... by the participation of University of Liverpool in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. Blood–brain barrier cerebral ischaemia flow disturbances inflammation neurological disorders SARS-CoV-2...

... Correspondence may be addressed to either of the authors (email [email protected] or [email protected] ). 16 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 brain-derived neurotrophic factor (BDNF) cerebral ischaemia γ-aminobutyric acid (GABA) long...

...S. Murphy; C.L. Gibson Cerebral ischaemia results in the activation of three isoforms of NOS (nitric oxide synthase) that contribute to the development of and recovery from stroke pathology. This review discusses, in particular, the role of the transcriptionally activated NOS-2 (inducible NOS...

...T. Yamashita; K. Deguchi; K. Sawamoto; H. Okano; T. Kamiya; K. Abe Possible strategies for treating ischaemic stroke include: (i) neuroprotection (preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischaemia), and (ii) neurosupplementation (the repair of broken...

... that regulates transcription of genes involved in apoptosis and inflammation. In a mouse model of focal cerebral ischaemia, there is an induction of the cytokine TWEAK (tumour necrosis factor-like weak inducer of apoptosis) and its membrane receptor Fn14. TWEAK promotes neuronal cell death and activates...

...C.-Z. Lu; B.-G. Xiao In several experimental studies of cerebral ischaemia, G-CSF (granulocyte colony-stimulating factor) exerted neuroprotective effects through different mechanisms, including mobilization of haemopoietic stem cells, anti-apoptosis, neuronal differentiation, angiogenesis and anti...

... as a neuroprotective agent in cerebral ischaemia. Fibrates and other non-fibrate PPARα activators as well as thiazolidinediones and other non-thiazolidinedione PPARγ agonists have been demonstrated to induce both preventive and acute neuroprotection. This neuroprotective effect involves both cerebral and vascular...

... J.A. Hurn P.D. Stroke 1999 30 1665 1670 34 Sudo S. Wen T.C. Desaki J. Matsuda S. Tanaka J. Arai T. Maeda N. Sakanaka M. Neurosci. Res. 1997 29 345 354 13 7 2006 © 2006 The Biochemical Society 2006 cerebral ischaemia...

... of the infarct as well as in larger vessels. blood–brain barrier brain injury cerebral ischaemia endothelial cell oxidative stress reperfusion Ischaemic stroke results from the abrupt occlusion of cerebral blood vessels. Early restoration of cerebral blood flow, either by pharmacological...