... as replicative senescence. During senescence, the actions of both these apical kinases and telomere-binding proteins allow checkpoint activation while bulk DNA repair activities at telomeres are still inhibited. Checkpoint-mediated cell cycle arrest also prevents further telomere erosion and deprotection...

...Vasundhara M. Navadgi-Patil; Peter M. Burgers Mec1 [ATR (ataxia telangiectasia mutated- and Rad3-related) in humans] is the principle kinase responsible for checkpoint activation in response to replication stress and DNA damage in Saccharomyces cerevisiae . The heterotrimeric checkpoint clamp, 9-1...

... correspondence should be addressed (email [email protected] ). 31 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 budding yeast checkpoint DNA damage proliferating-cell nuclear antigen (PCNA) replication ubiquitin-processing protease (UBP) A variety of lesions...

...Ronan Broderick; Heinz-Peter Nasheuer The Cdc (cell division cycle) 45 protein has a central role in the regulation of the initiation and elongation stages of eukaryotic chromosomal DNA replication. In addition, it is the main target for a Chk1 (checkpoint kinase 1)-dependent Cdc25/CDK2 (cyclin...

... checkpoint control, chromatin remodelling and ubiquitination. In addition, substantial data now exist to suggest a role for BRCA1 in transcriptional regulation; BRCA1 has been shown to interact with the Pol II holoenzyme complex and to interact with multiple transcription factors, such as p53 and c-Myc. We...

... transport receptors, thereby promoting organization of mitotic spindles with respect to chromosomes. In addition to this role of soluble Ran-GTP, Ran has two important but less understood roles at mitotic kinetochores. Namely, it is essential for regulation of the spindle assembly checkpoint...

... in offspring. Co-ordination between chromosomal exchange and meiotic cell-cycle progression is achieved via a surveillance mechanism commonly referred to as the recombination checkpoint. Both components of the mitotic DNA damage checkpoint as well as meiosis-specific functions contribute to this highly...

... model of the eukaryotic cell-division cycle. With this comprehensive model, we also discuss the mechanisms by which different checkpoint pathways stabilize different cell-cycle states and inhibit the transitions that drive cell-cycle progression. 1 To whom correspondence should be addressed...

... in response to physiological signals, revealing their role in developmental checkpoints such as differentiation commitment. 1 e-mail [email protected] 26 6 2001 © 2001 Biochemical Society 2001 apoptosis ataxia telangiectasia mutated checkpoint DNA damage repair p53 signal...