... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . BCL-2 proteins cancer cell death chemotherapy The BCL-2 family proteins are key-regulators of the intrinsic apoptotic pathway. Members of this family contain BCL-2 homology (BH) regions and can be broadly separated...

... allosteric inhibitor cancer chemotherapy dimerization monobody RAS GTPase RAS has been at the forefront of cancer research due to its prominence in the onset and progression of human cancers. Somatic mutations in RAS are a hallmark of many cancers with ∼19% of cancer patients harboring RAS...

... chemotherapy combination therapy immunotherapy photodynamic therapy radiotherapy tyrosine kinase inhibitors Conventional chemotherapeutic agents are usually administered at their maximum tolerated dose (MTD) and exert their anti-tumour effects by killing cells that divide rapidly. In general...

... [ 12 ]. An additional benefit of cancer metabolism is high levels of NADPH for redox homoeostasis [ 13 ]. apoptosis chemotherapy lymphoma metabolism mitochondrion redox homoeostasis Figure 1 Mitochondria are central to redox homoeostasis, metabolism and apoptosis resistance...

... with increased sensitivity to DNA damage-based chemotherapy and resistance to spindle poisons. 1 To whom correspondence should be addressed (email d.harkin@queens-belfast.ac.uk ). 18 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 breast-cancer susceptibility...

... in tumours could lead to improved cancer diagnosis, choice of therapy and, ultimately, development of new drugs. 1 email n.d.perkins@dundee.ac.uk 12 6 2004 © 2004 The Biochemical Society 2004 ADP-ribosylation factor (ARF) chemotherapy DNA damage p53 RelA UV light ARF...

..., such as cell-cycle control, apoptosis signalling and DNA repair can frequently become epigenetically silenced and methylated in tumours. This may lead to differences in intrinsic sensitivity of tumours to chemotherapy, depending on the specific function of the gene inactivated. Furthermore, chemotherapy itself...

... total NF-κB inhibition. 1 To whom correspondence should be addressed (email k.j.campbell@dundee.ac.uk ). 5 7 2004 © 2004 The Biochemical Society 2004 chemotherapy nuclear factor κB (NF-κB) post-translational modification RelA transcription UV light NF-κB...

... 2002 22 January 2003 cancer chemotherapy inhibitor putrescine spermidine spermine Abbreviations used: DFMO, α-difluoromethylornithine; ODC, ornithine decarboxylase; ADOMETDC, S -adenosylmethionine decarboxylase; SSAT, spermidine/spermine N 1 -acetyltransferase; BENSpm...