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Keywords: cancer
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (5): 2059–2075.
Published: 24 October 2024
.... Mutations in DNMT3A and DNMT3B cause rare Mendelian diseases in humans and are cancer drivers. Mammalian DNMT3 methyltransferase activity is regulated by the non-catalytic region of the proteins which contain multiple chromatin reading domains responsible for DNMT3A and DNMT3B recruitment to the genome...
Articles
Suppression of double-stranded RNA sensing in cancer: molecular mechanisms and therapeutic potential
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (5): 2035–2045.
Published: 02 September 2024
...Addison A. Young; Holly E. Bohlin; Jackson R. Pierce; Kyle A. Cottrell Immunotherapy has emerged as a therapeutic option for many cancers. For some tumors, immune checkpoint inhibitors show great efficacy in promoting anti-tumor immunity. However, not all tumors respond to immunotherapies...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (4): 1703–1713.
Published: 02 August 2024
...Emily T. Chan; Cömert Kural Evading programmed cell death (PCD) is a hallmark of cancer that allows tumor cells to survive and proliferate unchecked. Endocytosis, the process by which cells internalize extracellular materials, has emerged as a key regulator of cell death pathways in cancer. Many...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1489–1502.
Published: 10 June 2024
...Matteo Golo; Peter L. H. Newman; Daryan Kempe; Maté Biro The tumor microenvironment (TME) is a complex and dynamic ecosystem that adjoins the cancer cells within solid tumors and comprises distinct components such as extracellular matrix, stromal and immune cells, blood vessels, and an abundance...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1061–1069.
Published: 02 May 2024
...Russell Spencer-Smith; Deborah K. Morrison The RAF kinases are required for signal transduction through the RAS-RAF-MEK-ERK pathway, and their activity is frequently up-regulated in human cancer and the RASopathy developmental syndromes. Due to their complex activation process, developing drugs...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 693–706.
Published: 17 April 2024
... regulation restrains peroxidation of phospholipids within cellular membranes, thereby impeding ferroptosis execution. Unleashing these metabolic breaks is currently therapeutically explored to sensitize cancers to ferroptosis inducing anti-cancer therapies. Reversely, these natural ferroptotic defense...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 529–538.
Published: 25 March 2024
...Christos Chinopoulos Certain cancer cells within solid tumors experience hypoxia, rendering them incapable of oxidative phosphorylation (OXPHOS). Despite this oxygen deficiency, these cells exhibit biochemical pathway activity that relies on NAD + . This mini-review scrutinizes the persistent...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 241–267.
Published: 28 February 2024
... with transcriptional dysregulation. First, MDM2 is a RING-family E3 ligase and a key regulator of the p53 tumor suppressor. Specifically, MDM2 ubiquitinates p53, triggering its degradation by the proteasome. Consequently, MDM2 up-regulation in cancer can drive tumorigenesis through a decrease in p53. Although MDM2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 89–97.
Published: 05 February 2024
... localization and activity. RhoU and RhoV have been linked to cytoskeletal regulation, cell adhesion, and cell migration. They each exhibit distinct expression patterns during embryonic development and diseases such as cancer metastasis, suggesting they have specialized functions. In this review, we...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 1–13.
Published: 04 January 2024
... by Portland Press Limited on behalf of the Biochemical Society 2024 cancer caveolae clathrin endocytosis signaling ITSNs may regulate the trafficking and signaling of multiple receptors through interaction with Rab GTPases, the largest subfamily of Ras GTPases that regulate all aspects...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (6): 2071–2083.
Published: 13 December 2023
..., especially considering that the technical capacity of increasing and decreasing individual RONS types holds excellent potential for tailoring gas plasmas toward specific applications and disease therapies. Cancer CAP cold physical plasma reactive oxygen species ROS wound healing © 2023...
Articles
Athanasios Papadas, Yun Huang, Alexander Cicala, Yaling Dou, Matteo Fields, Alicia Gibbons, Duncan Hong, Daniel J. Lagal, Victoria Quintana, Alejandro Rizo, Brolyn Zomalan, Fotis Asimakopoulos
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (6): 2017–2028.
