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Keyword: biomarker
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Articles
Biochem Soc Trans (2019) 47 (2): 663-670.
Published: 05 March 2019
... 2019 31 1 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 biomarker exosome LRRK2 neurodegeneration Parkinson disease Genome-wide association studies have identified variants in or nearby the leucine-rich repeat...
Articles
Biochem Soc Trans (2015) 43 (5): 1085-1088.
Published: 09 October 2015
... strongly correlates with the progression of melanocyte-derived malignancies suggests TRIB2 as a meaningful biomarker to both diagnose and stage melanoma. In addition, interfering with TRIB2 activity might be a therapeutic strategy for the treatment of several different tumour types. 1 email walink...
Articles
Biochem Soc Trans (2014) 42 (6): 1658-1664.
Published: 17 November 2014
...David M. Favara; Alison H. Banham; Adrian L. Harris Epidermal growth factor, latrophilin and seven-transmembrane domain-containing 1 (ELTD1), an orphan G-protein-coupled receptor (GPCR) belonging to the adhesion GPCR family, has recently been identified as a potential cancer biomarker and a novel...
Articles
Biochem Soc Trans (2014) 42 (6): 1744-1751.
Published: 17 November 2014
... associated with a plethora of clinical conditions, and these proteins therefore have potential utility as biomarkers of disease and/or response to therapeutic intervention. The present article summarizes current knowledge relating to extracellular cell stress proteins as biomarkers of human disease. 1...
Articles
Biochem Soc Trans (2012) 40 (4): 875-879.
Published: 20 July 2012
... endogenous short non-coding single-stranded RNA oligonucleotides that regulate gene expression post-transcriptionally. Quantification of urinary microRNAs offers an alternative approach to the identification of chronic kidney disease biomarkers. 1 To whom correspondence should be addressed (email...
Articles
Biochem Soc Trans (2012) 40 (1): 20-25.
Published: 19 January 2012
... Dortmund, Germany (email Sina.Koch@mpi-dortmund.mpg.de ). 4 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiogenesis anti-VEGF therapy biomarker neuropilin receptor tyrosine kinase (RTK) vascular endothelial growth factor (VEGF) The mammalian...
Articles
Biochem Soc Trans (2011) 39 (1): 365-369.
Published: 19 January 2011
... increasing number of new alcohol biomarkers that are the result of alcohol-induced glycoconjugate metabolic errors have appeared in the literature. Glycoconjugate-related alcohol markers are involved in, or are a product of, altered glycoconjugate metabolism, e.g. CDT (carbohydrate-deficient transferrin), SA...
Articles
Biochem Soc Trans (2011) 39 (1): 370-373.
Published: 19 January 2011
... biomarker β1,6-branched N-linked oligosaccharide glycosylation melanoma N-acetylglucosaminyltransferase V Melanoma ( melanoma malignum ) is one of the most aggressive human tumours and originates from melanocytes that are responsible for the production of melanin. As such cells are found...
Articles
Biochem Soc Trans (2011) 39 (1): 399-405.
Published: 19 January 2011
... candidate to identify new biomarkers. Backing this claim for a perspective in clinical practice are recent discoveries that even seemingly subtle changes in the glycan structure of glycoproteins, such as a N-glycan core substitution by a single sugar moiety, have far-reaching functional consequences. They...
Articles
Biochem Soc Trans (2011) 39 (1): 327-330.
Published: 19 January 2011
...Jayne E. Telford; Margaret A. Doherty; Tharmala Tharmalingam; Pauline M. Rudd Glycosylation modifications have been reported in a number of disease states and, as a result, there is significant focus on the discovery and development of glycan-based biomarkers. Glyco-biomarkers have the potential to...
Articles
Biochem Soc Trans (2010) 38 (5): 1374-1377.
Published: 24 September 2010
... Society 2010 biomarker glycosylation high-throughput glycoanalysis HPLC systems biology Glycosylation of proteins is among the most abundant and important post-translational modifications of proteins, which is evidenced by the functions it plays in diverse biological processes, e.g. in...
Articles
Biochem Soc Trans (2010) 38 (2): 343-347.
Published: 22 March 2010
...Qizhi Huang; Laura J. Hardie Biomarkers are needed to screen multiple stages in the clinical pathway of Barrett's oesophagus patients; from disease diagnosis to risk stratification and predicting response to therapy. Routes to the identification of biomarkers have been recognized by known molecular...
Articles
Biochem Soc Trans (2010) 38 (1): 297-300.
Published: 19 January 2010
...Clare R. Foster; Stefan A. Przyborski; Robert G. Wilson; Christopher J. Hutchison Lamins are multifunctional proteins that are often aberrantly expressed or localized in tumours. Here, we endeavour to assess their uses as cancer biomarkers: to diagnose tumours, analyse cancer characteristics and...
Articles
Biochem Soc Trans (2009) 37 (4): 868-872.
Published: 22 July 2009
... quantification and identification of novel biomarkers of chronic lung diseases using techniques such as proteomics. 1 To whom correspondence should be addressed (email bln1@soton.ac.uk ). 4 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 biomarker chronic lung...
Articles
Biochem Soc Trans (2009) 37 (4): 855-862.
Published: 22 July 2009
... implemented. For over a decade, microarrays have provided novel insight into many complex human diseases. Microarray-based discovery can be classified into three components, biomarker detection, disease (sub)classification and identification of causal mechanism, in order of accomplishment. Within the...
Articles
Biochem Soc Trans (2008) 36 (6): 1350-1353.
Published: 19 November 2008
... tumours. Consequently, lamin A/C is a prognostic biomarker in CRC. In vitro studies suggest that lamin A is an upstream regulator of a pathway linking actin dynamics to loss of cell adhesion, leading to enhanced cell motility and consequently increased invasive potential within a tumour. The finding that...
Articles
Biochem Soc Trans (2008) 36 (5): 1071-1076.
Published: 19 September 2008
... correspondence should be addressed (email s.loft@pubhealth.ku.dk ). 30 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 base excision repair biomarker DNA damage DNA repair nucleotide excision repair oxidative damage Multiple exogenous and endogenous...
Articles
Biochem Soc Trans (2008) 36 (5): 1077-1082.
Published: 19 September 2008
... offers potential for development of novel biomarkers of inflammatory diseases. In the present paper, we review some of the progress that has been made towards this goal. 1 To whom correspondence should be addressed (email c.m.spickett@strath.ac.uk ). 30 5 2008 © The Authors Journal...
Articles
Biochem Soc Trans (2007) 35 (5): 1358-1363.
Published: 25 October 2007
... development of reliable biomarkers. 1 To whom correspondence should be addressed (email mmm2@le.ac.uk ). 6 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 biomarker chemoprevention indole plasma profiling polyphenol tumour subtype Epidemiology...
Articles
Biochem Soc Trans (2006) 34 (6): 1159-1160.
Published: 25 October 2006
... bioremediation, natural product synthesis and its manipulation, tools for exploiting CYPs and using CYPs as biomarkers and drug targets. Fundamental studies on diverse structure and function, on the ecological and evolution of CYPs through geological time and in drug/pesticide resistance also contribute...
Articles
Biochem Soc Trans (2002) 30 (2): 82-87.
Published: 01 April 2002
... of suitable binding molecules that can cope effectively with protein diversity. The second format involves the capture of proteins by biochemical or intermolecular interaction, coupled with direct detection by MS. This technology is available as the ProteinChip® Biomarker System. ProteinChip...