... Journal compilation © 2009 Biochemical Society 2009 anxiety benzodiazepine cognition γ-aminobutyric acid type A receptor (GABA A receptor) pain schizophrenia The term ‘cognition’ has definitions that range from broad to narrow; its usage here is broad and refers to all activities...

... © The Authors Journal compilation © 2009 Biochemical Society 2009 benzodiazepine brain conductance γ-aminobutyric acid subtype A receptor (GABA A R) hippocampal pyramidal neuron long-term potentiation (LTP) The GABA A Rs [GABA (γ-aminobutyric acid) subtype A receptors] belong...

.... Indeed, it made possible the discovery of a novel benzodiazepine site. We use here subunit concatenation to study δ-subunit-containing GABA A receptors. We provide evidence for the formation of different functional subunit arrangements in recombinant α 1 β 3 δ and α 6 β 3 δ receptors. As with all...

... are constructed as pentameric ion channels, with α and β subunits being the minimal requirement, and the incorporation of a γ subunit being necessary for benzodiazepine modulation and synaptic targeting. Insights have been provided by the discovery of several specific assembly signals within different GABA...

... benzodiazepine concatenated subunit γ-aminobutyric acid (GABA) γ-aminobutyric acid type A receptor (GABA A receptor) subunit positioning subunit specificity During the last few years, subunit concatenation has been applied to members of the pentameric ligand-gated ion channel family. Covalently...

... that have unique regional distributions, but little is known about the role played by each subtype. The majority of the receptors contain a γ 2 subunit and are sensitive to modulation by BZs (benzodiazepines), but differ with regard to α and β subunits. Mutagenesis studies combined with molecular modelling...