Page 1 | Search Results | Biochemical Society Transactions

1-50 of 57

Sort by

Sort Order Select

Articles

Cdk activation by phosphorylation: linking growth signals to cell cycle control

Heidi M. Blank, Eun-Gyu No, Michael Polymenis

Biochem Soc Trans (2025) BST20253004.

https://doi.org/10.1042/BST20253004

Published: 09 May 2025

...Heidi M. Blank; Eun-Gyu No; Michael Polymenis Cells adjust their proliferation in response to extrinsic factors and nutrients. Such inputs must reach the cell cycle machinery to ensure proper cell proliferation. This minireview focuses on evidence suggesting that phosphorylating the T-loop domain...

View articletitled, Cdk activation by phosphorylation: linking growth signals to cell cycle control

Articles

Same same but different? How blood and lymphatic vessels induce cell contact inhibition

Claudia Carlantoni, Leon M.H. Liekfeld, Manu Beerens, Maike Frye

Biochem Soc Trans (2025) 53 (01): 181–191.

https://doi.org/10.1042/BST20240573

Published: 06 February 2025

... Attribution License 4.0 (CC BY) . Many studies highlight the importance of cell adhesion molecules in the establishment of contact inhibition. For example, in epithelial carcinoma cells, E-cadherin controls an increase in expression of the CDKN1 protein p27 to trigger cell cycle arrest [ 4 ]. Notably...

View articletitled, Same same but different? How blood and lymphatic vessels induce cell contact inhibition

Articles

Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases

Derek L. Bolhuis, Michael J. Emanuele, Nicholas G. Brown

Biochem Soc Trans (2024) 52 (1): 241–267.

https://doi.org/10.1042/BST20230454

Published: 28 February 2024

... interactions and focus on their relationships. cancer cell cycle deubiquitinase E3 ubiquitin ligase post-translational modification ubiquitin Correspondence: Michael J. Emanuele ( [email protected] ) or Nicholas G. Brown ( [email protected] ) 19 12 2023 31 1 2024 6...

View articletitled, Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases

Articles

The molecular mechanisms of human separase regulation

Jun Yu, David O. Morgan, Andreas Boland

Biochem Soc Trans (2023) 51 (3): 1225–1233.

https://doi.org/10.1042/BST20221400

Published: 04 May 2023

... of the latest discoveries for ordered cell cycle progression. Structural studies of the separase protease domain fused to a substrate-mimicking peptide [ 31 ], as well as multiple studies of full-length separase bound to the inhibitory pseudosubstrate securin [ 30 , 32 , 33 ], have provided important...

View articletitled, The molecular mechanisms of human separase regulation

Articles

Processing DNA lesions during mitosis to prevent genomic instability

Anastasia Audrey, Lauren de Haan, Marcel A.T.M. van Vugt, H. Rudolf de Boer

Biochem Soc Trans (2022) 50 (4): 1105–1118.

https://doi.org/10.1042/BST20220049

Published: 30 August 2022

...Anastasia Audrey; Lauren de Haan; Marcel A.T.M. van Vugt; H. Rudolf de Boer Failure of cells to process toxic double-strand breaks (DSBs) constitutes a major intrinsic source of genome instability, a hallmark of cancer. In contrast with interphase of the cell cycle, canonical repair pathways...

View articletitled, Processing DNA lesions during mitosis to prevent genomic instability

Articles

CDK activity sensors: genetically encoded ratiometric biosensors for live analysis of the cell cycle

Michael A. Q. Martinez, David Q. Matus

Biochem Soc Trans (2022) 50 (3): 1081–1090.

https://doi.org/10.1042/BST20211131

Published: 08 June 2022

...Michael A. Q. Martinez; David Q. Matus Cyclin-dependent kinase (CDK) sensors have facilitated investigations of the cell cycle in living cells. These genetically encoded fluorescent biosensors change their subcellular location upon activation of CDKs. Activation is primarily regulated...

