...John E. Lim; Pascal Bernatchez; Ivan R. Nabi Caveolin-1 (Cav1) is a 22 kDa intracellular protein that is the main protein constituent of bulb-shaped membrane invaginations known as caveolae. Cav1 can be also found in functional non-caveolar structures at the plasma membrane called scaffolds...

... summarizes recent studies on ITSN and provides an overview of the function of this important family of scaffold proteins in various biological processes. cancer caveolae clathrin endocytosis signaling Figure 4. ITSN1 in the regulation of Cbl-mediated EGFR signaling. ITSN1's SH3 domains bind...

... complex mechanisms to respond to these stresses. Here, we briefly summarise current evidence linking caveolae to the cellular oxidative stress response. We discuss recent studies in cultured cells and in an in vivo model suggesting that lipid peroxidation driven by oxidative stress causes disassembly...

...Anne K. Kenworthy The ability of cells to divide, migrate, relay signals, sense mechanical stimuli, and respond to stress all rely on nanoscale invaginations of the plasma membrane known as caveolae. The caveolins, a family of monotopic membrane proteins, form the inner layer of the caveolar coat...

.... Special attention is paid to the way in which cell membrane caveolae and the transverse-axial tubule system allow molecular localisation. We explore the effects of cell maturation, pathology and regional differences in the organisation of these processes. The subject of signal compartmentation has had...

...Michael M. Kessels; Britta Qualmann The formation of caveolae, bulb-shaped plasma membrane invaginations, requires the coordinated action of distinct lipid-interacting and -shaping proteins. The interdependence of caveolar structure and function has evoked substantial scientific interest given...

...Madlen Hubert; Elin Larsson; Richard Lundmark Caveolae are small Ω-shaped invaginations of the plasma membrane that play important roles in mechanosensing, lipid homeostasis and signaling. Their typical morphology is characterized by a membrane funnel connecting a spherical bulb to the membrane...

.... This review will focus on the relationship of a particular membrane microdomain — caveolae — with mitochondria and the particular implication of this to physiology and pathophysiology. Correspondence: Hemal H. Patel ( [email protected] ) 21 11 2019 9 1 2020 10 1 2020 © 2020 The Author...

...Kyle T. Root; Jeffrey A. Julien; Kerney Jebrell Glover Caveolae are 50–100 nm invaginations found within the plasma membrane of cells. Caveolae are involved in many processes that are essential for homeostasis, most notably endocytosis, mechano-protection, and signal transduction. Within...

... of its local lipid environment can potentially influence cadherin signalling, adhesion and dynamics, focusing on a role for phosphoinositide-4,5-bisphosphate. Secondly, we discuss how caveolae may indirectly regulate cadherins by modifying either the lipid composition and/or mechanical tension...

...E. Ikonen; S. Heino; S. Lusa Caveolae (small plasma membrane invaginations) and their coat proteins, caveolins, have attracted the attention of researchers in diverse fields, including cell biology, cardiovascular and cancer research. The tight association between caveolin and cholesterol governs...

... is enforced by the placement of Ca 2+ -sensitive adenylate cyclases (AC5, AC6 and AC8) in caveolae, from which at least one Ca 2+ -insensitive adenylate cyclase (AC7) is excluded. However, additional protein–protein interactions are also required to ensure the dependency of these cyclases on capacitative Ca 2...

...B. Razani; A. Schlegel; J. Liu; M. P. Lisanti Caveolae (‘little caves’) are plasma membrane specializations of 50–100 nm in diameter, and the caveolins are structural proteins used by cells to form caveolae. We and other investigators have discovered that caveolae organelles may be important both...

...M. G. Waugh; S. Minogue; J. S. Anderson; M. dos Santos; J. J. Hsuan Rafts are small membrane domains containing discrete subsets of lipids and proteins. Although microscopic raft structures termed ‘caveolae’ were described nearly 50 years ago, the importance of rafts, particularly signalling within...