... into the order in which they occur and to determine the function of the various cellular machinery employed (see Figure 1 ). Figure 1. Illustration of the stages of macropinocytosis as described in the text. actin dynamics cell migration endocytosis macropinocytosis trafficking...

...Florian Fäßler; Manjunath G. Javoor; Florian KM Schur The actin cytoskeleton plays a key role in cell migration and cellular morphodynamics in most eukaryotes. The ability of the actin cytoskeleton to assemble and disassemble in a spatiotemporally controlled manner allows it to form higher-order...

... on mitosis and cell migration, as well as discuss potential productive future research avenues that might reveal novel insights into the overall dynamics of the pathway. Correspondence: Carsten Gram Hansen ( Carsten.G.Hansen@ed.ac.uk ) * Lead Contact. 30 3 2021 22 6 2021 23 6...

...Björn Stinner; Till Bretschneider Directed cell migration poses a rich set of theoretical challenges. Broadly, these are concerned with (1) how cells sense external signal gradients and adapt; (2) how actin polymerisation is localised to drive the leading cell edge and Myosin-II molecular motors...

...Valentina Gifford; Yoshifumi Itoh Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier of cellular microenvironment and promotes cell migration and invasion of a wide variety...

... work into the function of APPL1 in cell migration and adhesion. Correspondence: Donna J. Webb ( donna.webb@vanderbilt.edu ) 15 12 2016 17 3 2017 22 3 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 cell adhesion...

... remodeling of the stromal extracellular matrix (ECM) by CAFs are important contributors to tumor cell migration and invasion, which are critical for cancer progression from a primary tumor to metastatic disease. In this review, we discuss key paracrine signaling pathways between CAFs and cancer cells...

...Joseph H.R. Hetmanski; Jean-Marc Schwartz; Patrick T. Caswell Metastasis, initially driven by cells migrating and invading through the local environment, leads to most cancer-associated deaths. Cells can use a variety of modes to move in vitro , all of which depend on Rho GTPases at some level...

... summarize the current knowledge on kinesin functions in cell migration. 1 To whom correspondence should be addressed (email anne@mechanochemistry.org ) . 16 10 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 cell adhesion cell migration force generation...

... that macropinocytosis and cell migration are negatively correlated. Heavy drinkers move only slowly and vice versa, fast cells do not take big gulps. Both processes are balanced by the lipid phosphatidylinositol 3,4,5-trisphosphate (PIP 3 ). Elevated PIP 3 signalling causes a shift towards macropinocytosis and inhibits...

... resolution and cryo-ET for preserving overall 3D morphology was crucial for obtaining a complete structure–function analysis of actin-driven propulsion. 1 email vic.small@imba.oeaw.ac.at 9 7 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 actin cell...

... compilation © 2014 Biochemical Society 2014 actin cell migration cell plasticity collagen melanoma Actin-based cytoskeletal polarization and dynamics are indispensable for cell positioning in tissues and organs during morphogenesis, immune defence and regeneration, and, in its deregulated...

... as chimaeric forms of NM II (II-A head and II-B tail and vice versa) to substitute for NM II-A in cell–cell adhesions in II-A-ablated mice. However, we also show that certain functions, such as neuronal cell migration in the developing brain and vascularization of the mouse embryo and placenta, specifically...

... and differentiation, whereas Myo9b has been shown to play an important role in the regulation of macrophage shape and motility. 1 To whom correspondence should be addressed (email baehler@uni-muenster.de ). How might regulation of Rho signalling by Myo9b contribute to directed cell migration...

... on the role of different trafficking pathways in epithelial cell migration, including clathrin-mediated endocytosis, caveolar endocytosis, exocytosis of biosynthetic cargo, ‘short-loop’ and ‘long-loop’ endosomal recycling. The precise function of caveolar endocytosis in cell migration has been disputed...

... by chemokines in T-lymphocytes is the activation of several members of the PI3K (phosphoinositide 3-kinase) family. In many cell systems, PI3Ks are known to contribute to several aspects of the migratory machinery, although their role in T-cell migration has been unclear and will be considered in the present...

.... Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN...

... largely remain unknown. BPGAP1 is a novel RhoGAP that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 and Cdc42GAP homology domains serving as a homophilic/heterophilic interaction device, an enzymic RhoGAP domain that inactivates RhoA and a proline-rich region...

...: a Biochemical Society Focused Meeting held at Chancellors Conference Centre, University of Manchester, 1–3 December 2003 3 December 2003 © 2004 Biochemical Society 2004 actin cytoskeleton cell migration fluorescence lifetime imaging microscopy (FLIM) fluorescence resonance energy...

..., interleukin-6 and interferon-γ, at the level of mRNA stability and translation. In the case of TNF-α, this regulation depends on the AU-rich element in TNF-α mRNA. In addition to cytokine expression, MK2 is also essential for cell migration in vitro. Although the role of MK2 in cytokine expression depends...

..., extracellular matrix EIIIA, exon IIIA EIIIB, exon IIIB, MMP, matrix metalloproteinase PDGF, platelet-derived growth factor VSMC, vascular smooth muscle cells cell migration 3/4 collagen fragment exon IIIA exon IIIB Biochemical Society Transactions (2002) Volume 30, part 2 teinases and asking...