View articletitled, CDK activity sensors: genetically encoded ratiometric biosensors for live analysis of the cell cycle

Articles

PIDD1 in cell cycle control, sterile inflammation and cell death

In Collection

Cell death and survival

Elias S. Weiler, Tamas G. Szabo, Irmina Garcia-Carpio, Andreas Villunger

Biochem Soc Trans (2022) 50 (2): 813–824.

https://doi.org/10.1042/BST20211186

Published: 28 March 2022

...Elias S. Weiler; Tamas G. Szabo; Irmina Garcia-Carpio; Andreas Villunger The death fold domain-containing protein PIDD1 has recently attracted renewed attention as a regulator of the orphan cell death-related protease, Caspase-2. Caspase-2 can activate p53 to promote cell cycle arrest in response...

View articletitled, PIDD1 in cell cycle control, sterile inflammation and cell death

Articles

Efficiency and equity in origin licensing to ensure complete DNA replication

Liu Mei, Jeanette Gowen Cook

Biochem Soc Trans (2021) 49 (5): 2133–2141.

https://doi.org/10.1042/BST20210161

Published: 21 September 2021

...Liu Mei; Jeanette Gowen Cook The cell division cycle must be strictly regulated during both development and adult maintenance, and efficient and well-controlled DNA replication is a key event in the cell cycle. DNA replication origins are prepared in G1 phase of the cell cycle in a process known...

View articletitled, Efficiency and equity in origin licensing to ensure complete DNA replication

Articles

Primary cilia and the DNA damage response: linking a cellular antenna and nuclear signals

Ciaran G. Morrison

Biochem Soc Trans (2021) 49 (2): 829–841.

https://doi.org/10.1042/BST20200751

Published: 12 April 2021

...Ciaran G. Morrison The maintenance of genome stability involves integrated biochemical activities that detect DNA damage or incomplete replication, delay the cell cycle, and direct DNA repair activities on the affected chromatin. These processes, collectively termed the DNA damage response (DDR...

View articletitled, Primary cilia and the DNA damage response: linking a cellular antenna and nuclear signals

Articles

The Golgi ribbon: mechanisms of maintenance and disassembly during the cell cycle

Inmaculada Ayala, Fabiola Mascanzoni, Antonino Colanzi

Biochem Soc Trans (2020) 48 (1): 245–256.

https://doi.org/10.1042/BST20190646

Published: 03 February 2020

... on behalf of the Biochemical Society 2020 cell cycle Golgi apparatus mitosis The Golgi complex (GC) has a central role in the transport, processing, and targeting of lipids and proteins to their final destinations [ 1 ]. The basic transport function does not require a specific structural...

View articletitled, The Golgi ribbon: mechanisms of maintenance and disassembly during the cell cycle

Articles

Cell cycle-dependent phosphorylation and regulation of cellular differentiation

Laura J.A. Hardwick, Roberta Azzarelli, Anna Philpott

Biochem Soc Trans (2018) 46 (5): 1083–1091.

https://doi.org/10.1042/BST20180276

Published: 21 September 2018

...Laura J.A. Hardwick; Roberta Azzarelli; Anna Philpott Embryogenesis requires an exquisite regulation of cell proliferation, cell cycle withdrawal and differentiation into a massively diverse range of cells at the correct time and place. Stem cells also remain to varying extents in different adult...

View articletitled, Cell cycle-dependent phosphorylation and regulation of cellular differentiation

Articles

Regulation of the meiotic divisions of mammalian oocytes and eggs

In Collection

Embryonic development

Jessica R. Sanders, Keith T. Jones

Biochem Soc Trans (2018) 46 (4): 797–806.

https://doi.org/10.1042/BST20170493

Published: 22 June 2018

... for recruiting SAC-related proteins such as Mad1 [ 51 ]. It is unclear whether the KMN network plays a role in monitoring kinetochore–microtubule attachments during meiosis; however, Ndc80 levels at microtubules increase during oocyte maturation and overexpression of Ndc80 causes cell cycle arrest in oocytes...

