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Keyword: chemokine
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Articles
Biochem Soc Trans (2013) 41 (1): 231-236.
Published: 29 January 2013
...Cinzia Cancellieri; Alessandro Vacchini; Massimo Locati; Raffaella Bonecchi; Elena M. Borroni ACRs (atypical chemokine receptors) were initially referred to as ‘silent’ receptors on the basis of a lack of signalling and functional activities that are typically observed with conventional chemokine...
Articles
Biochem Soc Trans (2011) 39 (6): 1560-1564.
Published: 21 November 2011
... correspondence should be addressed (email a.bikfalvi@angio.u-bordeaux1.fr ). 12 9 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis chemokine combinatorial therapy resistance to anti-angiogenesis therapy stress response vascular endothelial growth...
Articles
Biochem Soc Trans (2011) 39 (6): 1649-1653.
Published: 21 November 2011
... destabilization of this plaque. Cellular and molecular approaches are studied by in vitro assay of activated endothelial cells and in in vivo models of neovascularization. Chemokines are a large family of small secreted proteins that have been shown to play a critical role in the regulation of angiogenesis during...
Articles
Biochem Soc Trans (2007) 35 (5): 1163-1165.
Published: 25 October 2007
... 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 atherosclerosis chemokine interleukin neutrophil stroke systemic inflammation Most stroke patients present with co-morbidities, such as atherosclerosis, hypertension, diabetes or infection, all of...
Articles
Biochem Soc Trans (2007) 35 (5): 1109-1113.
Published: 25 October 2007
...J.S. Oak; M.P. Matheu; I. Parker; M.D. Cahalan; D.A. Fruman The PI3K (phosphoinositide 3-kinase) family of lipid kinases regulate cell motility in diverse organisms and cell types. In mammals, the main PI3K enzyme activated by chemokine receptor signalling is the class IB isoform, p110γ. Studies of...
Articles
Biochem Soc Trans (2007) 35 (5): 1375-1376.
Published: 25 October 2007
...-associated adenocarcinoma in IL-10 −/− mice. TLR4-dependent chemokine induction may play a part in modulating the development of colitis-associated neoplasia through altered leucocyte recruitment. 1 To whom correspondence should be addressed (email dmmccaff@ucalgary.ca ). 3 7 2007 © The...
Articles
Biochem Soc Trans (2007) 35 (2): 193-198.
Published: 20 March 2007
...L. Smith; A. Webb; S.G. Ward The co-ordinated and directional trafficking of T-lymphocytes in lymphoid and peripheral tissues is an important process in lymphoid development, immunosurveillance and immune responses. Members of the chemokine superfamily play a key role in providing navigational cues...
Articles
Biochem Soc Trans (2007) 35 (2): 270-272.
Published: 20 March 2007
... t.lawrence@imperial.ac.uk ). 1 11 2006 © 2007 The Biochemical Society 2007 adaptive immunity chemokine dendritic cell (DC) inflammation inhibitor of nuclear factor κB kinase (IKK) nuclear factor κB (NF-κB) The inflammatory response requires co-ordinated activation of various...
Articles
Biochem Soc Trans (2006) 34 (6): 997-1001.
Published: 25 October 2006
...P. Proost; S. Struyf; J. Van Damme Chemokines, adhesion molecules, cytokines and proteases regulate the extravasation of leucocytes during acute and chronic inflammation and leucocyte homing. Chemokines are produced after transcriptional activation by inflammatory mediators such as cytokines or...
Articles
Biochem Soc Trans (2006) 34 (6): 1005-1008.
Published: 25 October 2006
...M. Pruenster; A. Rot Chemokines play a key role in directing and driving leucocyte trafficking. The efficient regulation of leucocyte recruitment by chemokines requires their appropriate localization in functional micro-anatomical domains, as well as setting limits to their effects in space and...
Articles
Biochem Soc Trans (2006) 34 (3): 422-426.
Published: 22 May 2006
...A.E.I. Proudfoot Chemokines exert their biological activity through high-affinity interactions with cell-surface receptors, thereby activating specific signalling pathways, and a second low-affinity interaction with proteoglycans. Proteoglycans consist of a protein core, to which GAG...
Articles
Biochem Soc Trans (2004) 32 (5): 750-752.
Published: 26 October 2004
... whom correspondence should be addressed (email amaclean@tulane.edu ). 19 7 2004 © 2004 The Biochemical Society 2004 blood–brain barrier chemokine chemotaxis encephalitis neuroimmunology simian immunodeficiency virus (SIV) Neurological disease is a common complication of...
Articles
Biochem Soc Trans (2004) 32 (4): 629-632.
Published: 01 August 2004
... kDa fragment (amino acids 495–609). Immunological functions of these three different domains in stimulating monocytes and dendritic cells have not been fully defined. However, the C-terminal portion (amino acids 359–610) stimulates the production of CC chemokines, IL-12 (interleukin-12), TNFα(tumour...
Articles
Biochem Soc Trans (2004) 32 (2): 366-377.
Published: 01 April 2004
...Z. Johnson; C.A. Power; C. Weiss; F. Rintelen; H. Ji; T. Ruckle; M. Camps; T.N.C. Wells; M.K. Schwarz; A.E.I. Proudfoot; C. Rommel Chemokines are small chemoattractant cytokines that control a wide variety of biological and pathological processes, ranging from immunosurveillance to inflammation...