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Keywords: cAMP
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Articles
Biochem Soc Trans (2021) 49 (2): 997–1011.
Published: 16 April 2021
...Jonathan K.H. Li; Pei F. Lai; Rachel M. Tribe; Mark R. Johnson Cyclic adenosine monophosphate (cAMP) contributes to maintenance of a quiescent (relaxed) state in the myometrium (i.e. uterine smooth muscle) during pregnancy, which most commonly has been attributed to activation of protein kinase A...
Articles
Biochem Soc Trans (2020) 48 (3): 799–811.
Published: 29 June 2020
... mitochondrial dysfunction. DEP impair structural cell function and initiate the epithelial-to-mesenchymal transition, a process leading to dysfunction in endothelial as well as epithelial barrier, hamper tissue repair and eventually leading to fibrosis. Targeting cyclic adenosine monophosphate (cAMP) has been...
Articles
Biochem Soc Trans (2020) 48 (1): 61–70.
Published: 27 February 2020
...Aleksandra Judina; Julia Gorelik; Peter T. Wright Multiple intra-cellular signalling pathways rely on calcium and 3′–5′ cyclic adenosine monophosphate (cAMP) to act as secondary messengers. This is especially true in cardiomyocytes which act as the force-producing units of the cardiac muscle and...
Articles
Biochem Soc Trans (2019) 47 (6): 1749–1756.
Published: 26 November 2019
...Autumn N. Marsden; Carmen W. Dessauer Adenylyl cyclases (ACs) convert ATP into the classical second messenger cyclic adenosine monophosphate (cAMP). Cardiac ACs, specifically AC5, AC6, and AC9, regulate cAMP signaling controlling functional outcomes such as heart rate, contractility and relaxation...
Articles
Biochem Soc Trans (2019) 47 (6): 1733–1747.
Published: 14 November 2019
...Christina Klausen; Fabian Kaiser; Birthe Stüven; Jan N. Hansen; Dagmar Wachten The second messenger 3′,5′-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil...
Articles
Biochem Soc Trans (2019) 47 (5): 1383–1392.
Published: 31 October 2019
...Ying-Chi Chao; Nicoletta C. Surdo; Sergio Pantano; Manuela Zaccolo 3′-5′-cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that modulates multiple cellular functions. It is now well established that cAMP can mediate a plethora of functional effects via a complex system of local...
Articles
Biochem Soc Trans (2019) 47 (5): 1557–1565.
Published: 23 October 2019
... this context. This review discusses the role of PDE4 in the orchestration of cAMP response element binding signaling in AD and outlines the benefits of targeting PDE4D specifically. We examine the limited available literature that suggests PDE4 expression does not change in AD brains together with...
Articles
Biochem Soc Trans (2019) 47 (5): 1355–1366.
Published: 11 October 2019
...Matthew G. Gold cAMP-dependent protein kinase (PKA) plays a central role in important biological processes including synaptic plasticity and sympathetic stimulation of the heart. Elevations of cAMP trigger release of PKA catalytic (C) subunits from PKA holoenzymes, thereby coupling cAMP to protein...
Articles
Biochem Soc Trans (2019) 47 (5): 1415–1427.
Published: 11 October 2019
... activity modulators, including cyclic nucleotides, sulphonylureas, and N -acylsulphonamides. While cAMP activates both EPAC1 and EPAC2, many isoform-selective eight substituted cAMP analogues have been reported, the thioarylnucleotide 007 and its acetoxymethyl derivative 007-AM as well as the EPAC2...
Articles
Biochem Soc Trans (2019) 47 (5): 1405–1414.
Published: 10 September 2019
...Connor M. Blair; George S. Baillie Spatio-temporal regulation of localised cAMP nanodomains is highly dependent upon the compartmentalised activity of phosphodiesterase (PDE) cyclic nucleotide degrading enzymes. Strategically positioned PDE–protein complexes are pivotal to the homeostatic control...
Articles
Biochem Soc Trans (2019) 47 (4): 1143–1156.
