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Keywords: bile acid
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Biochem Soc Trans (2014) 42 (2): 244–249.
Published: 20 March 2014
...Thijs W.H. Pols TGR5 (Takeda G-protein-coupled receptor 5) [also known as GPBAR1 (G-protein-coupled bile acid receptor 1), M-BAR (membrane-type receptor for bile acids) or GPR131 (G-protein-coupled receptor 131)] is a G-protein-coupled receptor that was discovered as a bile acid receptor. TGR5 has...
Biochem Soc Trans (2010) 38 (2): 348–352.
Published: 22 March 2010
... of squamous cells or through Barrett's metaplasia. Barrett's metaplasia bile acid gastro-oesophageal reflux disease (GORD) oesophagitis The prevailing concept of reflux oesophagitis pathogenesis is essentially a chemical burn model of injury. It is assumed that refluxed gastric acid...
Biochem Soc Trans (2010) 38 (2): 313–319.
Published: 22 March 2010
... metaplasia and can be activated in oesophageal cell cultures by treatment with bile acids. We have investigated the ability of Cdx2 to bring about intestinal transformations in oesophageal epithelium. Our results show that Cdx2 can activate a programme of intestinal gene expression when overexpressed in HET...
Biochem Soc Trans (2010) 38 (2): 337–342.
Published: 22 March 2010
...James Cronin; Lisa Williams; Elizabeth McAdam; Zak Eltahir; Paul Griffiths; John Baxter; Gareth Jenkins Bile acids have been demonstrated, through the use of animal models and clinical association studies, to play a role in neoplastic development in Barrett's metaplasia. How specific bile acids...
Biochem Soc Trans (2004) 32 (1): 92–96.
Published: 01 February 2004
... the activity of LXR by antagonizing the effect of activators of this receptor, thus contributing to cholesterol accumulation in macrophages. Bile acid synthesis, which represents the final step of reverse cholesterol transport, is transcriptionally regulated by several nuclear receptors at the level...
Biochem Soc Trans (2003) 31 (2): 397–406.
Published: 01 April 2003
... efficient DNA condensation and subsequently drug delivery (i.e. with DNA as the drug) can be brought about using novel polyamine conjugates. Taking further advantage of the functionalization of specific steroids (e.g. cholesterol and certain bile acids), we have designed and prepared novel fluorescent...