... of the Biochemical Society 2024 cardiovascular disease membranes sphingolipids type 2 diabetes Ceramides accrue when de novo synthesis is markedly up-regulated within the ER or when inflammatory cytokine receptors activate sphingomyelinases on the exofacial leaflet of the plasma membrane...

... Press and the Biochemical Society under a transformative agreement with JISC. BMP signalling cardiovascular disease extracellular regulation of signalling molecular mechanisms pulmonary arterial hypertension therapeutics Pulmonary arterial hypertension (PAH) is a rare but debilitating...

...Marina Diotallevi; Faseeha Ayaz; Thomas Nicol; Mark J. Crabtree Inflammation is a critical component of cardiovascular disease (CVD), encompassing coronary artery disease (CAD), cerebrovascular events and heart failure and is the leading cause of mortality worldwide. In recent years, metabolism has...

... by the participation of University of Cambridge in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. cardiovascular disease cell plasticity lineage tracing single cell RNA sequencing vascular smooth muscle Vascular...

... 2021 cardiovascular disease microrna phenotype vascular smooth muscle miR-145 is embedded within this transcriptional network. SRF, myocardin and MRTF-A have all been demonstrated to promote expression of miR-145 in vascular SMC [ 5 , 10 ]. miR-145 itself directly targets KLF4 in human...

... cardiovascular disease, hematologic manifestations, arthritis and in rare cases hepatic failure. Hypercholesterolemia-induced premature cardiovascular disease can manifest as premature coronary heart disease or sudden cardiac death [ 35 ]. Hemolytic anemia, splenomegaly, bleeding disorders...

... on behalf of the Biochemical Society 2018 cardiovascular disease gene therapy high-throughput screening microRNA The foundation of molecular biology states that DNA is copied to RNA by the process of transcription. The transcribed RNA then translates the information to produce proteins...

... TRIB1 locus as being significantly associated with multiple plasma lipid traits and cardiovascular disease (CVD) in humans. The involvement of TRIB1 in hepatic lipid metabolism has been validated through viral-mediated hepatic overexpression of the gene in mice; increasing levels of TRIB1 decreased...

...Sabrina Prudente; Vincenzo Trischitta Insulin resistance is pathogenic for many prevalent disorders including type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), polycystic ovary syndrome, non-alcoholic fatty liver disease, Alzheimer's and Parkinson's diseases and several cancers...

... in vascular homoeostasis, focusing our attention on the importance of the NO pathway alterations in cardiovascular diseases and their relationship to major risk factors. © The Authors Journal compilation © 2014 Biochemical Society 2014 In addition to their central role in regulating vascular...

... with cardiovascular disease, the specific effect of hyper- (or hypo-) glycaemia is less well understood. The present review focuses on the impact that glycaemic dysregulation has on respiratory function and ROS (reactive oxygen species) generation in the endothelial cells that are critical in preventing several key...

...Branka Vulesevic; Ross W. Milne; Erik J. Suuronen Diabetes is a well-known risk factor for the development of cardiovascular diseases. Diabetes affects cardiac tissue through several different, yet interconnected, pathways. Damage to endothelial cells from direct exposure to high blood glucose...

...; it is also a potent survival factor and an upstream regulator of mitochondrial biogenesis. In diabetes and cardiovascular disease, CREB protein content is decreased in the vascular media, and its regulation in aberrant in β-cells, neurons and cardiomyocytes. Loss of CREB content and function leads...

... endothelial cell dysfunction is one of the basic features and early indicators of cardiovascular diseases [ 9 ]. During normal vascular homoeostasis, the healthy endothelium responds to a number of physical and chemical signals, thereby regulating vascular tone, adhesion of circulating cells and smooth muscle...

... ‘protective’ mechanisms of cAMP action will inform the development of the next generation of pharmaceuticals specifically designed to combat endothelial inflammation associated with cardiovascular disease. 1 To whom correspondence should be addressed (email [email protected] ). 11 5...

... of these factors contribute to increased risk of CVD (cardiovascular disease). Since little is known about postprandial dyslipidaemia in overweight children, we sought to compare fasting levels of apoB48 with the HOMA-IR (homoeostasis model assessment of insulin resistance) score, classic lipid profile and VAT...

...J. Striessnig; A. Koschak; M.J. Sinnegger-Brauns; A. Hetzenauer; N.K. Nguyen; P. Busquet; G. Pelster; N. Singewald Voltage-gated LTCCs (L-type Ca 2+ channels) are established drug targets for the treatment of cardiovascular diseases. LTCCs are also expressed outside the cardiovascular system...

... receptor. Transcription of HMG CoA reductase is also upregulated but this enzyme is not sufficiently increased to overcome the drug effect, i.e. there is more inhibition present than the excess enzyme produced. cardiovascular disease cholesterol absorption cholesterol synthesis ezetimibe HMG CoA...

... the potential to accelerate cholesterol deposition in the plaque and to cause plaque disruption, explaining in part the increased cardiovascular disease found in diabetes. 1 e-mail [email protected] Triglyceride-Rich Lipoproteins and Atherosclerosis a meeting of the Biochemical Society's Irish Area...