Published: 24 July 2019
... progression, as well as the transcription of suppressor of cytokine signalling 3 (SOCS3) which limits IL-6 signalling. Current PAH therapies include prostanoid drugs which induce vasodilation via stimulating intracellular 3′,5′-cyclic adenosine monophosphate (cAMP) levels. cAMP can also inhibit IL-6-mediated...
Articles
Biochem Soc Trans (2017) 45 (1): 269–274.
Published: 15 February 2017
...Stefania Monterisi; Manuela Zaccolo 3′-5′-Cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signalling is activated by different extracellular stimuli and mediates many diverse processes within the same cell. It is now well established that in order to translate into the appropriate...
Articles
Biochem Soc Trans (2016) 44 (2): 562–567.
Published: 11 April 2016
... to selectively and therapeutically target GPCRs. In thyroid follicles isolated from mice transgenic for a FRET-based cAMP biosensor (Epac1-camps [ 32 ]) the TSHR elicits quite distinct cellular outcomes dependent on the duration of receptor stimulation [ 29 ]. A short, 30 s, stimulation of the...
Articles
Biochem Soc Trans (2014) 42 (2): 279–283.
Published: 20 March 2014
...Ahmed Aburima; Khalid M. Naseem MLCP (myosin light chain phosphatase) regulates platelet function through its ability to control myosin IIa phosphorylation. Recent evidence suggests that MLCP is a de facto target for signalling events stimulated by cAMP. In the present mini-review, we discuss the...
Articles
Biochem Soc Trans (2014) 42 (2): 284–288.
Published: 20 March 2014
... hallmark of cardiovascular disease, knowledge of caveolae-dependent cytokine signalling is lacking as is the role of cavin-1 independent of caveolae. The present review introduces caveolae, their structural components, the caveolins and cavins, their regulation by cAMP, and their potential role in...
Articles
Biochem Soc Trans (2014) 42 (2): 289–294.
Published: 20 March 2014
...Zaher Raslan; Khalid M. Naseem Blood platelet activation must be tightly regulated to ensure a balance between haemostasis and thrombosis. The cAMP signalling pathway is the most powerful endogenous regulator of blood platelet activation. PKA (protein kinase A), the foremost effector of cAMP...
Articles
Biochem Soc Trans (2014) 42 (2): 250–256.
Published: 20 March 2014
...Donald H. Maurice; Lindsay S. Wilson; Sarah N. Rampersad; Fabien Hubert; Tammy Truong; Milosz Kaczmarek; Paulina Brzezinska; Silja I. Freitag; M. Bibiana Umana; Alie Wudwud The cyclic nucleotide second messengers cAMP and cGMP each affect virtually all cellular processes. Although these hydrophilic...
Articles
Biochem Soc Trans (2014) 42 (2): 257–264.
Published: 20 March 2014
...Malik Bisserier; Jean-Paul Blondeau; Frank Lezoualc’h Epacs (exchange proteins directly activated by cAMP) act as guanine-nucleotide-exchange factors for the Ras-like small G-proteins Rap1 and Rap2, and are now recognized as incontrovertible factors leading to complex and diversified cAMP...
Articles
Biochem Soc Trans (2014) 42 (2): 265–269.
Published: 20 March 2014
... domains and therefore participate in a variety of important cellular actions such as ATP synthesis and programmed cell death. In a surprising homology, it is now widely accepted that the ubiquitous second messenger cAMP uses the same stratagem, compartmentalization, in order to achieve the characteristic...
Articles
Biochem Soc Trans (2014) 42 (2): 295–301.
Published: 20 March 2014
... zebrafish revealed an overlapping role for proper electrical conduction in the heart and maintaining structural integrity of skeletal muscle. Popdc proteins mediate cAMP signalling and modulate the biological activity of interacting proteins. The two-pore channel TREK-1 interacts with all three Popdc...
Articles
Biochem Soc Trans (2014) 42 (2): 270–273.