View articletitled, Regulation of the meiotic divisions of mammalian oocytes and eggs

Articles

Regulation of the cell cycle and centrosome biology by deubiquitylases

Sarah Darling, Andrew B. Fielding, Dorota Sabat-Pośpiech, Ian A. Prior, Judy M. Coulson

Biochem Soc Trans (2017) 45 (5): 1125–1136.

https://doi.org/10.1042/BST20170087

Published: 12 September 2017

.... As potentially druggable enzymes, disease-associated DUBs are of increasing interest as pharmaceutical targets. The biology, structure and regulation of DUBs have been extensively reviewed elsewhere, so here we focus specifically on roles of DUBs in regulating cell cycle processes in mammalian cells. Over...

View articletitled, Regulation of the cell cycle and centrosome biology by deubiquitylases

Articles

The sweet side of the cell cycle

Ee Phie Tan, Francesca E. Duncan, Chad Slawson

Biochem Soc Trans (2017) 45 (2): 313–322.

https://doi.org/10.1042/BST20160145

Published: 13 April 2017

...Ee Phie Tan; Francesca E. Duncan; Chad Slawson Cell division (mitosis) and gamete production (meiosis) are fundamental requirements for normal organismal development. The mammalian cell cycle is tightly regulated by different checkpoints ensuring complete and precise chromosomal segregation...

View articletitled, The sweet side of the cell cycle

Articles

EML proteins in microtubule regulation and human disease

Andrew M. Fry, Laura O'Regan, Jessica Montgomery, Rozita Adib, Richard Bayliss

Biochem Soc Trans (2016) 44 (5): 1281–1288.

https://doi.org/10.1042/BST20160125

Published: 19 October 2016

..., including the body wall, muscles and intestine [ 16 ]. cell cycle EMAP EML MAP microtubule oncogenic fusion Correspondence: Andrew M. Fry ( [email protected] ) 23 5 2016 14 6 2016 15 6 2016 © 2016 The Author(s); published by Portland Press Limited on behalf...

View articletitled, EML proteins in microtubule regulation and human disease

Articles

Regulation of the cytokinesis cleavage furrow by PKCε

Nicola Brownlow, Tanya Pike, Victoria Crossland, Jeroen Claus, Peter Parker

Biochem Soc Trans (2014) 42 (6): 1534–1537.

https://doi.org/10.1042/BST20140240

Published: 17 November 2014

...Nicola Brownlow; Tanya Pike; Victoria Crossland; Jeroen Claus; Peter Parker Cytokinesis is the final act of the cell cycle where the replicated DNA and cellular contents are finally split into two daughter cells. This process is very tightly controlled as DNA segregation errors and cytokinesis...

View articletitled, Regulation of the cytokinesis cleavage furrow by PKCε

Articles

Protein kinase C involvement in cell cycle modulation

Alessandro Poli, Sara Mongiorgi, Lucio Cocco, Matilde Y. Follo

Biochem Soc Trans (2014) 42 (5): 1471–1476.

https://doi.org/10.1042/BST20140128

Published: 18 September 2014

...Alessandro Poli; Sara Mongiorgi; Lucio Cocco; Matilde Y. Follo Protein kinases C (PKCs) are a family of serine/threonine kinases which act as key regulators in cell cycle progression and differentiation. Studies of the involvement of PKCs in cell proliferation showed that their role is dependent...

View articletitled, Protein kinase C involvement in cell cycle modulation

Articles

Acute kidney injury: a paradigm for miRNA regulation of the cell cycle

Usman Khalid, Timothy Bowen, Donald J. Fraser, Robert H. Jenkins

Biochem Soc Trans (2014) 42 (4): 1219–1223.

https://doi.org/10.1042/BST20140093

Published: 11 August 2014

... transplantation, or drug toxicity, has a high morbidity and mortality rate and presents a significant burden to health services worldwide. AKI primarily affects the renal cortex, in particular PTCs (proximal tubular epithelial cells). Current research demonstrates causality between G 2 /M cell cycle arrest...

