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Keywords: calcium
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (4): 1939–1946.
Published: 22 August 2024
.... In physiology Ca 2+ can regulate and trigger reactive oxygen species (ROS) production by various enzymes and in mitochondria but ROS could also transmit redox signal to calcium levels via modification of calcium channels or phospholipase activity. Changes in calcium or redox signalling could lead to severe...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 937–945.
Published: 27 March 2024
...Guanyu Lin; Madison Rennie; Ayobami Adeeko; Suzanne Scarlata Calcium is a primary second messenger that plays a role in cellular functions including growth, movement and responses to drugs. The role that calcium plays in mediating communication between neurons by synaptic vesicle release is well...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1437–1445.
Published: 30 June 2023
... 2023 calcium claudin kidney tight junction tubule One of the primary functions of the kidney is regulating water, solute, and electrolyte homeostasis through the control of tubular transport (reabsorption or secretion). Renal tubular transport occurs via the paracellular (between cells...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 61–70.
Published: 27 February 2020
...Aleksandra Judina; Julia Gorelik; Peter T. Wright Multiple intra-cellular signalling pathways rely on calcium and 3′–5′ cyclic adenosine monophosphate (cAMP) to act as secondary messengers. This is especially true in cardiomyocytes which act as the force-producing units of the cardiac muscle...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (6): 1963–1969.
Published: 26 November 2019
... 2019 8 11 2019 8 11 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 bioenergetics calcium complex I mitochondria reactive oxygen species Introduction Mitochondria are distinguishable from the other numerous...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 452–459.
Published: 11 April 2016
..., Edinburgh, U.K., 26–29 October 2015 References 1 Hasselbach W. Makinose M. [The calcium pump of the “relaxing granules” of muscle and its dependence on ATP-splitting] Biochem Z. 1961 333 518 528 13712164 2 Hasselbach W. Makinose M. ATP and active transport Biochem...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 1–6.
Published: 09 February 2016
...Noelia Lander; Ciro Cordeiro; Guozhong Huang; Roberto Docampo Inorganic polyphosphate (polyP) accumulates in acidocalcisomes, acidic calcium stores that have been found from bacteria to human cells. Proton pumps, such as the vacuolar proton pyrophosphatase (V-H + -PPase or VP1), the vacuolar proton...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 253–259.
Published: 09 February 2016
... circle. Whereas the discovery of the IP 3 -mediated calcium release exponentially stimulated research in this field, the evolutionary conservation of inositol phosphate signalling suggests that an alternative, more ancient, mechanism of action may be at play. Clues about this more ancient...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 7–12.
Published: 09 February 2016
...Maria E. Solesio; Pia A. Elustondo; Eleonora Zakharian; Evgeny V. Pavlov Mitochondrial permeability transition pore (mPTP) is a large channel located in the mitochondrial inner membrane. The opening of mPTP during pathological calcium overload leads to the membrane depolarization and disruption...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 202–211.
Published: 09 February 2016
...Robin Irvine Between spring 1982 and autumn 1984 the physiological role of Ins(1,4,5) P 3 as a calcium-mobilizing second messenger was first suggested and then experimentally established. At the same time the unexpected complexity of inositide metabolism began to be exposed by the discovery of Ins...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (3): 502–507.
Published: 01 June 2015
... to the work. 2 To whom correspondence should be addressed (email [email protected] ) . 9 2 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 Pannexin-1 Calcium Platelet Leukocyte Phosphorylation Erythrocyte ATP Caspases The connexin...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (3): 349–358.
Published: 01 June 2015
... reticulum calcium transport ATPase (SERCA) activity [ 18 ], which increases the ER Ca 2+ concentration that then sensitizes both the RYRs and the InsP 3 Rs. In a reciprocal way, entry of Ca 2+ into the mitochondria enhances energy metabolism resulting in an increased formation of superoxide (O 2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (5): 1302–1310.
Published: 18 September 2014
...Terri-Leigh Stephen; Swati Gupta-Agarwal; Josef T. Kittler Astrocytes exhibit cellular excitability through variations in their intracellular calcium (Ca 2+ ) levels in response to synaptic activity. Astrocyte Ca 2+ elevations can trigger the release of neuroactive substances that can modulate...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (5): 1441–1446.
Published: 18 September 2014
... -binding proteins are known targets of calmodulin (CaM), which, depending on the presence of calcium, can compete with PI(4,5)P 2 for protein interaction, translating Ca 2+ transient microdomains into variations of PI(4,5)P 2 lateral organization in time and space. The present review highlights different...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (2): 297–309.