Published: 20 March 2014
... muscle. Phosphorylation at Ser 16 by PKA (cAMP-dependent protein kinase) is essential for HSP20 to confer its protective qualities. HSP20 and its phosphorylation have been implicated in a variety of pathophysiological processes, but most prominently cardiovascular disease. A wealth of knowledge of the...
Articles
Biochem Soc Trans (2014) 42 (2): 302–307.
Published: 20 March 2014
...Stephen Boulton; Madoka Akimoto; Bryan VanSchouwen; Kody Moleschi; Rajeevan Selvaratnam; Rajanish Giri; Giuseppe Melacini Eukaryotic CBDs (cAMP-binding domains) control multiple cellular functions (e.g. phosphorylation, guanine exchange and ion channel gating). Hence the manipulation of cAMP...
Articles
Biochem Soc Trans (2014) 42 (1): 89–97.
Published: 23 January 2014
...Owain Llŷr Roberts; Caroline Dart The second messenger cAMP plays a central role in mediating vascular smooth muscle relaxation in response to vasoactive transmitters and in strengthening endothelial cell–cell junctions that regulate the movement of solutes, cells and macromolecules between the...
Articles
Biochem Soc Trans (2014) 42 (1): 139–144.
Published: 23 January 2014
...-relieving mutations. 1 To whom correspondence should be addressed (email melacin@mcmaster.ca ). 13 11 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 allostery cAMP cGMP covariance NMR protein dynamics singular value decomposition (SVD...
Articles
Biochem Soc Trans (2014) 42 (1): 63–70.
Published: 23 January 2014
.... Similar structural changes are thought to allow gating of ryanodine receptors. cAMP increases the sensitivity of IP 3 Rs and thereby potentiates the Ca 2+ signals evoked by receptors that stimulate IP 3 formation. We speculate that both IP 3 and cAMP are delivered to IP 3 Rs within signalling junctions...
Articles
Biochem Soc Trans (2013) 41 (6): 1692–1695.
Published: 20 November 2013
... Society 2013 cAMP cyclic nucleotide phosphodiesterase genetic screen high-throughput screen protein kinase A Schizosaccharomyces pombe PKA (protein kinase A, also known as cAMP-dependent protein kinase), is a serine/threonine kinase involved in many eukaryotic processes, including...
Articles
Biochem Soc Trans (2012) 40 (1): 179–183.
Published: 19 January 2012
...Katy L. Everett; Dermot M.F. Cooper The development of FRET (fluorescence resonance energy transfer)-based sensors for measuring cAMP has opened the door to sophisticated insights into single-cell cAMP dynamics. cAMP can be measured in distinct cell populations and even in distinct microdomains...
Articles
Biochem Soc Trans (2012) 40 (1): 1–5.
Published: 19 January 2012
... lesion sites may be just as important. Indeed, elevated IL-6 (interleukin 6) levels are as strongly associated with coronary heart disease as increased cholesterol. We have been investigating novel cAMP-regulated pathways that combat the action of pro-inflammatory cytokines, such as IL-6 and leptin, in...
Articles
Biochem Soc Trans (2012) 40 (1): 147–152.
Published: 19 January 2012
... proteins and PTHR1. In addition, cAMP itself can, via Epac (exchange protein directly activated by cAMP), PKA (protein kinase A) or by binding directly to IP 3 Rs [Ins(1,4,5) P 3 receptors] regulate [Ca 2+ ] i . Epac leads to activation of PLCϵ, PKA can phosphorylate and thereby increase the sensitivity of...
Articles
Biochem Soc Trans (2012) 40 (1): 11–14.
Published: 19 January 2012
...Alessandra Stangherlin; Manuela Zaccolo cAMP and cGMP signalling pathways are common targets in the pharmacological treatment of heart failure, and often drugs that modulate the level of these second messengers are simultaneously administered to patients. cGMP can potentially affect cAMP levels by...
Articles
Biochem Soc Trans (2012) 40 (1): 219–223.