View articletitled, Acute kidney injury: a paradigm for miRNA regulation of the cell cycle

Articles

NF-κB and the cell cycle

Adeline C. Ledoux, Neil D. Perkins

Biochem Soc Trans (2014) 42 (1): 76–81.

https://doi.org/10.1042/BST20130156

Published: 23 January 2014

... that an important component of NF-κB's function includes regulation of the cell cycle. However, this aspect of its behaviour is often overlooked and receives less attention than its ability to induce inflammatory gene expression. In the present article, we provide an updated review of the current state of our...

View articletitled, NF-κB and the cell cycle

Articles

GCN2, an old dog with new tricks

Beáta Grallert, Erik Boye

Biochem Soc Trans (2013) 41 (6): 1687–1691.

https://doi.org/10.1042/BST20130210

Published: 20 November 2013

... [email protected] ). 3 9 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cancer cell cycle eukaryotic initiation factor 2α (eIF2α) phosphorylation Gcn2 translational regulation Gcn2 was first described in budding yeast as a serine/threonine...

View articletitled, GCN2, an old dog with new tricks

Articles

The programme of DNA replication: beyond genome duplication

Blanca Gómez-Escoda, Pei-Yun Jenny Wu

Biochem Soc Trans (2013) 41 (6): 1720–1725.

https://doi.org/10.1042/BST20130209

Published: 20 November 2013

... programmes have evolved to support different processes, then this may place additional constraints on the plasticity of origin usage. cell cycle development DNA replication origin of replication replication stress S-phase Genome duplication is an essential biological process that is tightly...

View articletitled, The programme of DNA replication: beyond genome duplication

Articles

Structural characterization of the cyclin-dependent protein kinase family

Jane A. Endicott, Martin E.M. Noble

Biochem Soc Trans (2013) 41 (4): 1008–1016.

https://doi.org/10.1042/BST20130097

Published: 18 July 2013

.... cell cycle cyclin cyclin-dependent kinase (CDK) phosphorylation transcription X-ray crystallography It was Louise Johnson who first drew an analogy between protein kinase families and human families, rewriting the opening lines of Leo Tolstoy's Anna Karenina to state that “active protein...

View articletitled, Structural characterization of the cyclin-dependent protein kinase family

Articles

CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy now

Aoife O’Shaughnessy, Brian Hendrich

Biochem Soc Trans (2013) 41 (3): 777–782.

https://doi.org/10.1042/BST20130027

Published: 23 May 2013

... in the DNA-damage response and in cell cycle progression through S-phase and into G 2 . Furthermore, as part of NuRD, it participates in regulating acetylation levels of p53, thereby indirectly regulating the G 1 /S cell cycle checkpoint. Although CHD4 has a somewhat complicated relationship with the cell...

View articletitled, CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy now

Articles

UPF1 involvement in nuclear functions

Wazeer Varsally, Saverio Brogna

Biochem Soc Trans (2012) 40 (4): 778–783.

https://doi.org/10.1042/BST20120052

Published: 20 July 2012

... rapid destruction of mRNAs carrying a PTC (premature translation termination codon). However, some studies have indicated that in human cells UPF1 has additional roles, possibly unrelated to NMD, which are carried out in the nucleus. These might involve telomere maintenance, cell cycle progression...

View articletitled, UPF1 involvement in nuclear functions

Articles

The control of histone gene expression

Alexander M.J. Rattray, Berndt Müller

Biochem Soc Trans (2012) 40 (4): 880–885.

https://doi.org/10.1042/BST20120065

Published: 20 July 2012

...Alexander M.J. Rattray; Berndt Müller Histone proteins are essential for the packaging of DNA into chromosomes. Histone gene expression is cell-cycle-regulated and coupled to DNA replication. Control of histone gene expression occurs at the transcriptional and post-transcriptional level and ensures...