Published: 21 March 2012
... Alzheimer's disease bipolar disorder calcium heart inositol schizophrenia Calcium (Ca 2+ ) is a highly versatile intracellular signal capable of regulating many different processes [ 1 ]. To achieve this versatility, the signalling system operates in many different modes, thus enabling...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 153–157.
Published: 19 January 2012
....)]. References 1 Berridge M.J. Lipp P. Bootman M.D. The versatility and universality of calcium signalling Nat. Rev. Mol. Cell Biol. 2000 1 11 21 2 Parekh A.B. Decoding cytosolic Ca2+ oscillations Trends Biochem. Sci. 2011 36 78 87 3 Sammels E. Parys J.B...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 44–50.
Published: 19 January 2012
... properties of cellular rhythms, i.e. amplitude, phase and period. 1 To whom correspondence should be addressed (email [email protected] ). 3 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 calcium cAMP circadian rhythm clock second...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1136–1141.
Published: 21 September 2011
.... 1 To whom correspondence should be addressed (email [email protected] ). 29 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 actin ATPase activity calcium myosin The myosin superfamily throughout phylogeny consists of at least 35 classes...
Articles
Véronique Deschodt-Arsac, Guillaume Calmettes, Gilles Gouspillou, Richard Rouland, Eric Thiaudiere, Sylvain Miraux, Jean-Michel Franconi, Philippe Diolez
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (5): 1319–1321.
Published: 24 September 2010
... adrenaline calcium Modular Control and Regulation Analysis non-invasive 31 P-NMR perfused heart systems biology Top-down or modular approaches to MCA (Metabolic Control Analysis) have been used by us and others to overcome the complexity of investigating intracellular and intra-organ regulation...
Articles
C. Geoffrey Lau, Koichi Takeuchi, Alma Rodenas-Ruano, Yukihiro Takayasu, Jessica Murphy, Michael V.L. Bennett, R. Suzanne Zukin
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1369–1374.
Published: 19 November 2009
..., MA 02138-2020, U.S.A. 2 To whom correspondence should be addressed (email [email protected] ). 14 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 calcium N -methyl- D -aspartate receptor (NMDAR) protein kinase signalling synaptic...
Articles
Anne-Laure Mahul-Mellier, Flavie Strappazzon, Christine Chatellard-Causse, Béatrice Blot, David Béal, Sakina Torch, Fiona Hemming, Anne Petiot, Jean-Marc Verna, Sandrine Fraboulet, Rémy Sadoul
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 200–203.
Published: 20 January 2009
... described for its capacity to bind to the calcium-binding protein, ALG-2. Alix regulates neuronal death in ways involving interactions with ALG-2 and with proteins of the ESCRT (endosomal sorting complex required for transport). Even though all Alix interactors characterized to date are involved...
Articles
Hironori Suzuki, Masato Kawasaki, Tatsutoshi Inuzuka, Mayumi Okumura, Takeshi Kakiuchi, Hideki Shibata, Soichi Wakatsuki, Masatoshi Maki
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 190–194.
Published: 20 January 2009
... protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein Cell Death Differ. 1999 6 124 129 7 Vito P. Pellegrini L. Guiet C. D'Adamio L. Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1309–1312.
Published: 19 November 2008
...Ilaria Pelizzoni; Romina Macco; Daniele Zacchetti; Fabio Grohovaz; Franca Codazzi Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1046–1048.
Published: 25 October 2007
... The Authors Journal compilation © 2007 Biochemical Society 2007 C2 domain calcium phosphatidylserine polybasic cluster protein kinase C (PKC) PtdIns(4,5) P 2 PKC (protein kinase C) is a large family of phospholipid-dependent serine/threonine kinases, which is activated by many extracellular...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1088–1091.
Published: 25 October 2007
... ). 2 Present address: Department of Biology (Area 9), University of York, PO Box 373, York YO10 5YW, U.K. 20 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcium endocytosis endosome lysosome mucolipin multivesicular body The luminal ionic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 133–135.
Published: 22 January 2007
... 2006 apoptosis calcium cell differentiation cell proliferation prostate cancer transient receptor potential channel (TRP channel) PC (prostate cancer) is one of the leading threats to men's health. Its early stage depends on androgens for growth and survival, and androgen ablation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1356–1361.
Published: 25 October 2006
...R. Simon; Z. Xiong Intracellular calcium toxicity remains the central feature in the pathophysiology of ischaemic cell death in brain. Glutamate-gated channels have been thought to be the major sites of ischaemia-induced toxic calcium entry, but the failure of glutamate antagonists in clinical...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (4): 504–509.
