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Keywords: antiviral immunity
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Articles

Mechanisms of impairment of interferon production by SARS-CoV-2

Open Access
In Collection
Coronavirus
Huy-Dung Hoang, Parisa Naeli, Tommy Alain, Seyed Mehdi Jafarnejad
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1047–1056.
https://doi.org/10.1042/BST20221037
Published: 18 May 2023
... impairs the production of IFNs and thereby dampens the host's innate antiviral immune response. Correspondence: Seyed Mehdi Jafarnejad ( [email protected] ) 12 1 2023 2 5 2023 4 5 2023 The SARS-CoV-2 virion contains four structural proteins: spike (S), envelope (E...
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Articles

The pharmacology of endosomal TLR agonists in viral disease

Available to Purchase
D.R. Averett, S.P. Fletcher, W. Li, S.E. Webber, J.R. Appleman
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (6): 1468–1472.
https://doi.org/10.1042/BST0351468
Published: 23 November 2007
... compilation © 2007 Biochemical Society 2007 antiviral immunity imiquimod interferon α (IFNα) isatoribine pattern-recognition receptor Toll-like receptor agonism (TLR agonism) Pharmacological enhancement of immune responses for the treatment of viral disease is attractive for several reasons...
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