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1-29 of 29
Keywords: calcium signalling
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Articles
Calcium and Ca 2+ /Calmodulin-dependent kinase II as targets for helminth parasite control
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1743–1751.
Published: 12 November 2018
... generalised review of CaMK enzymes is available [ 1 ]. calcium regulation calcium signalling helminths schistosomes Calcium (Ca 2+ ) functions as a central molecule in signal transduction and is one of the most widely used second messengers in cell signalling [ 1 ]. Ca 2+ signalling...
Articles
A mysterious family of calcium-binding proteins from parasitic worms
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1005–1010.
Published: 15 August 2016
... chlorpromazine DLC dynein light chain TFP trifluoperazine Irish Area Section (Protein Interactions in Biology): Held at National University of Ireland Galway, Ireland, 7-8 December 2015 References 1 Clapham D.E. Calcium signaling Cell 1995 80 259 268 10.1016/0092-8674...
Articles
Regulation of calcium and phosphoinositides at endoplasmic reticulum–membrane junctions
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 467–473.
Published: 11 April 2016
...: calcium signalling and phosphoinositide processing. 1 To whom correspondence should be addressed (email [email protected] ). 7 1 2016 © 2016 Authors; published by Portland Press Limited 2016 Local or global elevations in cytoplasmic calcium concentrations are the trigger for a host...
Articles
Designer small molecules to target calcium signalling
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (3): 417–425.
Published: 01 June 2015
... should be addressed (email [email protected] or [email protected] , [email protected] ) . 12 12 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 adenophostin A calcium signalling cyclic adenosine 5′-diphosphoribose (cADPR) chemical...
Articles
Metabotropic glutamate receptor-mediated cyclic ADP ribose signalling
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (3): 405–409.
Published: 01 June 2015
...-evoked signals, which may instead be mediated by activation of ryanodine receptors (RyRs). A prime candidate for mediating this coupling between I-mGluR activation and RyR opening is cyclic ADP ribose (cADPR) and, indeed, several of these PLC-/IP 3 -independent I-mGluR-evoked calcium signals have now...
Articles
Novel signalling mechanism and clinical applications of sperm-specific PLCζ
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (3): 371–376.
Published: 01 June 2015
[email protected] 23 10 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 calcium signalling fertilization infertility phospholipase C (PLC) phospholipase C zeta (PLCζ) sperm At fertilization in mammals, when a sperm fertilizes an oocyte (egg), it delivers...
Articles
Pulmonary vein sleeve cell excitation–contraction-coupling becomes dysynchronized by spontaneous calcium transients
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (3): 410–416.
Published: 01 June 2015
... © The Authors Journal compilation © 2015 Biochemical Society 2015 atrial fibrillation calcium signalling cardiac arrhythmia lung slice pulmonary vein myocyte Atrial fibrillation (AF) is the most common form of cardiac arrhythmia, with a prevalence of 1%–2% of the general population...
Articles
Differential targeting of cPKC and nPKC decodes and regulates Ca 2+ and lipid signalling
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1538–1542.
Published: 17 November 2014
.... 1 To whom correspondence should be addressed (email [email protected] ). 2 9 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 calcium signalling confocal microscopy fluorescent protein fluorescence resonance energy transfer sensor (FRET sensor...
Articles
Structural organization of signalling to and from IP 3 receptors
Available to PurchaseColin W. Taylor, Stephen C. Tovey, Ana M. Rossi, Cristina I. Lopez Sanjurjo, David L. Prole, Taufiq Rahman
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 63–70.
Published: 23 January 2014
... is likely to be spatially organized. © The Authors Journal compilation © 2014 Biochemical Society 2014 calcium signalling cAMP endoplasmic reticulum inositol 1 4 5-trisphosphate receptor (IP 3 receptor) lysosome ryanodine receptor Thirty years ago, and in the face of a commonly...
Articles
A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1140–1146.
Published: 19 September 2012
... review our current knowledge of the link between LRRK2 and autophagic–lysosomal clearance, including regulation of Ca 2+ -dependent events involving NAADP. 6 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 calcium signalling endolysosome leucine-rich repeat...
Articles
Cellular geography of IP 3 receptors, STIM and Orai: a lesson from secretory epithelial cells
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 108–111.
Published: 19 January 2012
... Research Council and the Wellcome Trust. References 1 Petersen O.H. Tepikin A.V. Polarized calcium signaling in exocrine gland cells Annu. Rev. Physiol. 2008 70 273 299 2 Bolender R.P. Stereological analysis of the guinea pig pancreas. I. Analytical model...
Articles
Morphological and functional aspects of STIM1-dependent assembly and disassembly of store-operated calcium entry complexes
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 112–118.
Published: 19 January 2012
... consists of thinner sections of the cortical ER enriched in STIM1 and devoid of chaperones that appear to be specialized ER compartments dedicated to Ca 2+ signalling. calcium signalling endoplasmic reticulum ion channel Orai store-operated calcium entry (SOCE) stromal interaction molecule (STIM...
Articles
Putative roles for phospholipase Cη enzymes in neuronal Ca 2+ signal modulation
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 282–286.
Published: 19 January 2012
... is able to respond to is likely to be due to differences in cellular localization. Alzheimer's disease calcium signalling neural process neuron phospholipase Cη (PLCη) PLC (phospholipase C) enzymes have pivotal roles in transducing extracellular stimuli into physiological changes. Upon...
Articles
From parathyroid hormone to cytosolic Ca 2+ signals
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 147–152.
Published: 19 January 2012
... and [Ca 2+ ] i that requires co-stimulation of a receptor linked to activation of PLC. PTH, by stimulating delivery of cAMP within the AC6–IP 3 R2 junction, then potentiates the responses to Ins(1,4,5) P 3 . adenylate cyclase calcium signalling cAMP Ins P 3 receptor parathyroid hormone...
