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Keywords: autophagy
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Articles
Biochem Soc Trans (2021) BST20190236.
Published: 26 March 2021
... this disease. In recent years, defective mitochondrial elimination through autophagy, termed mitophagy, has emerged as a potential contributing factor to disease pathology. PINK1 and Parkin, two proteins mutated in familial PD, were found to eliminate mitochondria under distinct mitochondrial...
Articles
Biochem Soc Trans (2020) 48 (5): 2003–2014.
Published: 08 September 2020
...Jahangir Md. Alam; Nobuo N. Noda Autophagy is a lysosomal degradation system that involves de novo autophagosome formation. A lot of factors are involved in autophagosome formation, including dozens of Atg proteins that form supramolecular complexes, membrane structures including vesicles and...
Articles
Biochem Soc Trans (2020) 48 (4): 1599–1607.
Published: 14 July 2020
...Syn Kok Yeo; Chenran Wang; Jun-Lin Guan FIP200 (RB1CC1) is a critical regulator of canonical macroautophagy and has also emerged as a crucial regulator of selective autophagy as well as inflammatory processes. The illumination of FIP200's role in autophagy at the molecular level has been...
Articles
Biochem Soc Trans (2019) 47 (4): 1173–1185.
Published: 05 August 2019
... © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 autophagy lysosomes membrane contact sites nutrient signaling phosphosinositides Lysosomes have long been regarded solely as a degradative compartment in eukaryotic cells. However, in...
Articles
Biochem Soc Trans (2018) 46 (4): 877–889.
Published: 19 July 2018
... triggering of NPC quality control mechanisms can lead to herniations in budding yeast, which are remarkably similar to those observed in human disease models of early-onset dystonia. By also examining the provenance of nuclear envelope herniations associated with emerging nuclear autophagy and nuclear egress...
Articles
Biochem Soc Trans (2018) 46 (1): 97–110.
Published: 05 January 2018
...Kevin C. Yang; Paalini Sathiyaseelan; Cally Ho; Sharon M. Gorski Autophagy is an evolutionarily conserved lysosome-mediated degradation and recycling process, which functions in cellular homeostasis and stress adaptation. The process is highly dynamic and involves autophagosome synthesis, cargo...
Articles
Biochem Soc Trans (2017) 45 (6): 1323–1331.
Published: 17 November 2017
... article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . autophagy endoplasmic reticulum trafficking Autophagy is an intracellular degradation process that contributes to cellular...
Articles
Biochem Soc Trans (2017) 45 (1): 155–162.
Published: 15 February 2017
..., therefore, controlling a plethora of diverse functions based on the different complexes formed. Among these, I will then focus on macroautophagy in the general context of the endolysosomal system. First, the relevance of autophagy in Parkinson's disease will be evaluated giving a brief overview of all the...
Articles
Biochem Soc Trans (2016) 44 (6): 1603–1610.
Published: 02 December 2016
... several recent studies have suggested that the Rab family of small GTPases might be important in controlling the recruitment of LRRK2 to specific cellular compartments. Once localized to membranes, LRRK2 then influences downstream events, evidenced by changes in the autophagy–lysosome pathway. Here, I...
Articles
Biochem Soc Trans (2016) 44 (2): 431–440.
Published: 11 April 2016
... homoeostasis imbalance, the dynamics of peroxisomes have been widely examined. The increasing volume of reports demonstrating significant involvement of the autophagy machinery in peroxisome removal leads us to summarize current knowledge of peroxisome degradation in mammalian cells. In this review we present...
Articles
Biochem Soc Trans (2016) 44 (2): 541–545.
Published: 11 April 2016
... that is coupled to mitochondrial dynamics on the one hand, and mitophagic engulfment on the other [ 45 ]. Interestingly, Mao et al reported a direct interaction between Atg11, an autophagy factor that functions in cargo selectivity, and Dnm1, a dynamin like FTPase required for mitochondrial fission...
Articles
Biochem Soc Trans (2015) 43 (5): 1122–1126.
Published: 09 October 2015
... models of cancer autophagy cannabinoids endoplasmic reticulum (ER) stress tribbles pseudokinases Pseudokinases are a sub-type of protein kinases lacking at least one of the conserved catalytic residues present in their kinase domain. As a consequence, these proteins exhibit very low levels of...
Articles
Biochem Soc Trans (2015) 43 (4): 543–552.
Published: 03 August 2015
... autophagy. This review focuses on the current understanding of this pathway and focuses on the interplay with reactive oxygen species (ROS) and the voltage-dependent anion channel (VDAC), to which TSPO binds, in the regulation of cell mitophagy and hence homoeostasis of the mitochondrial network as a whole...
