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Keywords: chloromethane
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13 C- and 1 H-NMR studies of oxyanion and tetrahedral intermediate stabilization by the serine proteinases: optimizing inhibitor warhead specificity and potency by studying the inhibition of the serine proteinases by peptide-derived chloromethane and glyoxal inhibitors

J.P.G. Malthouse
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 566–570.
https://doi.org/10.1042/BST0350566
Published: 22 May 2007
... and chymotrypsin using substrate-derived chloromethane inhibitors. One of the limitations of these inhibitors is that they irreversibly alkylate the active-site histidine residue which results in the oxyanion not being in the optimal position in the oxyanion hole. Substrate-derived glyoxal inhibitors...
View article titled, 13 C- and 1 H-NMR studies of oxyanion and tetrahedral intermediate stabilization by the serine proteinases: optimizing inhibitor warhead specificity and potency by studying the inhibition of the serine proteinases by peptide-derived <span class="search-highlight">chloromethane</span> and glyoxal inhibitors
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