Published: 21 July 2006
... correspondence should be addressed (email [email protected] ). 9 5 2006 © 2006 The Biochemical Society 2006 cAMP phosphodiesterase-4 (PDE4) calcium intracellular targeting membrane insertion memory phosphatidic acid Generation of the ubiquitous second messenger cAMP...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (4): 468–471.
Published: 21 July 2006
... to illustrate the formation of cAMP gradients [ 11 ], to estimate cAMP diffusion rate in invertebrate neurons [ 11 ], to simultaneously monitor the [cAMP] and PKA-mediated regulation of calcium channels in frog ventricular myocytes [ 12 ] and to report dynamic interactions between Ca 2+ transients and cAMP...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (4): 498–501.
Published: 21 July 2006
... To whom correspondence should be addressed (email [email protected] ). 28 3 2006 © 2006 The Biochemical Society 2006 calcium cAMP fluorescein arsenical helix binder (FlAsH) glucagon-like peptide-1 insulin protein kinase A (PKA) Spatial compartmentalization...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (4): 515–517.
Published: 21 July 2006
..., including Ca 2+ and cAMP, that lie downstream of G s is not resolved. 1 To whom correspondence should be addressed (email [email protected] ). 4 5 2006 © 2006 The Biochemical Society 2006 calcium cAMP G-protein inositol 1,4,5-trisphosphate intracellular signalling parathyroid...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 370–373.
Published: 22 May 2006
... degradation), sterol and lipid biosynthesis and calcium sequestration. The last two, as well as apoptosis, are critically regulated by the close association of the SER with mitochondria. Studies with AMFR (autocrine motility factor receptor) have defined an SER domain whose integrity and mitochondrial...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 374–376.
Published: 22 May 2006
... calcium microdomain 5′-nucleotidase raft smooth muscle 5′-Nucleotidase is an enzyme that is linked to the outer lipid layer of the plasma membrane via a GPI (glycosylphosphatidylinositol)–lipid anchor and is separated from the intracellular milieu by the inner layer of the lipid bilayer, while...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (2): 228–231.
Published: 20 March 2006
... in CHF. 1 email [email protected] 14 9 2005 © 2006 The Biochemical Society 2006 calcium cardiac cell gene transcription hypertrophy inositol trisphosphate nuclear factor of activated T-cells (NFAT) Cells express a large number of Ca 2+ signalling...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 939–942.
Published: 01 October 2003
... specifically with changes in electrophysiological properties of cells and intracellular calcium regulation. 1 e-mail: stephen.c.o'[email protected] Calcium Oscillations and the 5th UK Calcium Signalling Conference, a Biochemical Society Focused Meeting held at University of Liverpool, 1–2 May 2003...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 912–915.
Published: 01 October 2003
...D.M.F. Cooper Calcium-sensitive adenylate cyclases provide a key regulatory device for integrating the activities of the two major signalling systems, Ca 2+ and cAMP. Recent experiments have brought us closer to understanding the molecular mechanisms whereby Ca 2+ either stimulates or inhibits...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 950–953.
Published: 01 October 2003
...H.L. Roderick; M.D. Bootman Calcium is a pleiotropic messenger controlling a diverse array of intracellular events from fertilization to cell death. One of the main mechanisms by which intracellular calcium is elevated is through Ins P 3 [Ins(1,4,5) P 3 ]-induced mobilization of calcium from its...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 960–962.
Published: 01 October 2003
... the possibility of positive feedback. 1 To whom correspondence should be addressed (e-mail [email protected] ). Calcium Oscillations and the 5th UK Calcium Signalling Conference, a Biochemical Society Focused Meeting held at University of Liverpool, 1–2 May 2003 2 April 2003 © 2003...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (4): 828–832.
Published: 01 August 2003
... by Ca 2+ -binding proteins, including a group of proteins known as neuronal calcium sensor (NCS) proteins. The NCS family includes NCS-1, visinin-like proteins, recoverins, guanylate cyclase-activating proteins and potassium channel-interacting proteins. Some members of this family, such as recoverin...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (4): 812–815.
Published: 01 August 2002
... proteins regulate small-molecular-mass GTPases, phosphoinositide 3-kinase, TEC family tyrosine kinases and intracellular calcium flux. 1 E-mail [email protected] 15 4 2002 © 2002 Biochemical Society 2002 calcium knockout mice lymphocyte activation BCR, B-cell...
