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Keywords: atherosclerosis
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1673–1682.
Published: 23 November 2022
...Heather M. Wilson Atherosclerosis is a chronic inflammatory disease characterized by lipid accumulation and plaque formation in arterial vessel walls. Atherosclerotic plaques narrow the arterial lumen to increase the risk of heart attacks, ischemic stroke and peripheral vascular disease, which...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 21–32.
Published: 22 February 2022
... 1 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 atherosclerosis extracellular trap histones immunology inflammation macrophages Extracellular traps (ETs) were first discovered by Brinkmann et al. [ 1 ] who found...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2273–2281.
Published: 01 September 2020
...Klaus Ley Atherosclerosis, the pathology underlying heart attacks, strokes and peripheral artery disease, is a chronic inflammatory disease of the artery wall initiated by elevated low-density lipoprotein (LDL) cholesterol levels. LDL accumulates in the artery wall, where it can become oxidized...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (4): 999–1006.
Published: 14 July 2017
... tetraspanin revealed a cholesterol-binding site, which provides a strong link to the pathophysiological condition of atherosclerosis. Dysregulation of the inflammatory cascade in autoimmune diseases by endothelial cells is exemplified by the involvement of tetraspanins in multiple sclerosis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1006–1011.
Published: 11 August 2014
... thrombosis and impair fibrinolysis, accelerate the development of atherosclerosis, increase the extent of myocardial ischaemia, and increase susceptibility to myocardial infarction. The pathways underlying these effects are complex and poorly understood; however, particulate-induced oxidative stress...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 443–449.
Published: 20 March 2014
... activity, as recent studies have elucidated that AGEs and their major precursor, MG (methylglyoxal), may have an important role in the progression of atherosclerosis and plaque rupture. MG can be detoxified by Glo1 (glyoxalase I), thereby preventing the accumulation of MG and MG-derived AGEs...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 528–533.
Published: 20 March 2014
... atherosclerosis, as indicated by peripheral artery disease (A.S. Peters, M. Hakimi, T. Fleming, P. Nawroth, D. Böckler and S. Dihlmann, unpublished work). Glo1 activity in carotid lesions is not associated with diabetes mellitus in our study, indicating that it is an independent prognostic factor for progression...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 244–249.
Published: 20 March 2014
... of inflammation-driven diseases, including atherosclerosis. In the present paper, I review our current understanding of TGR5 with a strong focus on its potential as target for intervention in inflammation-driven diseases. TGR5 is expressed in specific cells and tissues at different expression levels, e.g...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 129–132.
Published: 19 January 2012
... compilation © 2012 Biochemical Society 2012 atherosclerosis cancer embryonic development reactive oxygen species (ROS) Podosomes and invadopodia can be defined as dynamic actin-rich protrusions of the ventral membrane of certain cell types [ 1 ]. They are the sites of attachment...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1649–1653.
Published: 21 November 2011
...Nadine Suffee; Benjamin Richard; Hanna Hlawaty; Olivier Oudar; Nathalie Charnaux; Angela Sutton Atherosclerosis is an inflammatory disease that is one of the leading causes of death in developed countries. This disease is defined by the formation of an atherosclerotic plaque, which is responsible...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (6): 1453–1455.
Published: 23 November 2007
...P.S. Tobias; L.K. Curtiss At one time, atherosclerosis was thought to be a simple lipid storage disease. However, it is now recognized as a chronic and progressive inflammation of the arterial wall. Gene deletion experiments in murine models of atherosclerosis that reduce the inflammatory process...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1163–1165.
Published: 25 October 2007
... 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 atherosclerosis chemokine interleukin neutrophil stroke systemic inflammation Most stroke patients present with co-morbidities, such as atherosclerosis, hypertension, diabetes or infection, all...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 857–861.
Published: 25 October 2007
..., the mast cells may contribute to the onset of acute atherothrombotic complications of coronary atherosclerosis, such as myocardial infarction. 1 Owing to exceptional unforeseen circumstances, this speaker was unable to give this presentation at the meeting. This paper is included in the interest...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 887–889.
Published: 25 October 2007
...C.L. Jackson Little is known of the relationship between plaque rupture and adaptive geometric remodelling, especially in the context of unstable atherosclerosis. We have assessed remodelling in the proximal brachiocephalic arteries of fat-fed apoE (apolipoprotein E)-knockout mice. The rate...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 895–899.
Published: 25 October 2007
... email qingbo.xu@kcl.ac.uk 18 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 atherosclerosis endothelium progenitor cell smooth muscle cell stem cell vein graft remodelling Stem cells have the capability to transform and replenish the different...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 451–453.
Published: 22 May 2007
...K.G. Jackson; C.K. Armah; A.M. Minihane With increasing recognition of the pivotal role of vascular dysfunction in the progression of atherosclerosis, the vasculature has emerged as an important target for dietary therapies. Recent studies have indicated that chronic fatty acid manipulation alters...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 464–465.
Published: 22 May 2007
...C. Bentley; F. Bejta; C. De Pascale; M. Avella; C.P.D. Wheeler-Jones; K.M. Botham; C. Lawson In early atherosclerosis the frequency of activated monocytes in the peripheral circulation is amplified, and migration of monocytes into the walls of the aorta and large arteries is increased, due partly...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 437–439.
Published: 22 May 2007
...K.M. Botham; C.P.D. Wheeler-Jones Although it has been known for many years that dietary lipids influence the development of atherosclerosis, in the past this has been attributed to their effects on blood cholesterol levels. Recent work, however, has shown that CMRs (chylomicron remnants...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 454–458.
