...Benjamin J. Hardy; Paul Curnow The major energy-producing reactions of biochemistry occur at biological membranes. Computational protein design now provides the opportunity to elucidate the underlying principles of these processes and to construct bioenergetic pathways on our own terms. Here, we...

... yeast, slime mould, and mammals. We will also highlight the similarities and differences in the relationship between these phosphate-rich biomolecules among this group of organisms. bioenergetics inorganic polyphosphate inositol pyrophosphates phosphate homeostasis signalling Figure 1...

..., the rigor of those studies, and the critical knowledge gaps of relationships between APP, Aβ, and mitochondria. Alzheimer's disease amyloid beta amyloid precursor protein bioenergetics γ-secretase mitochondria Amyloid beta (Aβ) plaques are a hallmark pathology of Alzheimer's disease (AD...

... by Portland Press Limited on behalf of the Biochemical Society 2023 bioenergetics central nervous system insulin resistance metabolism neuromodulation type 2 diabetes Insulin is a peptide best known by being produced by β-cells of the pancreatic islets in response to elevated blood glucose...

... that in the downstream tank, otherwise no energy flow occurs. © 2021 The Author(s) 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioenergetics ischaemia-reperfusion...

... sources plays a key role in cellular bioenergetics and has been studied by biochemical and structural methods already for many decades [ 8–11 ]. More recently, electron cryo -microscopy ( cryo -EM) has revealed the structure of fully intact F-type ATP synthases from chloroplasts at high-resolution...

... 2019 8 11 2019 8 11 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 bioenergetics calcium complex I mitochondria reactive oxygen species Introduction Mitochondria are distinguishable from the other numerous...

... Commons Attribution License 4.0 (CC BY) . bioenergetics cardioprotection creatine kinase ischaemia–reperfusion injury The energy requirements of the human heart are exceptionally high, requiring the equivalent of 6 kg ATP (adenosine triphosphate) per day [ 1 ]. This relies...

... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioenergetics cardiac hypertrophy metabolism mitochondrial dysfunction sodium Cardiovascular disease is the leading cause of mortality worldwide with its incidence projected to rise significantly...

...Charles Affourtit; Ben Alberts; Jonathan Barlow; Jane E. Carré; Anthony G. Wynne The canonical model of glucose-stimulated insulin secretion (GSIS) by pancreatic β-cells predicts a glucose-induced rise in the cytosolic ATP/ADP ratio. Such bioenergetic sensitivity to metabolic fuel is unusual...

... in this subclass of enzymes. 1 To whom correspondence should be addressed (email [email protected] ). 8 8 2013 © 2013 The Authors 2013 bioenergetics hydrogen conversion iron–sulfur cluster (Fe–S cluster) oxygen-tolerant hydrogenase protein structural modelling...

... Present address: VIB Department of Structural Biology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. 3 Present address: European Bioinformatics Institute, Cambridge, CB10 1SD, U.K. 12 8 2013 © 2013 The Authors 2013 bioenergetics complex I membrane...

.... Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T Gene 2008 411 69 76 40 Amo T. Brand M.D. Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis...

... a bioenergetic crisis by so severely limiting cellular access to extracellular nutrients that autophagy is insufficient to meet the metabolic demands of the cell. In keeping with this bioenergetic explanation for ceramide toxicity, methyl pyruvate, a membrane-permeable nutrient, protects cells from ceramide...

... within a metabolic network indicates the extent to which the pathway flux is changed in the steady state when changing the activity of this one enzyme. Control analysis of oxidative phospho- Key words: bioenergetics, isolated perfused liver, top-down metabolic control analysis. rylation has been...