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Keywords: brain aging
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Articles

Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling

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Fei Yin, Tianyi Jiang, Enrique Cadenas
Journal: Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 101–105.
https://doi.org/10.1042/BST20120260
Published: 29 January 2013
... Journal compilation © 2013 Biochemical Society 2013 brain aging c-Jun N-terminal kinase (JNK) energy metabolism insulin/insulin-like growth factor-1 signalling mitochondrion neurodegeneration A decrease in energy metabolism, leading to a hypometabolic state, is associated with brain...
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Articles

Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?

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G.J. Biessels, L.J. Kappelle
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1041–1044.
https://doi.org/10.1042/BST0331041
Published: 26 October 2005
... and learning and memory, and disturbances in insulin signalling pathways in the periphery and in the brain have recently been implicated in Alzheimer's disease and brain aging. Insulin also regulates the metabolism of β-amyloid and tau, the building blocks of amyloid plaques and neurofibrillary tangles...
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