Published: 19 January 2012
...Rajeevan Selvaratnam; Madoka Akimoto; Bryan VanSchouwen; Giuseppe Melacini Epac (exchange protein directly activated by cAMP) is a critical cAMP receptor, which senses cAMP and couples the cAMP signal to the catalysis of guanine exchange in the Rap substrate. In the present paper, we review the NMR...
Articles
Biochem Soc Trans (2012) 40 (1): 44–50.
Published: 19 January 2012
... have revealed essential contributions by intracellular signalling mechanisms. cAMP and Ca 2+ signalling are not only regulated by the cellular clock, but also contribute directly to the timekeeping mechanism, in that appropriate manipulations determine the canonical pacemaker properties of amplitude...
Articles
Biochem Soc Trans (2012) 40 (1): 51–57.
Published: 19 January 2012
...Anne-Coline Laurent; Magali Breckler; Magali Berthouze; Frank Lezoualc'h Epacs (exchange proteins directly activated by cAMP) are guanine-nucleotide-exchange factors for the Ras-like small GTPases Rap1 and Rap2. Epacs were discovered in 1998 as new sensors for the second messenger cAMP acting in...
Articles
Biochem Soc Trans (2007) 35 (5): 1035–1037.
Published: 25 October 2007
... investigated the hypothesis that the β 3a -AR interacts with caveolin. Disruption of caveolae in CHO (Chinese-hamster ovary)-K1 cells expressing wild-type β 3a -ARs with filipin III, or mutation of a putative caveolin-binding site in the β 3a -AR, causes cAMP accumulation to become PTX (pertussis toxin...
Articles
Biochem Soc Trans (2007) 35 (5): 931–937.
Published: 25 October 2007
...E. Jarnæss; K. Taskén Ligand-induced changes in cAMP concentration vary in duration, amplitude and extension into the cell. cAMP microdomains are shaped by adenylate cyclases that form cAMP as well as PDEs (phosphodiesterases) that degrade cAMP. Various extracellular signals converge on the cAMP...
Articles
Biochem Soc Trans (2006) 34 (4): 468–471.
Published: 21 July 2006
...D. Willoughby; D.M.F. Cooper cAMP is a ubiquitous intracellular signalling molecule that can regulate a wide array of cellular processes. The diversity of action of this second messenger owes much to the localized generation, action and hydrolysis of cAMP within discrete subcellular regions...
Articles
Biochem Soc Trans (2006) 34 (4): 510–511.
Published: 21 July 2006
...M. Mongillo; M. Zaccolo β-Adrenergic signalling mediates the positive inotropic effect of catecholamines on cardiomyocytes, mainly through cAMP generation and subsequent activation of PKA (protein kinase A). Given the large diversity of PKA targets within cardiac cells, a precisely regulated and...
Articles
Biochem Soc Trans (2006) 34 (4): 472–473.
Published: 21 July 2006
... tools to study the relevance of PKA anchoring in cellular processes. 1 To whom correspondence should be addressed (email klussmann@fmp-berlin.de ). 6 4 2006 © 2006 The Biochemical Society 2006 A-kinase-anchoring protein (AKAP) aquaporin-2 (AQP2) cAMP exocytosis protein...
Articles
Biochem Soc Trans (2006) 34 (4): 498–501.
Published: 21 July 2006
...O. Dyachok; J. Sågetorp; Y. Isakov; A. Tengholm Activation of hormone receptors was recently found to evoke oscillations of the cAMP concentration ([cAMP]) beneath the plasma membrane of insulin-secreting cells. Here we investigate how different time courses of cAMP signals influence the generation...
Articles
Biochem Soc Trans (2006) 34 (4): 484–488.
Published: 21 July 2006
...G. Vandecasteele; F. Rochais; A. Abi-Gerges; R. Fischmeister The cAMP pathway is of cardinal importance for heart physiology and pathology. The spatial organization of the various components of the cAMP pathway is thought to allow the segregation of functional responses triggered by the different...
Articles
Biochem Soc Trans (2006) 34 (4): 515–517.
