacterium tuberculosis Salmonella...