..., conversely, the mono-allelic gene expression also influences genome architecture. chromatin architecture chromatin loop CTCF genomic imprinting topologically associating domain During interphase, the mammalian genome is configurated into compartments and ‘topologically associating domains...

...-dimensional (3D) architecture [ 6 ]. More recently, it has been shown that chromosome organization across individual cells is significantly heterogeneous [ 7 ]. Still, what is the exact nature of this connection –– whether, for instance, chromatin architecture plays an instructive role in regulating gene...