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Keywords: asthma
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Biochem Soc Trans (2020) 48 (5): 2347–2357.
Published: 20 October 2020
... ) 12 8 2020 21 9 2020 22 9 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 asthma chronic obstructive pulmonary disease cilia cystic fibrosis mucus Xenopus As we breathe, we inhale particles, toxins...
Biochem Soc Trans (2009) 37 (4): 886–891.
Published: 22 July 2009
... the disappointing results from recent asthma trials, iNOS inhibition could still be of therapeutic utility in COPD, a concept which needs to be challenged and validated in human disease. Nitric oxide (NO), a gaseous free radical, is a key physiological mediator of pulmonary function, and excessive NO synthesis...
Biochem Soc Trans (2009) 37 (4): 805–810.
Published: 22 July 2009
... contribute to vascular remodelling in lungs after injury or inflammation. Vascular remodelling in the airway is a long recognized component in asthma. Growing numbers of reports suggest that a pro-angiogenic milieu is not a consequence of, but rather dictates the chronic inflammation of asthma. The fairly...
Biochem Soc Trans (2009) 37 (4): 873–876.
Published: 22 July 2009
.... IFNγ interferon γ IL interleukin IL-13R (etc.) IL-13 receptor (etc.) IL-13Rα IL-13 α-chain JAK Janus kinase; MMP, matrix metalloproteinase STAT signal transducer and activator of transcription TGFβ transforming growth factor-β A.-L.A. is an Asthma UK...
Biochem Soc Trans (2009) 37 (4): 824–829.
Published: 22 July 2009
...Ian M. Adcock; Pai-Chien Chou; Andrew Durham; Paul Ford Most of the patients with asthma are found to be successfully treated with conventional therapy. However, there are a small proportion of asthmatic patients who fail to respond to corticosteroids even at high doses or with supplementary...
Biochem Soc Trans (2007) 35 (5): 1104–1108.
Published: 25 October 2007
... of leucocytes, the release of a plethora of inflammatory mediators, activation in cells of the adaptive immune response and the ability to migrate and undergo chemotaxis. Chronic asthma is a disease characterized by a mixed inflammatory cell pulmonary infiltrate, AHR (airways hyper-responsiveness) and tissue...
Biochem Soc Trans (2006) 34 (4): 594–599.
Published: 21 July 2006
... such as immune cells, smooth muscle and epithelial cells. In allergic asthma, airway inflammation, airway obstruction, AHR (airway hyperresponsiveness) and airway remodelling are characteristic features, indicating an intensive interaction between neuronal, structural and immune cells in the lung. In allergic...
Biochem Soc Trans (2004) 32 (2): 378–382.
Published: 01 April 2004
...P.M. Finan; M.J. Thomas Asthma and COPD (chronic obstructive pulmonary disease) are a growing major health burden, which, despite improvements in disease management, still require new effective treatments. As our understanding of the cellular and molecular processes which govern respiratory...
Biochem Soc Trans (2003) 31 (1): 60–65.
Published: 01 February 2003
...M. Kagoshima; K. Ito; B. Cosio; I.M. Adcock Corticosteroids are by far the most effective treatment for chronic inflammatory diseases such as asthma. Inflammation in asthma is characterized by the increased expression of multiple inflammatory genes, including those that encode cytokines, chemokines...