Published: 21 July 2006
..., including Ca 2+ and cAMP, that lie downstream of G s is not resolved. 1 To whom correspondence should be addressed (email cwt1000@cam.ac.uk ). 4 5 2006 © 2006 The Biochemical Society 2006 calcium cAMP G-protein inositol 1,4,5-trisphosphate intracellular signalling parathyroid...
Articles
Biochem Soc Trans (2006) 34 (4): 502–503.
Published: 21 July 2006
... involvement in regulating cardiac functions. In this tissue, PI3Kγ acts as a negative modulator of contractility, by decreasing cAMP concentration through a kinase-independent mechanism. Indeed, whereas PI3Kγ-deficient mice show an abnormal cAMP elevation, cAMP levels in knock-in mouse mutants, expressing a...
Articles
Biochem Soc Trans (2006) 34 (4): 489–491.
Published: 21 July 2006
...@biotek.uio.no ). 28 3 2006 © 2006 The Biochemical Society 2006 A-kinase-anchoring protein (AKAP) cAMP excitation–contraction coupling heart phospholamban (PLB) protein kinase A (PKA) sarcoplasmic/endoplasmic-reticulum Ca 2+ -ATPase 2 (SERCA2) Contraction and relaxation of heart...
Articles
Biochem Soc Trans (2006) 34 (4): 492–494.
Published: 21 July 2006
...S. Sayner; T. Stevens Within pulmonary microvascular endothelial cells, activation of endogenous adenylate cyclase generates tightly regulated cAMP transitions in the subplasma membrane space. These cAMP fluxes strengthen contacts between adjacent cells to tighten their barrier function. However...
Articles
Biochem Soc Trans (2006) 34 (4): 476–479.
Published: 21 July 2006
...K. Taskén; A.J. Stokka cAMP inhibits Src-family kinase signalling by PKA (protein kinase A)-mediated phosphorylation and activation of Csk (C-terminal Src kinase). The PKA type I–Csk pathway is assembled and localized in membrane microdomains (lipid rafts) and regulates immune responses activated...
Articles
Biochem Soc Trans (2005) 33 (6): 1323–1326.
Published: 26 October 2005
...M. Zaccolo; T. Cesetti; G. Di Benedetto; M. Mongillo; V. Lissandron; A. Terrin; I. Zamparo In recent years, the development of new technologies based on the green fluorescent protein and FRET (fluorescence resonance energy transfer) has introduced a new perspective in the study of cAMP signalling...
Articles
Biochem Soc Trans (2005) 33 (5): 1126–1128.
Published: 26 October 2005
...W.A. Sands; T.M. Palmer The anti-inflammatory effects of the prototypical second messenger cAMP have been extensively documented in multiple cell types. However, in many instances, the molecular mechanisms by which cAMP elevation disrupts specific pro-inflammatory signalling cascades are unknown...
Articles
Biochem Soc Trans (2005) 33 (6): 1327–1329.
Published: 26 October 2005
...S.J. Yarwood cAMP is an essential signalling molecule whose concentration in cells is regulated by a wide range of hormones. A large number of diseases, including cancer and asthma, are linked to improper regulation of the cAMP signalling system, and manipulation of cAMP levels by pharmaceutical...
Articles
Biochem Soc Trans (2005) 33 (6): 1330–1332.
Published: 26 October 2005
...I. McPhee; L.C.D. Gibson; J. Kewney; C. Darroch; P.A. Stevens; D. Spinks; A. Cooreman; S.J. MacKenzie The EPAC (exchange protein directly activated by cAMP) proteins are GEFs (guanine nucleotide-exchange factors) that activate Rap GTPases upon binding to cAMP. The involvement of these proteins in a...
Articles
Biochem Soc Trans (2005) 33 (6): 1333–1336.
Published: 26 October 2005
... isoform preferentially interacts with the signalling scaffold protein β-arrestin and is thereby recruited to the β 2 -AR upon agonist challenge. Delivery of an active PDE to the site of cAMP synthesis at the plasma membrane specifically attenuates the activity of a pool of PKA (protein kinase A) that is...