... of cellular stress response that buffer excess free fats and protect cells from lipotoxicity. Ceramide is a bioactive lipid that accumulates in metabolic tissues during fat oversupply. Emerging evidence suggests that sphingolipids and sphingolipid-metabolizing enzymes are found in the LDs and affect LD...

[email protected] ). 26 11 2015 © 2016 Authors; published by Portland Press Limited 2016 ceramide cholesterol contact site endoplasmic reticulum phosphatidylserine phosphoinositide The membrane compartments of eukaryotic cells communicate via tubulovesicular carriers that bud from...

...Félix M. Goñi; Jesús Sot; Alicia Alonso Some of the simplest sphingolipids, namely sphingosine, ceramide and their phosphorylated compounds [sphingosine 1-phosphate (Sph-1-P) and ceramide 1-phosphate (Cer-1-P)], are potent metabolic regulators. Each of these lipids modifies in marked and specific...

...Aimee L. Edinger Ceramide induces differentiation, proliferative arrest, senescence and death in mammalian cells. The mechanism by which ceramide produces these outcomes has proved difficult to define. Building on observations that ceramide stimulates autophagy, we have identified a novel mechanism...

... (death-inducing signalling complex) was detected in neutrophils, but blocking antibodies to death receptors did not inhibit apoptosis, suggesting a novel mechanism for caspase 8 activation. Death receptor clustering in ceramide-rich lipid rafts is thought to be an early event in their signalling, so we...

... sphingomyelinase activity, sphingomyelin and ceramide contents, and the level of lipid peroxide products (conjugated dienes), in the cerebral cortex, hippocampus and cerebellum of rats within 3 h and 7 days of intracerebral injection of A-β and TNF-α. A single injection of A-β and TNF-α has been shown to increase...

...W. J. van Blitterswijk; A. H. van der Luit; W. Caan; M. Verheij; J. Borst Sphingolipids and their metabolites are implicated in signal transduction, but the mechanisms are still poorly understood. In particular, the presumed function of ceramide as a second messenger remains controversial. Here, we...

... Society 2001 ceramide diacylglycerol endothelial differentiation gene receptors lysophosphatidate phosphatidate sphingosine 1-phosphate ARF, ADP ribosylation factor CIP, ceramide 1-phosphate DAG, diacylglycerol EDG, endothelial differentiation gene ERK, extracellular-signal-regulated...

... glucosylation was sensitive to proteolytic enzymes, ceramide glucosylation was not. These results are consistent with our model in which steryl glucoside is synthesized on the cytosolic side of the membrane and then translocated across the membrane where it donates glucose to ceramide. 1 To whom...