Articles
Biochem Soc Trans (2015) 43 (3): 471–475.
Published: 01 June 2015
... Society 2015 autophagy connexin 43 endocytosis gap junction ubiquitin Gap junctions (GJs) are intercellular channels, formed by six subunits of a transmembrane protein called connexin (Cx) that mediate the direct communication between the cytoplasm of adjacent cells. Gap junction...
Articles
Biochem Soc Trans (2015) 43 (3): 390–395.
Published: 01 June 2015
... © 2015 Biochemical Society 2015 autophagy endocytosis leucine-rich repeat kinase 2 (LRRK2) nicotinic acid adenine dinucleotide phosphate (NAADP) Parkinson's disease Rab protein Parkinson's disease (PD) is a prominent neurodegenerative disorder without a cure. Mutations in leucine-rich...
Articles
Biochem Soc Trans (2015) 43 (3): 476–481.
Published: 01 June 2015
... junctions (GJ). Cardiomyocytes are the major cell population in the heart, and as cells with low mitotic activity, are highly dependent upon mechanisms of protein degradation. In the heart, both the ubiquitin-proteasome system (UPS) and autophagy participate in the fine-tune regulation of cardiac...
Articles
Biochem Soc Trans (2015) 43 (2): 229–234.
Published: 07 April 2015
... survival, differentiation and now autophagy. Herein, we describe how myristoylation may play a role in autophagy with an emphasis on PTMyr. 1 To whom correspondence should be addressed (email dalem@cmmt.ubc.ca ). 16 10 2014 © The Authors Journal compilation © 2015 Biochemical Society...
Articles
Biochem Soc Trans (2014) 42 (5): 1389–1395.
Published: 18 September 2014
... gaps in our knowledge that need additional work. 1 To whom correspondence should be addressed (email nicholas.ktistakis@babraham.ac.uk ) . 2 7 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 autophagy mammalian (or mechanistic) target of rapamycin...
Articles
Biochem Soc Trans (2014) 42 (5): 1327–1334.
Published: 18 September 2014
...Michael I. Wilson; Hannah C. Dooley; Sharon A. Tooze The double-membraned autophagosome organelle is an integral part of autophagy, a process that recycles cellular components by non-selectively engulfing and delivering them to lysosomes where they are digested. Release of metabolites from this...
Includes: Supplementary data
Articles
Biochem Soc Trans (2014) 42 (5): 1414–1417.
Published: 18 September 2014
...Simon G. Pfisterer; Daniela Bakula; Alice Cezanne; Horst Robenek; Tassula Proikas-Cezanne Macroautophagy (autophagy hereafter) is an evolutionarily highly conserved catabolic process activated by eukaryotes in order to counteract cellular starvation. Autophagy leads to bulk degradation of...
Articles
Biochem Soc Trans (2013) 41 (6): 1503–1508.
Published: 20 November 2013
... (α-synuclein) multiplication and idiopathic PD. In some cases, isogenic control lines have been created to minimize inherent variability between lines from different individuals. Disruptions in autophagy, mitochondrial function and dopamine biology at the synapse have been described. Future...
Articles
Biochem Soc Trans (2013) 41 (6): 1598–1604.
Published: 20 November 2013
.... When we compared the potential mutSOD1 toxicity in motoneuron (NSC34) and muscle (C2C12) cells, we found that muscle ALS models possess much higher chymotryptic proteasome activity and autophagy power than motoneuron ALS models. As a result, mutSOD1 molecular behaviour was found to be very different...
Articles
Biochem Soc Trans (2013) 41 (6): 1483–1488.
Published: 20 November 2013
... failure to function properly contributes to pathogenesis and disease progression. In the present mini-review, we describe this dual role as ‘saviour’ and ‘victim’ in the context of neurodegeneration for chaperone-mediated autophagy, a cellular pathway involved in the selective degradation of cytosolic...
Articles
Biochem Soc Trans (2013) 41 (6): 1489–1494.
Published: 20 November 2013
...Xiaoting Wu; Hyeran Won; David C. Rubinsztein Autophagy is a highly conserved cytoplasmic degradation pathway that has an impact on many physiological and disease states, including immunity, tumorigenesis and neurodegeneration. Recent studies suggest that autophagy may also have important functions...
Articles
Biochem Soc Trans (2013) 41 (5): 1103–1130.
Published: 23 September 2013
...Sovan Sarkar Autophagy is an intracellular degradation pathway essential for cellular and energy homoeostasis. It functions in the clearance of misfolded proteins and damaged organelles, as well as recycling of cytosolic components during starvation to compensate for nutrient deprivation. This...
