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1-3 of 3
Keywords: biased signalling
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Articles
The complexity of signalling mediated by the glucagon-like peptide-1 receptor
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 582–588.
Published: 11 April 2016
... and temporal aspects for the control of signalling and how these concepts may influence future drug development. 1 To whom correspondence should be addressed (email [email protected] ). 7 1 2016 © 2016 Authors; published by Portland Press Limited 2016 biased signalling G...
Articles
From biased signalling to polypharmacology: unlocking unique intracellular signalling using pepducins
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 555–561.
Published: 11 April 2016
... receptor conformations that are currently not accessible through orthosteric targeting. This review addresses the emerging concepts in the development of pepducins including the elicitation of biased signalling, pepducin polypharmacology and recent insight into their mechanism of action. 1 To whom...
Articles
Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function
Available to PurchaseCassandra Koole, Kavita Pabreja, Emilia E. Savage, Denise Wootten, Sebastian G.B. Furness, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 172–179.
Published: 29 January 2013
[email protected] ). 24 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 allosteric modulation biased signalling G-protein-coupled receptor glucagon-like peptide-1 receptor glucagon-like peptide-1 probe-dependence Type 2 DM (diabetes mellitus) is a global...