Published: 22 May 2007
...K.M. Botham; E.H. Moore; C. De Pascale; F. Bejta The accumulation of foam cells in the artery wall causes fatty streaks, the first lesions in atherosclerosis. LDL (low-density lipoprotein) plays a major role in foam cell formation, although prior oxidation of the particles is required. Recent...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 477–481.
Published: 22 May 2007
... that biglycan protein core content increases with age and is exacerbated by IR, supporting the theory that vascular dysfunction associated with IR can remodel extracellular proteoglycans ( Figure 1 ). The insights gained from these studies will help elucidate our understanding of atherosclerosis, obesity...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1141–1144.
Published: 25 October 2006
...D.P. Ramji; N.N. Singh; P. Foka; S.A. Irvine; K. Arnaoutakis The regulation of macrophage cholesterol homoeostasis is of crucial importance in the pathogenesis of atherosclerosis, an underlying cause of heart attack and stroke. Several recent studies have revealed a critical role for the cytokine...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 79–82.
Published: 01 February 2004
... in clearance of chylomicron remnants is probably an indication of a more generalized defect in lipoprotein metabolism. Accumulating evidence supports a relationship between abnormalities in the clearance from plasma of chylomicron remnants and accelerated progression of atherosclerosis. Methods using stable...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 116–120.
Published: 01 February 2004
..., and in macrophages in atherosclerotic plaques. The physiological role of SR-BI has been tested in vivo by the genetic manipulation of SR-BI levels in mice. Mice lacking SR-BI exhibit impaired hepatic-selective HDL cholesterol uptake and increased atherosclerosis, suggesting that SR-BI is required for hepatic reverse...
Articles
S.L. Parkin, J.P. Pritchett, D.C. Grimsditch, K.R. Bruckdorfer, P.K. Sahota, A. Lloyd, P. Overend, G.M. Benson
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 128–130.
Published: 01 February 2004
...S.L. Parkin; J.P. Pritchett; D.C. Grimsditch; K.R. Bruckdorfer; P.K. Sahota; A. Lloyd; P. Overend; G.M. Benson We have investigated serum chemokines for their suitability as markers of atherosclerosis development in apoE (apolipoprotein E)-deficient ( −/− ) mice. Female C3H apoE −/− and C57BL apoE...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 134–138.
Published: 01 February 2004
...W. Jessup; L. Kritharides; R. Stocker The ‘oxidation theory’ for atherosclerosis proposes that lipid and/or protein oxidation products are responsible for lesion formation/development. The major target for oxidation is suggested to be intimal low-density lipoprotein. This idea was stimulated...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 156–159.
Published: 01 February 2004
... by non-radical mechanisms. 1 e-mail etsuo-niki@aist.go.jp 44th International Conference on the Bioscience of Lipids, a meeting held at Keble College, Oxford, 7–11 September 2003 7 September 2003 © 2004 Biochemical Society 2004 antioxidant atherosclerosis free radical...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 1066–1069.
Published: 01 October 2003
...C.J. Packard LDL (low-density lipoprotein) is the major carrier of cholesterol in human plasma, and as such is intimately involved in the process of atherosclerosis. The lipoprotein class comprises a number of distinct subfractions, and is commonly divided into large, intermediate and small sized...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 1075–1079.
Published: 01 October 2003
...S. Toomey; H. Roche; D. Fitzgerald; O. Belton Conjugated linoleic acid (CLA) refers to a group of positional and geometric isomers of linoleic acid that has been shown to suppress the development of atherosclerosis in a rabbit model. We investigated whether CLA acts as a cyclo-oxygenase (COX...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 1080–1084.
Published: 01 October 2003
...P. Cullen The link between raised levels of LDL (low-density lipoprotein) cholesterol in the blood and atherosclerosis is incontrovertible. The situation with regard to TRLs (triacylglycerol-rich lipoproteins) is not as clear. Nevertheless, there is substantial evidence that TRLs may in some cases...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 1090–1093.
Published: 01 October 2003
...M. Castro Cabezas FCHL (familial combined hyperlipidaemia) is the most frequent inherited disorder of lipid metabolism leading to premature atherosclerosis. The usual phenotype in FCHL is elevated fasting plasma triacylglycerols, low HDL (high-density lipoprotein)-cholesterol concentrations...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (3): 528–531.
Published: 01 June 2003
..., a Biochemical Society Focused Meeting held at St. Andrews University, 12–14 January 2003 18 December 2002 © 2003 Biochemical Society 2003 atherosclerosis cholesterol-lowering enzyme inhibition isothermal titration calorimetry statin X-ray crystallography Abbreviations used...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (2): 429–432.
Published: 01 April 2003
... for treatment of atherosclerosis. 1 To whom correspondence should be addressed (e-mail marcel.vanduin@organon.com ). 678th Meeting of the Biochemical Society, held at Imperial College, London, 16–18 December 2002 20 November 2002 Copyright 2003 Biochemical Society 2003...
Articles
N.B. Ruderman, J.M. Cacicedo, S. Itani, N. Yagihashi, A.K. Saha, J.M. Ye, K. Chen, M. Zou, D. Carling, G. Boden, R.A. Cohen, J. Keaney, E.W. Kraegen, Y. Ido
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (1): 202–206.
Published: 01 February 2003
... 2003 Biochemical Society 2003 acetyl-CoA carboxylase Akt atherosclerosis diacylglycerol fatty acid oxidation fuel sensing oxidative stress protein kinase C tumour necrosis factor α Abbreviations used: ACC, acetyl-CoA carboxylase; AICAR, 5-amino-4-imidazolecarboxamide riboside...