Articles
Biochem Soc Trans (2013) 41 (4): 962–967.
Published: 18 July 2013
...Daniela Bakula; Zsuzsanna Takacs; Tassula Proikas-Cezanne Autophagy is a catabolic pathway in which the cell sequesters cytoplasmic material, including long-lived proteins, lipids and organelles, in specialized double-membrane vesicles, called autophagosomes. Subsequently, autophagosomes...
Articles
Biochem Soc Trans (2013) 41 (4): 939–943.
Published: 18 July 2013
... cell and appropriately dictates whether the cell will actively favour energy- and amino-acid-consuming anabolic processes such as cellular growth, or energy- and amino-acid-generating catabolic processes such as autophagy. The present review discusses important feedback mechanisms between these three...
Articles
Biochem Soc Trans (2012) 40 (6): 1368–1372.
Published: 21 November 2012
... consider possible hypotheses in order to explain how alterations of Rab7 function lead to CMT2B. 1 To whom correspondence should be addressed (email cecilia.bucci@unisalento.it ). 2 8 2012 © 2012 The Authors Journal 2012 autophagy Charcot–Marie–Tooth disease endocytosis...
Articles
Biochem Soc Trans (2012) 40 (5): 1147–1151.
Published: 19 September 2012
... LRRK2 and autophagy. Implications of this set of data for our understanding of LRRK2′s role in physiology and disease are discussed in the present paper. 1 email c.manzoni@ucl.ac.uk 2 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 autophagy...
Articles
Biochem Soc Trans (2012) 40 (5): 1080–1085.
Published: 19 September 2012
.... 1 To whom correspondence should be addressed (email javier.alegre@dpag.ox.ac.uk ). 25 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 autophagy cytoskeleton dopamine leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease tau Mutations in...
Articles
Biochem Soc Trans (2012) 40 (5): 1129–1133.
Published: 19 September 2012
... autophagy regulation. Autophagy is an intracellular catabolic mechanism whereby a cell recycles or degrades damaged proteins and cytoplasmic organelles. In the present paper, we discuss the role of LRRK2 in autophagy, and the importance of this relationship in the development of nigral degeneration in PD...
Articles
Biochem Soc Trans (2012) 40 (5): 1042–1046.
Published: 19 September 2012
... as well as impaired dopamine D 2 receptor-mediated functions. Whereas LRRK2 −/− brains are normal, LRRK2 −/− kidneys at 20 months of age develop striking accumulation and aggregation of α-synuclein and ubiquitinated proteins, impairment of the autophagy–lysosomal pathway, and increases in apoptotic...
Articles
Biochem Soc Trans (2012) 40 (5): 1070–1073.
Published: 19 September 2012
... is needed to understand them in more depth. 1 email cookson@mail.nih.gov 29 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 autophagy cell death inclusion body leucine-rich repeat kinase 2 (LRRK2) neurite Parkinson's disease The...
Articles
Biochem Soc Trans (2012) 40 (5): 1052–1057.
Published: 19 September 2012
...@weizmann.ac.il ). 19 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 autophagy autophosphorylation DAPK (death-associated protein kinase) leucine-rich repeat kinase 2 (LRRK2) The ROCO proteins are defined by predicted sequence similarity within two domains...
Articles
Biochem Soc Trans (2012) 40 (4): 656–660.
Published: 20 July 2012
... the effects on autophagy pathways. MSUT2 represents a potential drug target for prevention of tau-related neurodegeneration. 1 To whom correspondence should be addressed (email kraemerb@u.washington.edu ). 12 3 2012 © The Authors Journal compilation © 2012 Biochemical Society...
Articles
Biochem Soc Trans (2012) 40 (4): 644–652.
Published: 20 July 2012
... UPS (ubiquitin–proteasome system) and the ALS (autophagy–lysosome system). In the present paper, we focus on the regulation of the degradation of tau by the UPS and ALS and its relation to tau aggregation. We anticipate that stimulation of these two protein-degradation systems might be a potential...
Articles
Biochem Soc Trans (2012) 40 (1): 37–43.
Published: 19 January 2012
...Nicholas T. Ktistakis; Maria Manifava; Priya Schoenfelder; Sergio Rotondo The simple phosphoinositide PtdIns3 P has been shown to control cell growth downstream of amino acid signalling and autophagy downstream of amino acid withdrawal. These opposing effects depend in part on the existence of...
Articles
Biochem Soc Trans (2011) 39 (5): 1466–1470.
