...) . bookmarking centromere gene expression mitosis RNA Pol II transcription More than 60 years ago, Prescott and Bender [ 1 ] first reported a drastic silence of transcription during mitosis by using nascent RNA labeling in HeLa cells ( Figure 1A,B ). The underlying mechanisms remained unknown until...

... 27 3 2020 30 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 centromere embryo epigenetics histone chaperone nucleolus ribosomes The nucleolus is the most prominent nuclear organelle in almost all cells...

...Hiroshi Sato; Shigeaki Saitoh The kinetochore, which forms on a specific chromosomal locus called the centromere, mediates interactions between the chromosome and the spindle during mitosis and meiosis. Abnormal chromosome rearrangements and/or neocentromere formation can cause the presence...

...Susan L. Forsburg Replication stress is a significant contributor to genome instability. Recent studies suggest that the centromere is particularly susceptible to replication stress and prone to rearrangements and genome damage, as well as chromosome loss. This effect is enhanced by loss...

...Fekret Osman; Matthew C. Whitby Centromere proteins CENP-S and CENP-X are members of the constitutive centromere-associated network, which is a conserved group of proteins that are needed for the assembly and function of kinetochores at centromeres. Intriguingly CENP-S and CENP-X have alter egos...

... stability. The functional competence of STB requires the plasmid-coded partitioning proteins Rep1 and Rep2 as well as host-coded proteins. Host factors that associate with STB in a Rep1- and Rep2-dependent manner also interact with centromeres, and play important roles in chromosome segregation...

... in both pathways. In this review we focus on a poorly understood but important aspect of mitotic control: what prevents the mitotic checkpoint from springing into action when sister centromeres are split and tension is suddenly lost at anaphase onset? Recent work has shown that disjunction of sister...

...Bernardo Orr; Olga Afonso; Tália Feijão; Claudio E. Sunkel The kinetochore is a complex molecular machine that serves as the interface between sister chromatids and the mitotic spindle. The kinetochore assembles at a particular chromosomal locus, the centromere, which is essential to maintain...

... of chromosome territories [ 4 ]. Furthermore, overall nuclear architecture in the mammalian sperm cell is orderly arranged ( Figure 1 A). All chromosomes are joined through centromeres that are combined into internally localized chromocentre [ 5 – 8 ], while chromosome ends are exposed to the nuclear...

...R. Waldron; T. Moore The mouse jerky gene and its human orthologue, JRK / JH8 , encode a putative DNA-binding protein with homology to the CENP-B (centromere-binding protein B). Disruption of the mouse jerky gene by transgene insertion causes generalized recurrent seizures reminiscent of human...