... Journal compilation © 2013 Biochemical Society 2013 brain aging c-Jun N-terminal kinase (JNK) energy metabolism insulin/insulin-like growth factor-1 signalling mitochondrion neurodegeneration A decrease in energy metabolism, leading to a hypometabolic state, is associated with brain...

... will be of critical importance to validate MKK4 and MKK7 as promising drug targets. 1 To whom correspondence should be addressed (email [email protected] ). 5 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 cancer c-Jun N-terminal kinase (JNK...

... conjugation with ATF7 delays its nuclear transport and impairs ATF7 transactivation activity by inhibition of its binding to specific sequences in target gene promoters [ 17 ]. activating transcription factor 2 (ATF2) activating transcription factor 7 (ATF7) activator protein 1 (AP-1) c-Jun N-terminal...

... The Biochemical Society 2004 apoptosis c-Jun N-terminal kinase (JNK) mitochondria signal transduction stress kinase Multiple MAP (mitogen-activated protein) kinase pathways exist within vertebrate cells, leading to the activation of extracellular-signal-regulated kinase, JNK (c-Jun N-terminal...