... chemoattractants that induces neutrophil infiltration into infected or injured tissues. Sdc1 ectodomains also bind to cationic antimicrobial peptides and inhibit their ability to kill bacterial pathogens in an HS-dependent manner [ 18 , 39 ]. Furthermore, in a mouse model of bacterial keratitis, the ability...

... ]. Lantibiotics are ribosomally synthesized antimicrobial peptides produced by Gram-positive bacteria that are characterized by the presence of lanthionine and/or methyllanthionine residues, introduced by a series of enzyme-mediated post-translational modifications of a linear inactive precursor peptide [ 2 – 4...

... with AMPs (antimicrobial peptides), the interplay between charge and hydrophobic character of the nuclease domains governs their pleiotropic membrane activities and these results form the basis of ongoing work to unravel the molecular mechanisms underlying their membrane translocation. AMPs, small...

... are antimicrobial peptides. In the present review, we provide an overview of antifungal peptides isolated from plants, insects, amphibians and mammals that induce apoptosis. Their antifungal spectrum, mode of action and toxicity are discussed in more detail. 1 To whom correspondence should be addressed...

... Cytokine 2008 42 145 151 © The Authors Journal compilation © 2011 Biochemical Society 2011 antimicrobial peptide bacterium lipopolysaccharide (LPS) mucous cell serous cell short palate lung and nasal epithelium clone 1 (SPLUNC1) The impact of antimicrobial activity...

...-regensburg.de ). 17 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 antimicrobial peptide bactericidal/permeability-increasing protein (BPI) cystic fibrosis lung innate immunity pneumonia From all existing data we can conclude that BPI is an important...

...K. Aggrawal; N. Silverman Drosophila rely primarily on innate immune responses to effectively combat a wide array of microbial pathogens. The hallmark of the Drosophila humoral immune response is the rapid production of AMPs (antimicrobial peptides) by the fat body, the insect homologue...

... the antibacterial activity of a wide range of antimicrobial peptides and proteins: i.e. lysozyme, SLPI (secretory leucocyte proteinase inhibitor), LL-37, hNP-1 (human neutrophil peptide-1) and the human β-defensins 1, 2 and 3. Analysis of the functional properties of recombinant domains of SIC shows that binding...

...P.S. Hiemstra Innate immunity provides an effective first line of defence against infections. This is of particular importance in the lung, an organ that is exposed to a large number of pathogens that are inhaled. Antimicrobial peptides play an important role in the defence against these pathogens...

... innate immune system produces a large array of weapons to protect the host from the constant attack which it is under from micro-organisms [ 1 ]. One important family is the cationic AMPs (antimicrobial peptides), a vast arsenal of small polypeptides which kill Gram-positive, Gramnegative, fungal...

...-defensins. 1 To whom correspondence should be addressed (email [email protected] ). 5 1 2006 © 2006 The Biochemical Society 2006 antimicrobial peptide β-defensin gene cluster immune defence primate evolution propeptide region Antimicrobial peptides have a critical...