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Keywords: cell death
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Articles
Biochem Soc Trans (2024) 52 (4): 1703–1713.
Published: 02 August 2024
...Emily T. Chan; Cömert Kural Evading programmed cell death (PCD) is a hallmark of cancer that allows tumor cells to survive and proliferate unchecked. Endocytosis, the process by which cells internalize extracellular materials, has emerged as a key regulator of cell death pathways in cancer. Many...
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Biochem Soc Trans (2024) 52 (2): 693–706.
Published: 17 April 2024
...Magali Walravens; Ine Koeken; Tom Vanden Berghe Pathological breakdown of membrane lipids through excessive lipid peroxidation (LPO) was first described in the mid-20th century and is now recognized as a form of regulated cell death, dubbed ferroptosis. Accumulating evidence unveils how metabolic...
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Biochem Soc Trans (2023) 51 (3): 1377–1385.
Published: 30 May 2023
...Yeping Wu; Ye-Wheen Lim; Robert G. Parton Oxidative stress is a feature of many disease conditions. Oxidative stress can activate a number of cellular pathways leading to cell death, including a distinct iron-dependent pathway involving lipid peroxidation, termed ferroptosis, but cells have evolved...
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Biochem Soc Trans (2023) 51 (2): 759–769.
Published: 06 April 2023
...Loic Fort In our human society, would you not want to know if your neighbor suddenly passed away? Tissues and cells are not that different. Cell death is an inevitable part of tissue homeostasis and comes in different flavors that can either be a consequence of an injury or a regulated phenomenon...
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Biochem Soc Trans (2023) 51 (1): 457–472.
Published: 23 February 2023
...Rosalie Heilig; Jordan Lee; Stephen W.G. Tait Cytosolic DNA is recognized by the innate immune system as a potential threat. During apoptotic cell death, mitochondrial DNA (mtDNA) release activates the DNA sensor cyclic GMP–AMP synthase (cGAS) to promote a pro-inflammatory type I interferon...
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Biochem Soc Trans (2023) 51 (1): 21–29.
Published: 11 January 2023
... proteins. However, the expression of CD95L has been reported to induce cell death in contexts in which this pathway is unlikely to be activated, such as in cell autonomous activation induced cell death (AICD) and in CD95-resistant cancer cell lines. Recent data suggests that the CD95L mRNA exerts toxicity...
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Biochem Soc Trans (2022) 50 (4): 1119–1128.
Published: 28 July 2022
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . BCL-2 proteins cancer cell death chemotherapy The BCL-2 family proteins are key-regulators of the intrinsic apoptotic pathway. Members of this family contain BCL-2 homology (BH...
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Biochem Soc Trans (2022) 50 (3): 1205–1213.
Published: 27 June 2022
... in cell survival and mammalian embryonic development. In recent years, GPX4 has been associated with a cell death modality dubbed ferroptosis. The framing of this molecular pathway of cell death was essential for understanding the conditions that determine GPX4 dependency and ultimately to the process...
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Biochem Soc Trans (2022) 50 (2): 813–824.
Published: 28 March 2022
...Elias S. Weiler; Tamas G. Szabo; Irmina Garcia-Carpio; Andreas Villunger The death fold domain-containing protein PIDD1 has recently attracted renewed attention as a regulator of the orphan cell death-related protease, Caspase-2. Caspase-2 can activate p53 to promote cell cycle arrest in response...
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Biochem Soc Trans (2020) 48 (5): 2253–2259.
Published: 14 October 2020
...Helene Nehring; Svenja Meierjohann; Jose Pedro Friedmann Angeli Lipid peroxidation has been associated with a wide array of (patho)physiological conditions. Remarkably, in the last few years, a novel cell death modality termed ferroptosis was recognized as a process initiated by iron-dependent...
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Biochem Soc Trans (2018) 46 (2): 207–215.
Published: 22 February 2018
... lysosomal contents, which include proteolytic enzymes of the cathepsin family. This, in turn, activates several intracellular cascades that promote a type of regulated cell death, called lysosome-dependent cell death (LDCD). LDCD can be inhibited by pharmacological or genetic blockade of cathepsin activity...
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Biochem Soc Trans (2017) 45 (1): 163–172.
Published: 15 February 2017
... with increased disease risk [ 5 ]. It is anticipated that investigating these familial and risk genes will provide important insight into the molecular mechanisms and pathways that precipitate neurodegeneration in idiopathic PD. cell death enzyme activity leucine-rich repeat kinase neurodegeneration...
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Biochem Soc Trans (2012) 40 (5): 1070–1073.
Published: 19 September 2012
... in and affect the function of vesicular structures in cells. autophagy cell death inclusion body leucine-rich repeat kinase 2 (LRRK2) neurite Parkinson's disease The identification of dominant mutations in LRRK2 (leucine-rich repeat kinase 2) by two groups in 2004 [ 1 , 2 ], together...
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Biochem Soc Trans (2011) 39 (5): 1520–1526.
Published: 21 September 2011
...Ralf J. Braun; Benedikt Westermann Mitochondria play crucial roles in programmed cell death and aging. Different stimuli activate distinct mitochondrion-dependent cell death pathways, and aging is associated with a progressive increase in mitochondrial damage, culminating in oxidative stress...
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Biochem Soc Trans (2007) 35 (5): 1119–1121.
Published: 25 October 2007
... combined with NO results in cell death via respiratory inhibition, and PHOX activation combined with iNOS expression results in death via peroxynitrite production. However, the above mechanism requires relatively high levels of NO or iNOS expression, and iNOS can be expressed in vitro [ 22...
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Biochem Soc Trans (2006) 34 (5): 953–956.
Published: 25 October 2006
... peroxynitrite reacts with CO 2 to give NO 2 and the carbonate radical (CO 3 •− ), which is another strong oxidant. See Scheme 1 for a summary of these interactions. cell death mitochondrion peroxynitrite reactive nitrogen species reactive oxygen species H 2 O 2 has no obvious acute...
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Biochem Soc Trans (2004) 32 (3): 493–495.
Published: 01 June 2004
...M. Degli Esposti The role of mitochondria in cell death has been increasingly appreciated in the last few years and is now well established in a variety of cellular systems. At present we know that the involvement of mitochondria is regulated by proteins of the Bcl-2 (B-cell lymphocytic-leukaemia...
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Biochem Soc Trans (2001) 29 (6): 696–702.
Published: 01 November 2001
... earlier in the cascade. Many cellular stresses provoke apoptosis by damaging mitochondria which results in the release of factors [such as cytochrome c and SMAC (second mitochondrial-derived activator of caspase)/Diablo] that trigger caspase activation and cell death. Here, we discuss the hierarchical...
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Biochem Soc Trans (2001) 29 (6): 684–688.
Published: 01 November 2001
... or apoptotic cell death. Cell death induced through the p53 pathway is executed by the caspase proteinases, which, by cleaving their substrates, lead to the characteristic apoptotic phenotype. Caspase activation by p53 occurs through the release of apoptogenic factors from the mitochondria, including...
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Biochem Soc Trans (2000) 28 (4): 452–455.
Published: 01 August 2000
...D. E. Brenneman; C. Y. Spong; I. Gozes In studying the mediators of VIP neurotrophism in the central nervous system, two glial proteins have been discovered. Both of these proteins contain short peptides that exhibit femtomolar potency in preventing neuronal cell death from a wide variety...