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Keywords: apoptosis
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Articles
Biochem Soc Trans (2023) 51 (2): 759–769.
Published: 06 April 2023
... only occurred in the last few decades and is still under intense study. Moreover, it has become increasingly clear that there are multiple types of regulated cell death, distinguished by morphological and molecular signatures, including apoptosis, necroptosis, pyroptosis, and ferroptosis. While...
Articles
Biochem Soc Trans (2023) 51 (1): 457–472.
Published: 23 February 2023
... ) 12 12 2022 2 2 2023 3 2 2023 © 2023 The Author(s) 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cell death mitochondria...
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Biochem Soc Trans (2023) 51 (1): 303–313.
Published: 25 January 2023
...Xiaohui Wang; Larisa I. Labzin Programmed cell death is a critical host defence strategy during viral infection. Neighbouring cells deal with this death in distinct ways depending on how the infected cell dies. While apoptosis is considered immunologically silent, the lytic pathways of necroptosis...
Articles
Biochem Soc Trans (2023) 51 (1): 57–70.
Published: 11 January 2023
... necrosis factor-related apoptosis-inducing ligand (TRAIL) along with its potent and selective antitumor effects initiated a decades-long search for therapeutic strategies to target the TRAIL pathway. First-generation approaches were focused on the development of TRAIL receptor agonists (TRAs), including...
Articles
Biochem Soc Trans (2022) 50 (6): 1583–1594.
Published: 24 November 2022
... inflammatory signalling or inducing programmed cell death activation, ranging from apoptosis, pyroptosis to necroptosis. In this review, we first discuss the mechanisms by which RIPK1 and RIPK3 promote the assembly of death-inducing complexes and how these cell death pathways are activated as host responses...
Articles
Biochem Soc Trans (2022) 50 (5): 1517–1526.
Published: 05 October 2022
... for the DNA replication stress response [ 39 ]. Faithful RNA regulation is also critical for germ cell survival. For example, loss of RNA binding proteins such as CAR-1 and MINA-1 result in a marked increase in apoptosis [ 40 , 41 ]. Disruption of pre-mRNA splicing causes stress in cells by overloading...
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Articles
Biochem Soc Trans (2022) 50 (2): 839–851.
Published: 28 March 2022
... monoclonal antibody was recently shown to increase the susceptibility of several pancreatic cancer cell lines to chemotherapeutics, increase their apoptosis, and decrease their migration. MMP-7 activities are most apparent at the surfaces of innate immune, epithelial, and tumor cells. Proteolytic shedding...
Articles
Biochem Soc Trans (2022) 50 (1): 13–20.
Published: 15 February 2022
... can contribute to autoinflammatory and autoimmune diseases or life-threatening conditions like sepsis. These diseases generally display increased levels of cell death, which, downstream of the TNF receptor, can either be caspase-dependent (apoptosis) or caspase-independent (necroptosis). Significant...
Articles
Biochem Soc Trans (2021) 49 (6): 2787–2795.
Published: 16 December 2021
...Zheng Yuan; Grant Dewson; Peter E. Czabotar; Richard W. Birkinshaw The BCL-2 protein family govern whether a cell dies or survives by controlling mitochondrial apoptosis. As dysregulation of mitochondrial apoptosis is a common feature of cancer cells, targeting protein–protein interactions within...
Articles
Biochem Soc Trans (2021) 49 (5): 2397–2410.
Published: 28 September 2021
...W. Douglas Fairlie; Erinna F. Lee The deregulation of apoptosis is a key contributor to tumourigenesis as it can lead to the unwanted survival of rogue cells. Drugs known as the BH3-mimetics targeting the pro-survival members of the BCL-2 protein family to induce apoptosis in cancer cells have...
Articles
Biochem Soc Trans (2021) 49 (5): 2381–2395.
Published: 13 September 2021
... Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. apoptosis BCL-2 BCL-XL BH3-mimetics MCL-1 The BCL-2 family of proteins consists of functionally opposing, though structurally related proteins [ 1 ]. The founding...
Articles
Biochem Soc Trans (2021) 49 (2): 793–804.
Published: 12 April 2021
... & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. apoptosis cell clearance necroptosis necrosis phagocytosis pyroptosis Apoptosis is largely driven by one of two pathways: the intrinsic/mitochondrial pathway and the extrinsic...