Articles
A diversity of SERCA Ca 2+ pump inhibitors
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (3): 789–797.
Published: 20 May 2011
... anticancer drug Ca 2+ -ATPase calcium pump inhibitor calcium signalling sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase (SERCA) For more than 40 years, there has been considerable research into molecules that can affect the activity of one of the most extensively studied membrane protein...
Articles
Tuning sperm chemotaxis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (5): 1270–1274.
Published: 24 September 2010
... 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 calcium signalling chemotaxis fertilization flagellum sea-urchin sperm sperm motility ...
Articles
Self-incompatibility in Papaver : identification of the pollen S -determinant PrpS
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 588–592.
Published: 22 March 2010
.... It is not a typical receptor or receptor-kinase like the Brassica S -determinant [ 33 ], so further work will need to address how PrpS functions in Papaver SI. calcium signalling Papaver pollen programmed cell death S -determinant self-incompatibility ...
Articles
Coupling of the NMDA receptor to neuroprotective and neurodestructive events
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1147–1160.
Published: 19 November 2009
... overexpression [ 54 ]. In addition, studies of mice where CREB and/or CREB family members have been deleted also point to a pro-survival role for CREB in vivo both pre- and post-natally [ 55 , 56 ]. calcium signalling neurodegeneration neuroprotection N -methyl- D -aspartate receptor (NMDAR...
Articles
Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1208–1210.
Published: 25 October 2007
... 2007 Biochemical Society 2007 calcium signalling glucokinase activator insulin release islet cell pancreatic β-cell GK (EC 2.7.1.1; hexokinase IV or D) catalyses the phosphorylation of glucose to glucose 6-phosphate in glucosensitive cells, including pancreatic β-cells [ 1 ]. GK has...
Articles
Plasma-membrane calcium pumps and hereditary deafness
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 913–918.
Published: 25 October 2007
... characteristics of the pumps. 1 To whom correspondence should be addressed (email [email protected] ). 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcium signalling deafness hearing loss plasma-membrane calcium pump CASK calcium...
Articles
Plasma-membrane Ca 2+ pumps: structural diversity as the basis for functional versatility
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 919–922.
Published: 25 October 2007
... in the PMCAs. 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcium pump calcium regulation calcium signalling calmodulin plasma-membrane Ca 2+ -ATPase (PMCA) Ca 2+ is a universal regulator of cellular processes ranging from fertilization...
Articles
TRPC1: a core component of store-operated calcium channels
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 96–100.
Published: 22 January 2007
... and several others have demonstrated that TRPC1 is assembled in a signalling complex with key calcium signalling proteins in functionally specific plasma membrane microdomains. Furthermore, critical interactions between TRPC1 monomers as well as interactions between TRPC1 and other proteins determine...
Articles
Regulation of calcium signalling by adenine-based second messengers
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 109–114.
Published: 22 January 2007
... [email protected] ). 18 8 2006 © 2007 The Biochemical Society 2007 ADP-ribose (ADPR) cyclic ADP-ribose (cADPR) calcium signalling nicotinic acid–adenine dinucleotide phosphate (NAADP) second messenger transient receptor potential melastatin 2 (TRPM2) The first...
Articles
Pro-survival signalling from the NMDA receptor
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 936–938.
Published: 25 October 2006
... glutamate levels, acting on NMDARs, is a primary cause of neuronal death following acute trauma such as stroke, mechanical trauma and seizure [ 1 ]. 1 email [email protected] 2 7 2006 © 2006 The Biochemical Society 2006 apoptosis calcium signalling cAMP-response...
Articles
Redox regulation of the ryanodine receptor/calcium release channel
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 919–921.
Published: 25 October 2006
... sarcoplasmic reticulum calcium signalling reactive oxygen species redox regulation ryanodine receptor sarcoplasmic reticulum thiol modification The RyR (ryanodine receptor) is an intracellular ion channel mediating Ca 2+ release from intracellular stores. Mammals express three RyR...
Articles
Movement of calcium signals and calcium-binding proteins: firewalls, traps and tunnels
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 381–384.
Published: 22 May 2006
... Meeting held at Goodenough College, London, U.K., 15–16 December 2005. Organized and edited by S. Cockcroft (University College London, U.K.) and T. Levine (Institute of Ophthalmology, London, U.K.). Calcium signalling is a mature field with a well-developed methodology and considerable depth...
Articles
Ins(1,4,5)P3-mediated calcium signals and apoptosis: is there a role for Bcl-2?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 958–959.
Published: 01 October 2003
...C.W. Distelhorst; H.L. Roderick In this review we speculate that the anti-apoptotic protein Bcl-2 may regulate calcium signals involved in mediating cell death. Evidence that Ins(1,4,5) P 3 -mediated calcium release from the endoplasmic reticulum triggers apoptosis in response to diverse signals...
Articles
Cardiac calcium signalling
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 930–933.
Published: 01 October 2003
... Oscillations and the 5th UK Calcium Signalling Conference, a Biochemical Society Focused Meeting held at University of Liverpool, 1–2 May 2003 7 April 2003 © 2003 Biochemical Society 2003 calcium signalling cardiac contraction cardiac hypertrophy gene transcription...
Articles
Ca 2+ signalling in stomatal guard cells
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (4): 476–481.
Published: 01 August 2000
... calcium signalling stomata specificity ABA, abscisic acid [Ca 2+ ] cyt , cytosolic free Ca 2+ concentration [Ca 2+ ] ext , external Ca 2+ concentration DAG, diacylglygerol Ins(1,4,5) P 3 R, Ins(1,4,5) P 3 receptor K in , plasma membrane inward-rectifying K + channel PLC, phospholipase...
