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Keywords: aspartic proteinase
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 571–573.
Published: 22 May 2007
...C. Dingwall The amyloidogenic processing pathway of the APP (amyloid precursor protein) generates Aβ (amyloid β-peptide), the major constituent in Alzheimer's disease senile plaques. This processing is catalysed by two unusual membrane-localized aspartic proteinases, β-secretase [BACE1 (β-site APP...
