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Keywords: brain
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Biochem Soc Trans (2023) 51 (1): 259–274.
Published: 06 January 2023
.... As the major immune cells in the brain, reactive microglia play a central role in neuroinflammation by responding directly or indirectly to viruses. Chronic reactivity of microglia leads to functions that are distinct from their beneficial roles under physiological conditions and may result in neuronal damage...
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Biochem Soc Trans (2022) 50 (6): 1693–1702.
Published: 16 November 2022
...Dawn M. Wenzel; Stephanie Olivier-Van Stichelen Proper neuronal development is essential to growth and adult brain function. Alterations at any step of this highly organized sequence of events, due to genetic mutations or environmental factors, triggers brain malformations, which are leading causes...
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Biochem Soc Trans (2015) 43 (4): 572–578.
Published: 03 August 2015
... in steroid biosynthesis. 1 Correspondence may be addressed to either author (email [email protected] or [email protected] ) . 16 3 2015 © 2015 Authors; published by Portland Press Limited 2015 14-3-3 proteins adrenal aging brain cholesterol gonads...
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Biochem Soc Trans (2010) 38 (4): 841–860.
Published: 26 July 2010
... and brain subjected to reperfusion after a period of ischaemia as may occur during treatment of a myocardial infarction or stroke and during heart surgery. In the present article, I review the properties, regulation and molecular composition of the MPTP. The evidence for the roles of CyP-D (cyclophilin D...
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Biochem Soc Trans (2010) 38 (2): 457–459.
Published: 22 March 2010
...David G. Nicholls Synaptosomes (isolated nerve terminals) have been studied for more than 40 years. The preparation allows aspects of transmitter metabolism and release to be studied ex vivo from specific brain regions of animals of any age. Conditions can be devised to enable the terminals to fire...
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Biochem Soc Trans (2009) 37 (6): 1261–1262.
Published: 19 November 2009
...Ian C. Wood; Nicola K. Gray; Lesley Jones The brain is the most complex organ of the body and it contains the greatest diversity of cell types. Collectively, the cells within the brain express the greatest number of genes encoded within our genome. Inappropriate gene expression within these cells...
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Biochem Soc Trans (2009) 37 (6): 1276–1277.
Published: 19 November 2009
...) in expression [ 5 , 6 ]. Interestingly, trans variability was more pronounced when lymphoblasts were stimulated [ 6 ]. 1 To whom correspondence should be addressed (email [email protected] ). 19 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 brain...
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Biochem Soc Trans (2009) 37 (6): 1334–1337.
Published: 19 November 2009
... correspondence should be addressed (email [email protected] ). 6 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 benzodiazepine brain conductance γ-aminobutyric acid subtype A receptor (GABA A R) hippocampal pyramidal neuron long-term potentiation (LTP...
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Biochem Soc Trans (2008) 36 (6): 1267–1271.
Published: 19 November 2008
... Journal compilation © 2008 Biochemical Society 2008 brain development fetal iron deficiency hippocampus iron memory Metal Metabolism: Transport, Development and Neurodegeneration: A Biochemical Society Focused Meeting held at Imperial College London, U.K., 9–10 July 2008. Organized...
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Biochem Soc Trans (2007) 35 (5): 1133–1137.
Published: 25 October 2007
...) isoform and summarizes the outcomes of experimental stroke studies with regard to the therapeutic utility of nitric oxide donors and NOS inhibitors. brain cerebral ischaemia inducible nitric oxide synthase (iNOS) inflammation nitric oxide progesterone A brief period of exposure...
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Biochem Soc Trans (2007) 35 (3): 588–593.
Published: 22 May 2007
... by protein fragments produced post-mortem during conventional sample handling. Nanoflow liquid chromatography and MS, together with improved methods for sample preparation, have been used to semi-quantitatively monitor endogenous peptides in brain tissue. When rapidly heat-denatured brain tissue was analysed...
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Biochem Soc Trans (2006) 34 (5): 828–832.
Published: 25 October 2006
... by stress-activated MAPKs are the JIPs [JNK (c-Jun N-terminal kinase)-interacting proteins]. JIP proteins have been demonstrated to form complexes with specific JNK and p38 MAPK signalling modules and to play important roles in brain development, neuronal trafficking, apoptosis, β-cell function and insulin...
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Biochem Soc Trans (2006) 34 (6): 1307–1309.
Published: 25 October 2006
... the brain and nervous system. Preconditioning has been investigated in cell and animal models and recently been shown to potentially occur in human brain. Learning more about these powerful endogenous neuroprotective mechanisms could help identify new approaches to treat patients with stroke and other...
Articles
Biochem Soc Trans (2006) 34 (2): 232–237.
Published: 20 March 2006
... cell death of the heart and brain that occurs during reperfusion after a long period of ischaemia. Such reperfusion injury is a major problem during cardiac surgery and in the treatment of coronary thrombosis and stroke. Prevention of MPTP opening either directly, using agents such as cyclosporin...
Articles
Biochem Soc Trans (2004) 32 (6): 1032–1036.
Published: 26 October 2004
... The Biochemical Society 2004 brain D 1 receptor dopamine glutamate N -methyl- D -aspartate receptor (NMDA receptor) The overlap and convergence of both dopaminergic and glutamatergic projections in the mammalian brain provides the architectural framework for complex neuronal interactions...