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Keywords: cell culture
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Biochem Soc Trans (2013) 41 (3): 711–719.
Published: 23 May 2013
... a regulatory interphase between the genetic information and the environment. Cell culture systems provide a useful model to study epigenetic processes, including the effect of the environment. Cultured pluripotent stem cell lines are often used as an in vitro surrogate system to investigate molecular...
Biochem Soc Trans (2010) 38 (4): 1033–1036.
Published: 26 July 2010
... scalable and high-fidelity human hepatocytes from hepatic cell lines and fetal and adult progenitors have been limited organ availability, homogeneous cell purification, short-term cell culture, and the rapid loss of hepatocyte phenotype and function in culture. Therefore it has been necessary to find...
Biochem Soc Trans (2010) 38 (4): 1072–1075.
Published: 26 July 2010
...Daniel J. Maltman; Stefan A. Przyborski Drug discovery programmes require accurate in vitro systems for drug screening and testing. Traditional cell culture makes use of 2D (two-dimensional) surfaces for ex vivo cell growth. In such environments, cells are forced to adopt unnatural characteristics...
Biochem Soc Trans (2009) 37 (4): 660–664.
Published: 22 July 2009
... had a direct effect on the gelation time, mechanical properties and molecular arrangements as determined through oscillatory rheology, fluorescence spectroscopy and CD spectroscopy. This highly tuneable cost-effective gel system may have applications in three-dimensional cell culture. The molecular...
Biochem Soc Trans (2007) 35 (5): 1147–1150.
Published: 25 October 2007
...B. Halliwell The terms ‘antioxidant’, ‘oxidative stress’ and ‘oxidative damage’ are widely used but rarely defined. This brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using...