View articletitled, The control of histone gene expression

Articles

Nuclear envelope influences on cell-cycle progression

Vlastimil Srsen, Nadia Korfali, Eric C. Schirmer

Biochem Soc Trans (2011) 39 (6): 1742–1746.

https://doi.org/10.1042/BST20110656

Published: 21 November 2011

... and for the cytoskeleton on its cytoplasmic surface. Both sets of anchors are proteins called NETs (nuclear envelope transmembrane proteins), embedded respectively in the inner or outer nuclear membranes. Several lines of evidence indicate that the nuclear envelope contributes to cell-cycle regulation. These contributions...

View articletitled, Nuclear envelope influences on cell-cycle progression

Articles

Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase

Vasundhara M. Navadgi-Patil, Peter M. Burgers

Biochem Soc Trans (2011) 39 (2): 600–605.

https://doi.org/10.1042/BST0390600

Published: 22 March 2011

... employment differs between these two phases of the cell cycle. The Ddc1 (human Rad9) subunit of the clamp directly activates Mec1 in G 1 -phase, an activity identified only in S. cerevisiae so far. However, in G 2 -phase, the 9-1-1 clamp activates the checkpoint by two mechanisms. One mechanism includes...

View articletitled, Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase

Articles

Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling

Melanie J. Welham, Emmajayne Kingham, Yolanda Sanchez-Ripoll, Benjamin Kumpfmueller, Michael Storm, Heather Bone

Biochem Soc Trans (2011) 39 (2): 674–678.

https://doi.org/10.1042/BST0390674

Published: 22 March 2011

... Journal compilation © 2011 Biochemical Society 2011 cell cycle embryonic stem cell glycogen synthase kinase 3 (GSK-3) phosphoinositide 3-kinase (PI3K) pluripotency proliferation self-renewal ESCs are derived from early pre-implantation embryos and, when cultured appropriately, can...

View articletitled, Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling

Articles

Systems-level feedback in cell-cycle control

Béla Novák, P.K. Vinod, Paula Freire, Orsolya Kapuy

Biochem Soc Trans (2010) 38 (5): 1242–1246.

https://doi.org/10.1042/BST0381242

Published: 24 September 2010

...Béla Novák; P.K. Vinod; Paula Freire; Orsolya Kapuy Alternation of chromosome replication and segregation is essential for successful completion of the cell cycle and it requires an oscillation of Cdk1 (cyclin-dependent kinase 1)–CycB (cyclin B) activity. In the present review, we illustrate...

View articletitled, Systems-level feedback in cell-cycle control

Articles

Life after meiosis: patterning the angiosperm male gametophyte

Michael Borg, David Twell

Biochem Soc Trans (2010) 38 (2): 577–582.

https://doi.org/10.1042/BST0380577

Published: 22 March 2010

... determination, cell-cycle progression and gene regulation. The present mini-review encompasses key advances in our understanding of the molecular mechanisms controlling male gametophyte patterning in angiosperms. A brief overview of male gametophyte development is presented, followed by a discussion...

View articletitled, Life after meiosis: patterning the angiosperm male gametophyte

Articles

Searching for the boundaries: unlimited expansion of ubiquitin and ubiquitin-like signals in multiple cellular functions

Bernat Crosas, Rosa Farràs, Gemma Marfany, Manuel S. Rodríguez, Timothy M. Thomson

Biochem Soc Trans (2010) 38 (1): 1–5.

https://doi.org/10.1042/BST0380001

Published: 19 January 2010

... facilitating APC/C ubiquitylation and proteasome degradation. anaphase-promoting complex/cyclosome (APC/C) cell cycle DNA-damage repair proteasome small ubiquitin-related modifier (SUMO) ubiquitin Acquisition of complexity of the proteasome during evolution can be delineated...

View articletitled, Searching for the boundaries: unlimited expansion of ubiquitin and ubiquitin-like signals in multiple cellular functions

Articles

Fifteen years of APC/cyclosome: a short and impressive biography

Kobi J. Simpson-Lavy, Yifat S. Oren, Oren Feine, Julia Sajman, Tammy Listovsky, Michael Brandeis

Biochem Soc Trans (2010) 38 (1): 78–82.

https://doi.org/10.1042/BST0380078

Published: 19 January 2010

... should be addressed (email [email protected] ). 6 11 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 anaphase-promoting complex/cyclosome (APC/C) cell cycle degron mitotic switch ubiquitination ubiquitin ligase The discovery of the mitotic...

