... dysregulation of Ca 2+ signals have been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder and Alzheimer's disease. 1 email [email protected] 13 12 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012...

...Sophia Frangou BD (bipolar disorder) is among the ten most significant causes of disability worldwide. Neuroscientists and clinicians have yet to meet the challenge of reducing this disability burden. The main obstacle to date has been our incomplete understanding of the pathophysiology of BD which...

...Richard P. Bazinet Although lithium has been used therapeutically to treat patients with bipolar disorder for over 50 years, its mechanism of action, as well as that of other drugs used to treat bipolar disorder, is not agreed upon. In the present paper, I review studies in unanaesthetized rats...

...S. Hossein Fatemi; Teri J. Reutiman; Timothy D. Folsom Bipolar disorder is a debilitating disorder of the brain with a lifetime prevalence of 1.0% for bipolar I, 1.1% for bipolar II disorder and 2.4–4.7% for subthreshold bipolar disorder. Medications, including lithium, have demonstrated efficacy...

...W. Timothy O'Brien; Peter S. Klein Lithium is widely used to treat bipolar disorder, but its mechanism of action in this disorder is unknown. Lithium directly inhibits GSK3 (glycogen synthase kinase 3), a critical regulator of multiple signal transduction pathways. Inhibition of GSK3 provides...

...Marcella Bellani; Ping-Hong Yeh; Michele Tansella; Matteo Balestrieri; Jair C. Soares; Paolo Brambilla Although the pathogenesis of bipolar disorder is still not completely understood, there is evidence from imaging studies that abnormalities in inter-hemispheric communication may play a major role...

... of which may be associated with bipolar disorder. 1 To whom correspondence should be addressed: (email [email protected] ) 20 4 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 bipolar disorder inositol depletion inositol phosphate myo -inositol...

...Nicole Terbach; Robin S.B. Williams The anticonvulsant properties of VPA (valproic acid), a branched short-chain fatty acid, were serendipitously discovered in 1963. Since then, therapeutic roles of VPA have increased to include bipolar disorder and migraine prophylaxis, and have more recently been...

... Journal compilation © 2009 Biochemical Society 2009 bipolar disorder chemotaxis Dictyostelium inositol depletion neuronal cell biology phosphatidylinositol 3,4,5-trisphosphate phosphatidylinositol 4,5-bisphosphate Bipolar mood disorder is a chronic psychiatric disorder characterized...

... compilation © 2009 Biochemical Society 2009 bipolar disorder H + – myo -inositol transporter (HMIT) myo -inositol-1-phosphate synthase (MIP-synthase) phosphoinositide sodium– myo -inositol transporter (SMIT) BD (bipolar disorder) or manic depression is a severe and common psychiatric...

...Robin S.B. Williams BD (bipolar disorder) is a devastating condition, giving rise to debilitating mood swings and a greatly increased likelihood of suicide. Research into the origins, progression and treatment of BD has been slow, primarily due to lack of suitable model systems for BD research...

.... bipolar disorder glycogen synthase kinase 3β (GSK3β) inositol monophosphatase (IMPase) knockout mouse lithium sodium– myo -inositol transporter (SMIT) 1 To whom correspondence should be addressed (email [email protected] ). 13 4 2009 © The Authors Journal compilation © 2009...

...-stabilizing effects of VPA and LiCl in bipolar disorder. 1 To whom correspondence should be addressed (email [email protected] ). 29 4 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 This work was supported by the Eda Lady Jardine Trust (S.V.) and the Henry...