Published: 30 November 2023
... cancer diagnoses. However, only a minority of patients derive durable benefit and progress with traditional approaches, such as cancer vaccines, remains unsatisfactory. A key to overcoming these barriers resides with a deeper understanding of tumor antigen presentation and the complex and dynamic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (5): 1881–1895.
Published: 06 October 2023
... tissue development, homeostasis, and wound healing. During cancer progression, the basement membrane is degraded, and proteins typically found in the basement membrane, including peroxidasin and collagen IV, can be found spread throughout the tumour microenvironment where they interact with cancer cells...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (5): 1749–1763.
Published: 18 September 2023
... mutations across diverse cancer types suggest that normal chromatin structure is a barrier to tumorigenesis. Oncohistone mutations disrupt chromatin structure and gene regulatory mechanisms, resulting in aberrant gene expression and the development of cancer phenotypes. Examples of oncohistones include...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1097–1109.
Published: 14 June 2023
... cell states. In particular, we highlight their functions in the development of mammalian limbs, the inner ear, and craniofacial structure while discussing the genetic and biochemical evidence that showcases their conserved roles in tissue regeneration, disease, and cancer pathogenesis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1143–1155.
Published: 12 June 2023
... on the surface of leukocytes and thus plays an additional role in mediating immune cell transmigration across epithelial tissues. Given the importance of both biological processes in cancer, CAR is emerging as a potential mediator of tumorigenesis as well as a target on cancer cells for viral therapy delivery...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 925–936.
Published: 09 June 2023
... and the overexpression of βTrCP observed in various cancers support a potential therapeutic role for inhibitors in the treatment of cancer. A small molecule substituted pyrazolone, GS143, and the natural product erioflorin have been identified as inhibitors of βTrCP and protect its targets from proteasomal degradation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1225–1233.
Published: 04 May 2023
... for this article was enabled by the participation of the University of Geneva in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with Individual. cancer cell cycle cryo-electron microscopy enzyme–substrate interactions...
Articles
Larissa Tinô de Carvalho-Silva, Ana Gabriela C. Normando, Jamile de Oliveira Sá, Erison Santana dos Santos, Tatiane De Rossi, Ariane Fidelis Busso-Lopes, Ana Karina de Oliveira, Adriana F. Paes Leme
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 771–781.
Published: 06 April 2023
...Larissa Tinô de Carvalho-Silva; Ana Gabriela C. Normando; Jamile de Oliveira Sá; Erison Santana dos Santos; Tatiane De Rossi; Ariane Fidelis Busso-Lopes; Ana Karina de Oliveira; Adriana F. Paes Leme Cancer is a significant cause of death, precluding increasing life expectancy worldwide...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 597–612.
Published: 20 March 2023
... response in HCC and might also have validity for predicting responses to immunotherapy in other cancers. In this review, we explore the immunosuppressive mechanisms and interactions of oncofetal cells in the TME of HCC and their potential implications for immunotherapy response. Correspondence: Ankur...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 447–456.
Published: 23 January 2023
... that novel creative ideas continue to be important to exterminate RAS in cancer and other RAS pathway-driven diseases, such as RASopathies. Correspondence: Daniel Abankwa ( [email protected] ) * These authors contributed equally to this work. 30 11 2022 11 1 2023 12 1 2023...
Includes: Supplementary data
Articles
In Collection
Cell death and survival
Francesca Di Cristofano, Andrew George, Vida Tajiknia, Maryam Ghandali, Laura Wu, Yiqun Zhang, Praveen Srinivasan, Jillian Strandberg, Marina Hahn, Ashley Sanchez Sevilla Uruchurtu, Attila A. Seyhan, Benedito A. Carneiro, Lanlan Zhou, Kelsey E. Huntington, Wafik S. El-Deiry
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 57–70.
Published: 11 January 2023
... perspective on translational directions of the field. The evasion of apoptosis was recognized in the late 1980s as a mechanism of cancer development and progression and was included in 2000 among the original key hallmarks of cancer. Since then, much work has been done to pursue the targeted activation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1885–1895.
Published: 13 December 2022
...Aristeidis Panagiotis Sfakianos; Rebecca Mallory Raven; Anne Elizabeth Willis Protein synthesis is dysregulated in the majority of cancers and this process therefore provides a good therapeutic target. Many novel anti-cancer agents are directed to target the initiation stage of translation, however...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1823–1836.
