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Keywords: autism
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Articles

Neurodevelopmental functions of CHD8: new insights and questions

M. Albert Basson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 15–27.
https://doi.org/10.1042/BST20220926
Published: 30 January 2024
...M. Albert Basson Heterozygous, de novo , loss-of-function variants of the CHD8 gene are associated with a high penetrance of autism and other neurodevelopmental phenotypes. Identifying the neurodevelopmental functions of high-confidence autism risk genes like CHD8 may improve our understanding...
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Articles

Mutation of genes controlling mRNA metabolism and protein synthesis predisposes to neurodevelopmental disorders

Francesca Sartor, Jihan Anderson, Colin McCaig, Zosia Miedzybrodzka, Berndt Müller
Journal: Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (6): 1259–1265.
https://doi.org/10.1042/BST20150168
Published: 27 November 2015
... 2015 © 2015 Authors; published by Portland Press Limited 2015 autism intellectual disability messenger ribonucleic acid (mRNA) export nonsense-mediated messenger ribonucleic acid (mRNA) decay splicing translation initiation Brain development is a complex and delicate process...
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