... are observed in cardiac hypertrophy and heart failure (HF) that lead to a mismatch in ATP supply and demand, contributing to poor prognosis. A link between Na i and altered metabolism has been proposed but is not well understood. Many mitochondrial enzymes are stimulated by mitochondrial calcium (Ca mito...

... on behalf of the Biochemical Society 2017 cardiac hypertrophy cardiovascular physiology diabetes ischemia myocardium O -GlcNAc The first reports suggesting that the post-translational modification (PTM) of serine and threonine residues of proteins by O -linked N -acetylglucosamine ( O...

... correspondence should be addressed (email [email protected] ). 1 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cardiac hypertrophy chromatin epigenetics histone histone methylation The importance of the epigenome in regulating cardiac...

...A.J. Bingham; L. Ooi; I.C. Wood Cardiac hypertrophy is an increase in the size of cardiac myocytes to generate increased muscle mass, usually driven by increased workload for the heart. Although important during postnatal development and an adaptive response to physical exercise, excessive...

... Oscillations and the 5th UK Calcium Signalling Conference, a Biochemical Society Focused Meeting held at University of Liverpool, 1–2 May 2003 7 April 2003 © 2003 Biochemical Society 2003 calcium signalling cardiac contraction cardiac hypertrophy gene transcription...