View articletitled, Fifteen years of APC/cyclosome: a short and impressive biography

Articles

miRNPs: versatile regulators of gene expression in vertebrate cells

Joan A. Steitz, Shobha Vasudevan

Biochem Soc Trans (2009) 37 (5): 931–935.

https://doi.org/10.1042/BST0370931

Published: 21 September 2009

... as a function of the cell cycle. The activating role of miRNAs is now being confirmed in the immature Xenopus oocyte, which mimics the quiescent state. Argonaute 2 (AGO2) cell cycle Fragile X mental retardation-related protein 1 (FXR1) microribonucleoprotein (miRNP) quiescence translational activation...

View articletitled, miRNPs: versatile regulators of gene expression in vertebrate cells

Articles

Regulation of Cdc45 in the cell cycle and after DNA damage

Ronan Broderick, Heinz-Peter Nasheuer

Biochem Soc Trans (2009) 37 (4): 926–930.

https://doi.org/10.1042/BST0370926

Published: 22 July 2009

... 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 Cdc45 cell cycle checkpoint DNA damage DNA replication genome stability In all organisms, including humans, accurate chromosomal DNA replication is essential to maintain stability of the genome...

View articletitled, Regulation of Cdc45 in the cell cycle and after DNA damage

Articles

The DNA-damage response: new molecular insights and new approaches to cancer therapy

Stephen P. Jackson

Biochem Soc Trans (2009) 37 (3): 483–494.

https://doi.org/10.1042/BST0370483

Published: 20 May 2009

... laboratory's recent work, which has revealed that the way cells respond to DSBs is modulated in a cell-cycle-dependent manner to ensure that the cell uses the DSB repair system that is most suited to its cell-cycle stage. Finally, I explain how our increasing knowledge of the DDR is suggesting new avenues...

View articletitled, The DNA-damage response: new molecular insights and new approaches to cancer therapy

Articles

Regulation and function of JunB in cell proliferation

Marc Piechaczyk, Rosa Farràs

Biochem Soc Trans (2008) 36 (5): 864–867.

https://doi.org/10.1042/BST0360864

Published: 19 September 2008

...Marc Piechaczyk; Rosa Farràs JunB is a member of the AP-1 (activator protein-1) family of dimeric transcription factors. It exerts a dual action on the cell cycle. It is best known as a cell proliferation inhibitor, a senescence inducer and a tumour suppressor. As for the molecular mechanisms...

View articletitled, Regulation and function of JunB in cell proliferation

Articles

An overview of the fission yeast septation initiation network (SIN)

Andrea Krapp, Viesturs Simanis

Biochem Soc Trans (2008) 36 (3): 411–415.

https://doi.org/10.1042/BST0360411

Published: 21 May 2008

...Andrea Krapp; Viesturs Simanis The fission yeast septation initiation network, or SIN, is a signal transduction network that is required for septum formation in Schizosaccharomyces pombe . Its activity is tightly regulated through the cell cycle, to ensure proper co-ordination of mitosis...

View articletitled, An overview of the fission yeast septation initiation network (SIN)

Articles

Regulation of gene expression by the RNA-binding protein Sam68 in cancer

Prabhakar Rajan, Luke Gaughan, Caroline Dalgliesh, Amira El-Sherif, Craig N. Robson, Hing Y. Leung, David J. Elliott

Biochem Soc Trans (2008) 36 (3): 505–507.

https://doi.org/10.1042/BST0360505

Published: 21 May 2008

... in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer...