Articles
Biochem Soc Trans (2021) 49 (2): 663–674.
Published: 11 March 2021
... of intermembrane space proteins like cytochrome c , is considered a point of no return in apoptosis. MOMP is controlled by the proteins of the B-cell lymphoma 2 (BCL-2) family, including pro-and anti-apoptotic members, whose balance determines the decision between cell death and survival. Other factors...
Articles
Biochem Soc Trans (2020) 48 (5): 2079–2088.
Published: 01 September 2020
... (ApoBDs), a distinct type of EVs released by cells undergoing a form of programmed cell death called apoptosis, has been largely unexplored. Recent studies have shed light on ApoBD biogenesis and functions, promisingly implicating their therapeutic potential. In this review, we discuss many strategies...
Articles
Biochem Soc Trans (2020) 48 (2): 719–731.
Published: 08 April 2020
... different venoms demonstrate considerable cytotoxic effects on cancer cells via induction of apoptosis, cell cycle arrest and suppression of proliferation. These enzymes produce more pronounced cytotoxic effects in cancer cells than normal cells, thus they can be potential sources as chemotherapeutic agents...
Articles
Biochem Soc Trans (2017) 45 (6): 1213–1223.
Published: 20 October 2017
... and oxidative stress, mitochondrial DNA lesions, electron transfer chain impairments, mitochondrial apoptosis and mitophagy has been outlined. Meanwhile, considerable efforts have been made towards understanding the role of platelet mitochondrial dysfunction in human diseases, such as diabetes mellitus, sepsis...
Articles
Biochem Soc Trans (2017) 45 (1): 123–129.
Published: 15 February 2017
...); published by Portland Press Limited on behalf of the Biochemical Society 2017 apoptosis leucine-rich repeat kinase 2 neuronal death In a disease of complex etiology such as Parkinson's disease (PD), the underlying pathology is equally complex; however, the primary motor dysfunction...
Articles
Biochem Soc Trans (2016) 44 (5): 1531–1540.
Published: 19 October 2016
.... Correspondence: Georgios Psakis ( g.psakis@hud.ac.uk ) 13 5 2016 22 6 2016 28 6 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 amyloid formation apoptosis oligomerisation plants protein aggregation VDAC In 2007...
Articles
Biochem Soc Trans (2015) 43 (4): 715–719.
Published: 03 August 2015
... mediate adherence of Staphylococcus aureus to resting human endothelial cells Microbiology 1999 145 Pt 12 3477 3486 10627045 35 Menzies B.E. Kourteva I. Internalization of Staphylococcus aureus by endothelial cells induces apoptosis Infect. Immun. 1998 66 5994 5998 9826383...
Articles
Biochem Soc Trans (2015) 43 (4): 720–726.
Published: 03 August 2015
... platelets reach as forerunners and function as critical players. 1 To whom correspondence should be addressed (email meinrad.gawaz@med.uni-tuebingen.de ) . 12 5 2015 apoptosis coronary artery disease (CAD) CXCR4 CXCR7 platelet thrombosis Platelet-derived chemokines...
Articles
Biochem Soc Trans (2015) 43 (4): 531–536.
Published: 03 August 2015
... Limited 2015 apoptosis drug design glioblastoma translocator protein Gliomas are a family of highly aggressive brain tumours formed from brain glial cells or their precursors. The most common glioma in adults is glioblastoma multiforme (GM), comprising 60%–70% of all primary brain tumour...
Articles
Biochem Soc Trans (2015) 43 (3): 323–327.
Published: 01 June 2015
... shown to act as an activator and inhibitor of cellular translation and as a positive and negative regulator of mRNA stability, regulating cellular processes such as mitosis and apoptosis. The different post-transcriptional functions of Unr depend on the identity of its mRNA and protein partners and can...
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Biochem Soc Trans (2015) 43 (2): 229–234.
Published: 07 April 2015
... cleavage. It promotes membrane binding and relocalization of functional protein domains released by caspase cleavage during apoptosis, or programmed cell death. However, as the requirement of caspase cleavage has expanded beyond just cell death, it has become apparent that PTMyr may play a role in cell...
Articles
Biochem Soc Trans (2014) 42 (6): 1519–1523.