Published: 01 December 2022
...Sharissa L. Latham; Yolande E.I. O'Donnell; David R. Croucher c-Jun N-terminal Kinases (JNKs) have been identified as key disease drivers in a number of pathophysiological settings and central oncogenic signaling nodes in various cancers. Their roles in driving primary tumor growth, positively...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1447–1456.
Published: 25 October 2022
...Katherine L.B. Borden Typically, cancer is thought to arise due to DNA mutations, dysregulated transcription and/or aberrant signalling. Recently, it has become clear that dysregulated mRNA processing, mRNA export and translation also contribute to malignancy. RNA processing events result in major...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1119–1128.
Published: 28 July 2022
...Gaoyuan Wang; Sarah T. Diepstraten; Marco J. Herold BFL-1 is an understudied pro-survival BCL-2 protein. The expression of BFL-1 is reported in many cancers, but it is yet to be clarified whether high transcript expression also always correlates with a pro-survival function. However, recent...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1245–1257.
Published: 17 June 2022
...Ryan Lusby; Philip Dunne; Vijay K. Tiwari Activating invasion and metastasis are one of the primary hallmarks of cancer, the latter representing the leading cause of death in cancer patients. Whilst many advances in this area have been made in recent years, the process of cancer dissemination...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 975–985.
Published: 06 April 2022
...Dana Beiki; Ian M. Eggleston; Charareh Pourzand 5-Aminolevulinic acid-based photodynamic therapy (ALA-PDT) was first implemented over three decades ago and has since been mainly part of clinical practice for the management of pre-cancerous and cancerous skin lesions. Photodynamic therapy relies...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 825–837.
Published: 28 March 2022
...Adithya Balasubramanian; Thomas John; Marie-Liesse Asselin-Labat Evading immune destruction is one of the hallmarks of cancer. A key mechanism of immune evasion deployed by tumour cells is to reduce neoantigen presentation through down-regulation of the antigen presentation machinery. MHC-I and MHC...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 473–485.
Published: 07 February 2022
... sphere formation of Hep3B cells and tumor engraftment frequency of DU145 cells [ 73 ]. These findings underscore the important role of glucose in tumor sphere-forming cells and provide a revolutionized view of NEDD4 as an epigenetic regulator in cancer that deserves further investigations. Finally...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 423–437.
Published: 11 January 2022
... and cancer treatments, defensins uniquely target specific membrane lipids via mechanisms distinct from other HDPs. Therefore, defensins could be potentially developed as therapeutics with increased selectivity and reduced susceptibility to the resistance mechanisms of tumour cells and infectious pathogens...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2727–2736.
Published: 25 November 2021
... integrity. Increasing evidence indicates that chromatin homeostasis plays a key role in the cellular response to TRCs as well as in the preservation of genome integrity. Indeed, chromatin regulating enzymes are frequently mutated in cancer cells, a common characteristic of which is genome instability...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2253–2269.
Published: 28 October 2021
...Shannon R. Tracey; Peter Smyth; Caroline J. Barelle; Christopher J. Scott Interest in nanomedicines has grown rapidly over the past two decades, owing to the promising therapeutic applications they may provide, particularly for the treatment of cancer. Personalised medicine and ‘smart’ actively...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2021–2035.
Published: 08 October 2021
...Marie Sorbara; Nicolas Bery The RAS superfamily of small GTPases regulates major physiological cellular processes. Mutation or deregulation of these small GTPases, their regulators and/or their effectors are associated with many diseases including cancer. Hence, targeting these classes of proteins...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2397–2410.
Published: 28 September 2021
...W. Douglas Fairlie; Erinna F. Lee The deregulation of apoptosis is a key contributor to tumourigenesis as it can lead to the unwanted survival of rogue cells. Drugs known as the BH3-mimetics targeting the pro-survival members of the BCL-2 protein family to induce apoptosis in cancer cells have...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1841–1853.
Published: 02 August 2021
...Ana Sayuri Yamagata; Paula Paccielli Freire Cancer cachexia is associated with deficient response to chemotherapy. On the other hand, the tumors of cachectic patients remarkably express more chemokines and have higher immune infiltration. For immunogenicity, a strong induction of the unfolded...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1425–1442.