Published: 21 September 2011
...Belém Sampaio-Marques; Carolina Felgueiras; Alexandra Silva; Fernando Rodrigues; Paula Ludovico Autophagy, a highly conserved proteolytic mechanism of quality control, is essential for the maintenance of metabolic and cellular homoeostasis and for an efficient cellular response to stress. Autophagy...
Articles
Biochem Soc Trans (2011) 39 (5): 1514–1519.
Published: 21 September 2011
...Matthias Müller; Andreas S. Reichert Autophagy is a fundamental cellular process promoting survival under various environmental stress conditions. Selective types of autophagy have gained much interest recently as they are involved in specific quality control mechanisms removing, for example...
Articles
Biochem Soc Trans (2011) 39 (4): 1067–1072.
Published: 20 July 2011
... compilation © 2011 Biochemical Society 2011 autophagy Crohn's disease dysbiosis microbiota ulcerative colitis UC (ulcerative colitis) and Crohn's disease are the two predominant phenotypes of IBD (inflammatory bowel disease). Crohn's disease can cause transmural inflammation, affect any part...
Articles
Biochem Soc Trans (2011) 39 (2): 460–465.
Published: 22 March 2011
... pharmacological inhibitor of the TOR pathway, rapamycin, can replicate those findings and improve aging in a variety of model organisms. The proposed underlying anti-aging mechanisms are down-regulated translation, increased autophagy, altered metabolism and increased stress resistance. 1 Correspondence...
Articles
Biochem Soc Trans (2010) 38 (6): 1436–1441.
Published: 24 November 2010
... addressed (email steve.walkley@einstein.yu.edu ). 26 4 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 autophagy axonal spheroid axoplasmic transport lysosomal disease Niemann–Pick type C disease Purkinje cell Lysosomal diseases were first described...
Articles
Biochem Soc Trans (2010) 38 (6): 1442–1447.
Published: 24 November 2010
... pathway. 1 To whom correspondence should be addressed (email jmheard@pasteur.fr ). 26 4 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 autophagy Golgi matrix protein 130 (GM130) lysosomal storage disease (LSD) lysosome-associated membrane protein...
Articles
Biochem Soc Trans (2010) 38 (6): 1420–1423.
Published: 24 November 2010
... To whom correspondence should be addressed (email psaftig@biochem.uni-kiel.de ). 26 8 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 autophagy cholesterol homoeostasis lysosome lysosome membrane protein phagocytosis trafficking The lysosomal...
Articles
Biochem Soc Trans (2010) 38 (1): 144–149.
Published: 19 January 2010
.... In addition to the ubiquitin–proteasome system, the aggresome–autophagy pathway has emerged as another crucial cellular defence system against toxic build-up of misfolded proteins. In contrast with basal autophagy that mediates non-selective, bulk clearance of misfolded proteins along with normal...
Articles
Biochem Soc Trans (2009) 37 (1): 213–216.
Published: 20 January 2009
... autophagy protein kinase mammalian target of rapamycin (mTOR) therapeutic agent The timely ‘mTOR Signalling, Nutrients and Disease’ meeting brought together groups with shared interests in the regulation and effects of mTOR (mammalian target of rapamycin), a highly conserved serine/threonine...
Articles
Biochem Soc Trans (2009) 37 (1): 253–258.
Published: 20 January 2009
...Aimee L. Edinger Ceramide induces differentiation, proliferative arrest, senescence and death in mammalian cells. The mechanism by which ceramide produces these outcomes has proved difficult to define. Building on observations that ceramide stimulates autophagy, we have identified a novel mechanism...
Articles
Biochem Soc Trans (2009) 37 (1): 232–236.
Published: 20 January 2009
... vesicles called autophagosomes. Fusion of these vesicles with the endolysosomal compartment leads to breakdown of the sequestered material into amino acids and other simple molecules, which can be used as nutrient sources during periods of starvation. This process is driven by a group of autophagy-related...
Articles
Biochem Soc Trans (2009) 37 (1): 208–212.
Published: 20 January 2009
.... 1 To whom correspondence should be addressed (email a.isaacs@prion.ucl.ac.uk ). 11 9 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 autophagy charged multivesicular body protein 2B (CHMP2B) endosomal sorting complex required for transport III (ESCRT-III...
Articles
Biochem Soc Trans (2008) 36 (5): 839–842.
Published: 19 September 2008
... alternatives. On the other hand, there is evidence of an alternative, autophagy, a pathway involving the delivery of cytosolic substrates to the lysosome for degradation. 1 To whom correspondence should be addressed (email lanton@cbm.uam.es ). 18 3 2008 © The Authors Journal compilation...