Published: 17 November 2014
... is to pinpoint the underlying key factors and to develop therapies for their direct targeting. Protein kinase C (PKC) enzymes are promising candidates, as some PKCs were shown to be involved in regulation of apoptosis. Our studies and others have shown that PKCη is an anti-apoptotic kinase, able to confer...
Articles
Biochem Soc Trans (2014) 42 (4): 939–944.
Published: 11 August 2014
...Margaret M. Briehl; Margaret E. Tome; Sarah T. Wilkinson; Melba C. Jaramillo; Kristy Lee Characteristics of cancer cells include a more oxidized redox environment, metabolic reprogramming and apoptosis resistance. Our studies with a lymphoma model have explored connections between the cellular...
Articles
Biochem Soc Trans (2014) 42 (1): 125–129.
Published: 23 January 2014
... are shown in green, and drugs are shown in blue. Autotaxin drives the production of LPA from lysophosphatidylcholine (LPC) which activates survival pathways to suppress chemotherapy-induced apoptosis. Cells are also sensitized to apoptosis by inhibition of Bcl-2 family inhibitors (‘I’) which sequester...
Articles
Biochem Soc Trans (2014) 42 (1): 47–51.
Published: 23 January 2014
...Julea N. Butt Apoptosis is triggered by an accumulation of ROS (reactive oxygen species) produced by proteins of the mitochondrial respiratory chain. The levels of ROS are controlled by the activities of mitochondrial redox proteins such as glutaredoxin 2 that help to modulate the susceptibility...
Articles
Biochem Soc Trans (2013) 41 (2): 657–663.
Published: 21 March 2013
...Colin R. Lenihan; Cormac T. Taylor Hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial...
Articles
Biochem Soc Trans (2011) 39 (5): 1376–1381.
Published: 21 September 2011
... apoptosis in endothelial cells. These findings provide a novel mechanism by which ADI inhibits tumour angiogenesis through modulating endothelial tip cells. 1 To whom correspondence should be addressed (email yluo@tsinghua.edu.cn ). 18 6 2011 © The Authors Journal compilation © 2011...
Includes: Supplementary data
Articles
Biochem Soc Trans (2011) 39 (5): 1461–1465.
Published: 21 September 2011
... proliferation, virus replication and cell death. In this paper, we will review the newest findings in this field. 1 To whom correspondence should be addressed (email Cristina.mazzoni@uniroma1.it ). 10 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 apoptosis...
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Biochem Soc Trans (2011) 39 (5): 1527–1532.
Published: 21 September 2011
... are antimicrobial peptides. In the present review, we provide an overview of antifungal peptides isolated from plants, insects, amphibians and mammals that induce apoptosis. Their antifungal spectrum, mode of action and toxicity are discussed in more detail. 1 To whom correspondence should be addressed...
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Biochem Soc Trans (2011) 39 (5): 1499–1501.
Published: 21 September 2011
...Birthe Fahrenkrog The baker's yeast, Saccharomyces cerevisiae , is also capable of undergoing programmed cell death or apoptosis, for example in response to viral infection as well as during chronological and replicative aging. Intrinsically, programmed cell death in yeast can be induced...
Articles
Biochem Soc Trans (2011) 39 (5): 1502–1508.
Published: 21 September 2011
...@exeter.ac.uk ). 17 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 apoptosis caspase necrosis programmed cell death (PCD) protease Saccharomyces cerevisiae Understanding the molecular mechanisms regulating and executing PCD (programmed cell death...
Articles
Biochem Soc Trans (2011) 39 (4): 1102–1106.
Published: 20 July 2011
... species) can be produced under the stimulus of different cytokines such as TNFα (tumour necrosis factor α). It has been shown in different experimental models that they are also able to regulate apoptosis and other cellular processes. The status of oxidative stress elements in Crohn's disease...
Articles
Biochem Soc Trans (2011) 39 (1): 349–354.
Published: 19 January 2011
... of the infected cells. The present article focuses on possible underlying mechanisms for glycosylation changes in the uroepithelial cell receptors for FimH. Like diabetes, bacterial adhesion induces apoptosis that may bring the endoplasmic reticulum membrane with immature mannosylated glycoproteins to the surface...