View articletitled, Regulation of gene expression by the RNA-binding protein Sam68 in cancer

Articles

Role played by BRCA1 in transcriptional regulation in response to therapy

M.M. Murray, P.B. Mullan, D.P. Harkin

Biochem Soc Trans (2007) 35 (5): 1342–1346.

https://doi.org/10.1042/BST0351342

Published: 25 October 2007

...M.M. Murray; P.B. Mullan; D.P. Harkin BRCA1 (breast-cancer susceptibility gene 1) is a tumour suppressor, implicated in the hereditary predisposition to breast and ovarian cancer. BRCA1 has been implicated in a number of cellular processes including DNA repair and recombination, cell cycle...

View articletitled, Role played by BRCA1 in transcriptional regulation in response to therapy

Articles

Potassium channel blockers quinidine and caesium halt cell proliferation in C6 glioma cells via a polyamine-dependent mechanism

T.M. Weiger, S. Colombatto, V. Kainz, W. Heidegger, M.A. Grillo, A. Hermann

Biochem Soc Trans (2007) 35 (2): 391–395.

https://doi.org/10.1042/BST0350391

Published: 20 March 2007

... of the cell cycle. We investigated the effect of quinidine and caesium (Cs + ) on cell proliferation, LDH (lactate dehydrogenase) release, free internal calcium, membrane potential, polyamine concentration, ODC (ornithine decarboxylase) activity and polyamine uptake in C6 glioma cells. The EC 50 for reducing...

View articletitled, Potassium channel blockers quinidine and caesium halt cell proliferation in C6 glioma cells via a polyamine-dependent mechanism

Articles

A cascade involving p85, Cdc42 and septin 2 regulates cytokinesis

V. Silió, M. Marqués, I. Cortés, S. Zuluaga, A.C. Carrera

Biochem Soc Trans (2007) 35 (2): 222–224.

https://doi.org/10.1042/BST0350222

Published: 20 March 2007

... 1645 1669 15 Belenguer P. Pelloquin L. Baldin V. Oustrin M.L. Ducommun B. Prog. Cell Cycle Res. 1995 1 207 214 16 Hirota T. Morisaki T. Nishiyama Y. Marumoto T. Tada K. Hara T. Masuko N. Inagaki M. Hatakeyama K. Saya H...

View articletitled, A cascade involving p85, Cdc42 and septin 2 regulates cytokinesis

Articles

Inhibition of cell proliferation and induction of apoptosis by N 1 , N 11 -diethylnorspermine-induced polyamine pool reduction

S.M. Oredsson, K. Alm, E. Dahlberg, C.M. Holst, V.M. Johansson, L. Myhre, E. Söderstjerna

Biochem Soc Trans (2007) 35 (2): 405–409.

https://doi.org/10.1042/BST0350405

Published: 20 March 2007

... in DENSPM-treated cells in relation to effects on cell cycle kinetics and induction of apoptosis. To really understand the role of polyamines in cell cycle regulation and apoptosis, we believe it is now time to go through the vast polyamine literature in a meta-analysis-based manner. This short review does...

View articletitled, Inhibition of cell proliferation and induction of apoptosis by N 1 , N 11 -diethylnorspermine-induced polyamine pool reduction

Articles

Is COX-2 a ‘collateral’ target in cancer prevention?

K. Kashfi, B. Rigas

Biochem Soc Trans (2005) 33 (4): 724–727.

https://doi.org/10.1042/BST0330724

Published: 01 August 2005

... should be addressed (email [email protected] ). 22 3 2005 © 2005 The Biochemical Society 2005 apoptosis carbonic anhydrase cell cycle coxib cytochrome c NAG-1 (non-steroidal anti-inflammatory drug-activated gene) Cancer prevention, at present a better option than...

View articletitled, Is COX-2 a ‘collateral’ target in cancer prevention?

Articles

Function and regulation of RhoE

K. Riento, P. Villalonga, R. Garg, A. Ridley

Biochem Soc Trans (2005) 33 (4): 649–651.

https://doi.org/10.1042/BST0330649

Published: 01 August 2005

..., leading to an increase in RhoE levels. In addition, phosphorylation reduces its association with membranes and correlates with its ability to induce loss of stress fibres. RhoE also acts independently of ROCK to inhibit cell cycle progression, in part by preventing translation of cyclin D 1...

