1-10 of 10
Keywords: cGMP
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem Soc Trans (2019) 47 (5): 1327–1339.
Published: 11 October 2019
...Nadja I. Bork; Cristina E. Molina; Viacheslav O. Nikolaev 3′,5′-Cyclic guanosine monophosphate (cGMP) is one of the major second messengers critically involved in the regulation of cardiac electrophysiology, hypertrophy, and contractility. Recent molecular and cellular studies have significantly...
Articles
Biochem Soc Trans (2018) 46 (6): 1729–1742.
Published: 12 November 2018
... associated with human disease, and either abolish or enhance cGMP production by these receptors to alter downstream signaling events. This raises the interesting possibility that one could identify molecules that bind to the pseudokinase domain and regulate the activities of these receptors, in order to...
Articles
Biochem Soc Trans (2014) 42 (2): 250–256.
Published: 20 March 2014
...Donald H. Maurice; Lindsay S. Wilson; Sarah N. Rampersad; Fabien Hubert; Tammy Truong; Milosz Kaczmarek; Paulina Brzezinska; Silja I. Freitag; M. Bibiana Umana; Alie Wudwud The cyclic nucleotide second messengers cAMP and cGMP each affect virtually all cellular processes. Although these hydrophilic...
Articles
Biochem Soc Trans (2014) 42 (1): 108–113.
Published: 23 January 2014
...Opher Gileadi Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery...
Articles
Biochem Soc Trans (2014) 42 (1): 139–144.
Published: 23 January 2014
...-relieving mutations. 1 To whom correspondence should be addressed (email melacin@mcmaster.ca ). 13 11 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 allostery cAMP cGMP covariance NMR protein dynamics singular value decomposition (SVD...
Articles
Biochem Soc Trans (2012) 40 (1): 11–14.
Published: 19 January 2012
...Alessandra Stangherlin; Manuela Zaccolo cAMP and cGMP signalling pathways are common targets in the pharmacological treatment of heart failure, and often drugs that modulate the level of these second messengers are simultaneously administered to patients. cGMP can potentially affect cAMP levels by...
Articles
Biochem Soc Trans (2012) 40 (1): 219–223.
Published: 19 January 2012
... activation of Epac, but also to the selectivity of Epac for cAMP in contrast with cGMP. In addition, we have mapped the interaction networks that couple the cAMP-binding site to the sites involved in the autoinhibitory interactions, using a method based on the covariance analysis of NMR chemical shifts. We...
Articles
Biochem Soc Trans (2006) 34 (4): 512–514.
Published: 21 July 2006
...S.-A. Davies; J.P. Day The biochemical aspects of cGMP signalling are well known, although in vivo roles of cGMP have only been recently discovered through work in genetic model organisms. The Drosophila melanogaster Malpighian (renal) tubule has been used to address the roles of cGMP in epithelial...
Articles
Biochem Soc Trans (2004) 32 (5): 792–796.
Published: 26 October 2004
...H. Wang; Y. Lee; C.C. Malbon Wnt signalling in development operates via members of the Frizzleds, G-protein-coupled receptors that bind specific Wnt ligands and mediate signalling via distinct pathways. The Wnt/Ca 2+ /cGMP pathway mediated by Frizzled-2 was discovered recently. Activation of this...
Articles
Biochem Soc Trans (2004) 32 (1): 110–112.
Published: 01 February 2004
... expression of the inducible cyclo-oxygenase COX-2 and increased prostacyclin synthesis in a biphasic manner. Studies with the COX-2-selective inhibitor NS-398 confirmed the COX-2 dependency of the later increase in prostanoid production. Pre-incubation with CMR-LPs reduced basal and thrombin-stimulated cGMP...