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Keywords: cAMP-specific phosphodiesterase-4 (PDE4)
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Biochem Soc Trans (2006) 34 (4): 474–475.
Published: 21 July 2006
... phosphodiesterase-4 (PDE4) G-protein receptor kinase-2 (GRK2) rolipram GPCRs (G-protein-coupled receptors) mediate cellular responses to a plethora of environmental stimuli through the activation of heterotrimeric G-proteins [ 1 ]. GPCR stimulation initiates a variety of intracellular signals, including...