...+ release function, leading to triggered arrhythmias that may cause SCD (sudden cardiac death). Resolving the precise molecular mechanisms by which SCD-linked RyR2 dysfunction occurs currently constitutes a burgeoning area of cardiac research. So far, defective channel phosphorylation, accessory protein...

... also been implicated in the generation of arrhythmias in the common condition of HF (heart failure). We have prepared cardiac RyR2 plasmids with various CPVT mutations to enable expression and analysis of Ca 2+ release mediated by the wild-type and mutated RyR2. These studies suggest...

... is to start with genes, make proteins from them and to try to build things bottom-up.’ What did he mean? 1 email denis.noble@physiol.ox.ac.uk 17 1 2005 © 2005 The Biochemical Society 2005 arrhythmia electrocardiogram heart in silico screening LQT3 systems biology...