... HGF/MET signaling is a driver of many cancers and contributes to drug resistance to several approved therapeutics targeting other RTKs, making MET itself an important drug target. In RTKs, homeostatic receptor signaling is dependent on autoinhibition in the absence of ligand binding and orchestrated...

... 82 4898 4907 28 Zamborlini A. Usami Y. Radoshitzky S.R. Popova E. Palu G. Gottlinger H. Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding Proc. Natl. Acad. Sci. U.S.A. 2006 103 19140 19145 29 Shim S...

...; the resultant domain mobility leads to activation. autoinhibition calmodulin cytochrome c electron transfer nitric oxide reductase domain Abbreviations used: NOS, nitric oxide synthase; nNOS, iNOS, eNOS, neuronal, induced and endothelial NOS respectively; nNOSrd, nNOS reductase domain...