View articletitled, Function and regulation of RhoE

Articles

Expression of an RNAi-resistant SLBP restores proper S-phase progression

E.J. Wagner, A. Berkow, W.F. Marzluff

Biochem Soc Trans (2005) 33 (3): 471–473.

https://doi.org/10.1042/BST0330471

Published: 01 June 2005

...-ordinately regulated and mutually dependent on each other [ 1 ]. The cell-cycle regulation of histone protein production is achieved by regulating the steady-state levels of histone mRNA. Metazoan histone mRNAs are the only eukaryotic mRNAs that do not end in a polyadenylated tail, but end...

View articletitled, Expression of an RNAi-resistant SLBP restores proper S-phase progression

Articles

Glucose modulation of cell size in yeast

M. Vanoni, R.L. Rossi, L. Querin, V. Zinzalla, L. Alberghina

Biochem Soc Trans (2005) 33 (1): 294–296.

https://doi.org/10.1042/BST0330294

Published: 01 February 2005

... physiological relevance, since it allows us to coordinate cell growth with cell cycle progression and it is responsible for cell size homeostasis. The cell sizer mechanism requires the overcoming of two sequential thresholds, involving Cln3 and Far1, and Clb5,6 and Sic1, respectively. When both thresholds...

View articletitled, Glucose modulation of cell size in yeast

Articles

Vitamin A regulates proliferation and apoptosis of human T- and B-cells

H.K. Blomhoff

Biochem Soc Trans (2004) 32 (6): 982–984.

https://doi.org/10.1042/BST0320982

Published: 26 October 2004

... that the proliferation of B-cells was inhibited by retinoids, and that this was due to rapid inhibition of the cell cycle machinery regulating G 1 -to-S transition. In contrast, the proliferation of T-cells was enhanced by physiological levels of retinoic acid, and the effect was due to induction of IL-2 (interleukin 2...

View articletitled, Vitamin A regulates proliferation and apoptosis of human T- and B-cells

Articles

Cell cycle-regulated transcription in fission yeast

C.J. McInerny

Biochem Soc Trans (2004) 32 (6): 967–972.

https://doi.org/10.1042/BST0320967

Published: 26 October 2004

.... The basic paradigm emerging is that a number of groups of genes are expressed in successive waves at different cell cycle times. Transcription of a particular group is controlled by a common DNA motif present in each gene's promoter, bound by a transcription factor complex. Each motif and transcription...

View articletitled, Cell cycle-regulated transcription in fission yeast

Articles

The anaphase-promoting complex (APC): the sum of its parts?

L.A. Passmore

Biochem Soc Trans (2004) 32 (5): 724–727.

https://doi.org/10.1042/BST0320724

Published: 26 October 2004

...L.A. Passmore The APC (anaphase-promoting complex) is a multisubunit E3 ubiquitin ligase that targets cell-cycle-related proteins for degradation by the 26 S proteasome. The APC contains at least 13 subunits and is regulated by the binding of co-activator proteins and by phosphorylation...

View articletitled, The anaphase-promoting complex (APC): the sum of its parts?

Articles

Phosphoinositide 3-kinase and Forkhead, a switch for cell division

L. Martínez-Gac, B. Álvarez, Z. García, M. Marqués, M. Arrizabalaga, A.C. Carrera

Biochem Soc Trans (2004) 32 (2): 360–361.

https://doi.org/10.1042/bst0320360

Published: 01 April 2004

...L. Martínez-Gac; B. Álvarez; Z. García; M. Marqués; M. Arrizabalaga; A.C. Carrera Cell cycle progression is a tightly controlled process. To initiate cell division, mitogens trigger a number of early signals that promote the G 0 –G 1 transition by inducing cell growth and the activation of G 1...

View articletitled, Phosphoinositide 3-kinase and Forkhead, a switch for cell division

Update search

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only