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1-9 of 9
Keywords: cell differentiation
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Articles
Modulating cell differentiation in cancer models
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1803–1816.
Published: 26 August 2021
... of differentiation-based approaches. Correspondence: Virginie Sottile ( [email protected] ) 14 6 2021 6 8 2021 10 8 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cancer cell cell differentiation stem cell therapy...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 805–814.
Published: 30 April 2021
... with a host of haematopoietic neoplasms [ 4 ] as well as impaired immune system responses [ 5 ]. Figure 1. Haematopoiesis involves the epigenetic silencing of alternate fate genes, reducing multipotency and the self-renewal capacity as cells differentiate. Haematopoietic stem cells (HSC) differentiate...
Articles
Shaping axial identity during human pluripotent stem cell differentiation to neural crest cells
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 499–511.
Published: 11 January 2021
... the in vitro generation of human NC cells which are representative of various A–P positions. Here, we explore recent advances in methodologies of in vitro NC specification and axis patterning using hPSCs. anterior–posterior patterning cell differentiation homeobox genes human pluripotent stem cells...
Articles
An integrated transcriptional switch at the β-selection checkpoint determines T cell survival, development and leukaemogenesis
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (4): 1077–1089.
Published: 27 June 2019
... 5 6 2019 6 6 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cell differentiation developmental biology T cells A key attribute of T cell immunity is the expression of a distinct T cell receptor (TCR) on each T...
Articles
TET enzymes, DNA demethylation and pluripotency
Available to PurchaseIn Collection
Embryonic development
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (3): 875–885.
Published: 17 June 2019
... acid (RA) increase expression of Tet2 and Tet3 through binding to conserved RA-responsive elements [ 24 ]. cell differentiation epigenetics epigenomics methylation model organisms pluripotency Genome-wide profiling of 5hmC and TET1 protein binding sites have revealed enrichment...
Articles
Cell cycle-dependent phosphorylation and regulation of cellular differentiation
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1083–1091.
Published: 21 September 2018
... by directed differentiation of stem cells is emerging as a powerful tool in disease modelling and with exciting potential in regenerative medicine [ 6 ]. Conversely, inappropriate replication is a fundamental hallmark of cancer [ 7 ]. cell cycle cell differentiation phosphorylation/dephosphorylation...
Articles
Function and regulation of the mammalian Musashi mRNA translational regulator
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 528–530.
Published: 21 May 2008
... Society 2008 cell differentiation cell proliferation mRNA translation Musashi protein neural stem cell Xenopus Musashi exerts translational repression of target mRNAs via a 5′-cap-dependent mechanism in neural stem cells, but paradoxically exerts target mRNA translational activation...
Articles
Differential role of TRP channels in prostate cancer
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 133–135.
Published: 22 January 2007
...N. Prevarskaya; M. Flourakis; G. Bidaux; S. Thebault; R. Skryma A major clinical problem with PC (prostate cancer) is the cell's ability to survive and proliferate upon androgen withdrawal. Indeed, deregulated cell differentiation and proliferation, together with the suppression of apoptosis...
Articles
Transcription factories: structures conserved during differentiation and evolution
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1133–1137.
Published: 25 October 2006
... remain roughly constant as cells differentiate, despite large changes in the numbers of active polymerases and nucleoplasmic volumes. cell differentiation chromatin loop genome organization RNA polymerase transcription factory Molecules are concentrated within cells into distinct cellular...