Articles
Biochem Soc Trans (2010) 38 (6): 1571–1575.
Published: 24 November 2010
... and resistance to apoptosis in the common human disease, chronic lymphocytic leukaemia. miRNA-based therapeutic approaches to treat cancer are emerging. Bcl2 is highly regulated by miRNAs and is therefore an excellent candidate for such approaches. 1 To whom correspondence should be addressed (email...
Articles
Biochem Soc Trans (2009) 37 (1): 200–203.
Published: 20 January 2009
...Anne-Laure Mahul-Mellier; Flavie Strappazzon; Christine Chatellard-Causse; Béatrice Blot; David Béal; Sakina Torch; Fiona Hemming; Anne Petiot; Jean-Marc Verna; Sandrine Fraboulet; Rémy Sadoul Alix [ALG-2 (apoptosis-linked gene 2)-interacting protein X] is a ubiquitinous adaptor protein first...
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Biochem Soc Trans (2009) 37 (1): 137–142.
Published: 20 January 2009
.... 1 To whom correspondence should be addressed (email stenmark@ulrik.uio.no ). 17 7 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 apoptosis endosomal sorting complex required for transport (ESCRT) growth factor receptor Notch tumour suppressor...
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Biochem Soc Trans (2008) 36 (6): 1472–1477.
Published: 19 November 2008
... physiological and cellular functions that are regulated by galectin–glycoprotein interactions. 1 To whom correspondence should be addressed (email lbaum@mednet.ucla.edu ). 10 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 apoptosis endocytosis galectin...
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Biochem Soc Trans (2008) 36 (5): 959–962.
Published: 19 September 2008
... regulation of this pathway may be involved in mediating their effects on viability. 1 To whom correspondence should be addressed (email noel.morgan@pms.ac.uk ). 21 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 apoptosis eukaryotic initiation factor 2α...
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Biochem Soc Trans (2008) 36 (5): 905–908.
Published: 19 September 2008
...Noel G. Morgan; Shalinee Dhayal; Eleftheria Diakogiannaki; Hannah J. Welters Chronic exposure of pancreatic β-cells to long-chain fatty acids can cause loss of secretory function and enhanced apoptosis by a process of ‘lipotoxicity’, which may be a contributory factor to the rising incidence...
Articles
Biochem Soc Trans (2008) 36 (5): 963–965.
Published: 19 September 2008
...Anath Shalev Glucotoxicity plays a major role in pancreatic β-cell apoptosis and diabetes progression, but the factors involved have remained largely unknown. Our recent studies have identified TXNIP (thioredoxin-interacting protein) as a novel pro-apoptotic β-cell factor that is induced by glucose...
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Biochem Soc Trans (2008) 36 (5): 786–790.
Published: 19 September 2008
... autophagic, or type II) that is characterized by the massive accumulation of autophagosomes. Regulators of apoptosis (e.g. Bcl-2 family members) also modulate autophagy, suggesting an intimate cross-talk between these two degradative pathways. It is still unclear whether autophagic vacuolization has...
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Biochem Soc Trans (2008) 36 (5): 909–915.
Published: 19 September 2008
... 2008 Biochemical Society 2008 apoptosis diabetes endoplasmic reticulum stress (ER stress) insulin lipotoxicity pancreatic β-cell The ER stress response is an important adaptive cellular signalling response in cells with high secretory activity. It aims to balance secretory protein...
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Biochem Soc Trans (2008) 36 (4): 629–631.
Published: 22 July 2008
... in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult...
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Biochem Soc Trans (2008) 36 (3): 334–339.
Published: 21 May 2008
... and TNFα mediate activation of the transcription factor NF-κB (nuclear factor κB) pathway. Use of a degradation-resistant NF-κB protein inhibitor (ΔNIκBα), specifically expressed in β-cells, significantly reduced IL-1β+IFN-γ-induced apoptosis. Moreover, in vivo , it protected against multiple low-dose...
Articles
Biochem Soc Trans (2008) 36 (3): 340–342.
Published: 21 May 2008
... apoptosis β-cell death cytokine islet inflammation macrophage Type 2 diabetes In this review, we present evidence for the presence of islet inflammation in patients with Type 2 diabetes. Indeed, the pathology of the islet in this condition is characterized by the presence of immune cell...