Published: 01 July 2021
... GTPases in the context of the membrane. The role of Cdc42 in cancer is well established but the molecular details of its action are still being uncovered. Here we review alterations found to Cdc42 itself and to key components of the signal transduction pathways it controls in cancer. Given the challenges...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1041–1054.
Published: 22 June 2021
... of enhancer function could be the main cause of tissue-specific cancer development. MLL3/KMT2C and MLL4/KMT2D are two paralogous histone modifiers that belong to the SET1/MLL (also named COMPASS) family of lysine methyltransferases and play critical roles in enhancer-regulated gene activation. Importantly...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 675–683.
Published: 16 April 2021
...). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cancer dimerization hippo pathway protein kinases SARAH domain signal transduction In addition to these core signaling elements, various members of the Hippo pathway associate with and are regulated by many...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 843–854.
Published: 11 March 2021
...Joana G. Rodrigues; Henrique O. Duarte; Celso A. Reis; Joana Gomes Aberrant cell surface glycosylation signatures are currently known to actively drive the neoplastic transformation of healthy cells. By disrupting the homeostatic functions of their protein carriers, cancer-associated glycans...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 17–27.
Published: 18 February 2021
... and transcriptional networks. In this way, mitochondria are central to the cell's homeostatic machinery, and as such mitochondrial dysfunction underlies the pathology of a diverse range of diseases including mitochondrial disease and cancer. Mitochondrial import pathways and targeting mechanisms provide the means...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 93–105.
Published: 25 January 2021
... that belongs to the Fe-II dependent dioxygenase family that uses α-ketoglutarate and molecular oxygen as cofactors, is overexpressed in several cancers and is associated with an overall poor prognosis. KDM4A demethylates lysine 9 (H3K9me2/3) and lysine 36 (H3K36me3) methyl marks on histone H3. Given...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 269–280.
Published: 15 January 2021
... response. Given many cancers originate from point mutations in cancer-driving genes, the application of base editing for either modelling tumour development, therapeutic editing, or functional screening is of great promise. In this review, we summarise current DNA base editing technologies and will discuss...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2691–2701.
Published: 26 November 2020
...Atanu Chakraborty Oncogenic mutation in KRAS is one of the most common alterations in human cancer. After decades of extensive research and unsuccessful drug discovery programs, therapeutic targeting of KRAS mutant tumour is at an exciting juncture. The discovery of mutation-specific inhibitors...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2703–2719.
Published: 16 November 2020
... and survival, mainly through activating and directing Rac1 signalling. Dysregulation of the Tiam GEFs is significantly associated with human diseases including cancer, immunological and neurological disorders. Uncovering the mechanisms and consequences of dysregulation is therefore imperative to improving...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 1831–1841.
Published: 01 September 2020
...Mariyam Zuberi; Imran Khan; John P. O'Bryan RAS is a membrane localized small GTPase frequently mutated in human cancer. As such, RAS has been a focal target for developing cancer therapeutics since its discovery nearly four decades ago. However, efforts to directly target RAS have been challenging...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1609–1621.
Published: 14 August 2020
...William A. Flavahan Epigenetic processes converge on chromatin in order to direct a cell's gene expression profile. This includes both maintaining a stable cell identity, but also priming the cell for specific controlled transitions, such as differentiation or response to stimuli. In cancer...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1493–1504.
Published: 11 August 2020
... exhibits a particularly high constitutive activity robustly modulating a wide network of cellular pathways altering the host cell environment to benefit HCMV infection. Several studies suggest that US28-mediated signalling may contribute to cancer progression. In this review, we discuss the unique...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1765–1780.
Published: 29 July 2020
... for structure-based drug design efforts targeting canonical Wnt signalling. beta-catenin cancer crystallography frizzled glycogen synthase kinase Wnt proteins Notum is an extracellular deacetylase that removes O -lipidation from Wnt proteins, thus deactivating them. The structural biology...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1505–1518.
Published: 17 July 2020
... that, in a particular microenvironment, confer mutant lineages a fitness advantage relative to normal somatic cells do occur, and can result in cancer. This minireview highlights several views and paradigms that relate the evolution of multicellularity to cancer. As a phenomenon, cancer is generally understood...
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